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Oklahoma State Firefighters Museum
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Serial/Series Title
Degree Department
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Decade
Month
Anti-S2 Peptides and Antibodies Binding Effect on Myosin S2 and Anti-S2 Peptide's Ability to Reach the Cardiomyocytes in vivo and Interfere in Muscle Contraction
The anti-S2 peptides, the stabilizer and destabilizer, were designed to target myosin sub-fragment 2 (S2) in muscle. When the peptides are coupled to a heart-targeting molecule, they can reach the cardiomyocytes and interfere with cardiac muscle contraction. Monoclonal antibodies, MF20 and MF30, are also known to interact with light meromyosin and S2 respectively. The MF30 antibody compared to anti-S2 peptides and the MF20 antibody is used as a control to test the central hypothesis that: Both the anti-S2 peptides and antibodies bind to myosin S2 with high affinity, compete with MyBPC, and possibly interact with titin, in which case the anti-S2 peptides have further impact on myosin helicity and reach the heart with the aid of tannic acid to modulate cardiomyocytes' contraction in live mice. In this research, the effects of anti-S2 peptides and antibodies on myosin S2 were studied at the molecular and tissue levels. The anti-myosin binding mechanism to whole myosin was determined based on total internal reflectance fluorescence spectroscopy (TIRFS), and a modified cuvette was utilized to accommodate this experiment. The binding graphs indicated the cooperative binding of the peptides and antibodies with high affinity to myosin. Anti-myosin peptides and antibodies competition with Myosin Binding Protein C …
Date:
July 2023
Creator:
Quedan, Duaa Mohamad Alhaj Mahmoud
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
An Assessment and Intervention Model for Establishing Observational Learning During Tact Trials
Observational learning (OL) allows an individual to acquire novel responses by observing others' behavior and the corresponding consequences. The complexity of skills involved with OL may vary with the learning context. A learner may observe modeled responses to both trained (known) and untrained (unknown) stimuli or they may observe both reinforced (correct) and nonreinforced (incorrect) responses. The purpose of this study was to develop assessment and training procedures for OL component skills when the learner observes a combination of learning contexts: reinforced and nonreinforced responses to both trained and untrained stimuli. Two children with autism, Tom and David, participated. We assessed the following component skills in the context of tact trials: (1) Discriminating trained and untrained stimuli, (2) attending to the modeled performance, (3) discriminating consequences, and (4) conditionally responding based upon a name call. Next, we trained the component skill(s) for which the learner's performance did not meet criterion and then reassessed for OL. For both participants, immediate increases in OL were observed; however, modifications to the post-assessment (differential observing response for consequences and/or differential reinforcement) were required to produce (Tom) or maintain (David) criterion levels of responding. Interpretations of these outcomes, as well as limitations and directions for …
Date:
July 2023
Creator:
Sansing, Elizabeth McKay
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
An Assessment of Digital Stimulus Prompts to Teach Conditional Discriminations to Children with Autism
Effective and efficient skill-acquisition procedures must be identified to support individualized behavioral programming for children with autism spectrum disorder (ASD). To do this, practitioners and researchers may use assessment-based instruction. Prompts are a common teaching strategy to promote skill acquisition. The purpose of this applied study was to use assessment-based instruction to evaluate the efficacy and efficiency of within- and extra-stimulus prompts to teach conditional discriminations to two children with ASD. We identified stimulus prompts using a survey of popular children's games and conducted a tablet-based instruction readiness assessment. Stimulus prompts involved motion (within-stimulus) and pointing (extra-stimulus) to evoke correct responses in the presence of a discriminative stimulus. We used an adapted alternating treatments design with a no-treatment control condition to evaluate the effects of both prompt types across multiple sets of stimuli. Both stimulus prompt types were efficacious in facilitating skill acquisition for two of three participants. Little difference was observed in the time to mastery with either prompt. Neither stimulus prompt was efficacious for the third participant. Assessment results will be used to inform clinical programming to teach conditional discriminations to participants and contribute to research on designing and implementing assessments of skill-acquisition procedures.
Date:
July 2023
Creator:
Niland, Haven Sierra
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
[B.R. Brigham Monument]
Elevated view of the B.R. Brigham Monument, located on the grounds of the San Jacinto Battleground State Historic Site in La Porte, Texas.
Date:
July 7, 2022
Creator:
Hicks, William
Object Type:
Photograph
System:
The Portal to Texas History
[Battleship Texas]
Aerial photographs of the Battleship Texas, docked in La Porte, Texas.
Date:
July 7, 2022
Creator:
Hicks, William
Object Type:
Photograph
System:
The Portal to Texas History
[Battleship Texas]
Aerial photographs of the Battleship Texas, docked in La Porte, Texas.
Date:
July 7, 2022
Creator:
Hicks, William
Object Type:
Photograph
System:
The Portal to Texas History
[Battleship Texas]
Aerial photographs of the Battleship Texas, docked in La Porte, Texas.
Date:
July 7, 2022
Creator:
Hicks, William
Object Type:
Photograph
System:
The Portal to Texas History
[Battleship Texas]
Aerial footage of the Battleship Texas, docked in Site in La Porte, Texas. Video footage is silent.
Date:
July 7, 2022
Creator:
Hicks, William
Object Type:
Video
System:
The Portal to Texas History
The Baytown Sun (Baytown, Tex.), Vol. 99, No. 11, Ed. 1 Thursday, July 8, 2021
Triweekly newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
July 8, 2021
Creator:
Bloom, David
Object Type:
Newspaper
System:
The Portal to Texas History
The Baytown Sun (Baytown, Tex.), Vol. 99, No. 11, Ed. 1 Thursday, July 29, 2021
Triweekly newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
July 29, 2021
Creator:
Bloom, David
Object Type:
Newspaper
System:
The Portal to Texas History
The Baytown Sun (Baytown, Tex.), Vol. 100, No. 108, Ed. 1 Thursday, July 2, 2020
Triweekly newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
July 2, 2020
Creator:
Bloom, David
Object Type:
Newspaper
System:
The Portal to Texas History
The Baytown Sun (Baytown, Tex.), Vol. 100, No. 109, Ed. 1 Sunday, July 5, 2020
Triweekly newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
July 5, 2020
Creator:
Bloom, David
Object Type:
Newspaper
System:
The Portal to Texas History
The Baytown Sun (Baytown, Tex.), Vol. 100, No. 110, Ed. 1 Tuesday, July 7, 2020
Triweekly newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
July 7, 2020
Creator:
Bloom, David
Object Type:
Newspaper
System:
The Portal to Texas History
The Baytown Sun (Baytown, Tex.), Vol. 100, No. 111, Ed. 1 Thursday, July 9, 2020
Triweekly newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
July 9, 2020
Creator:
Bloom, David
Object Type:
Newspaper
System:
The Portal to Texas History
The Baytown Sun (Baytown, Tex.), Vol. 100, No. 112, Ed. 1 Sunday, July 12, 2020
Triweekly newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
July 12, 2020
Creator:
Bloom, David
Object Type:
Newspaper
System:
The Portal to Texas History
The Baytown Sun (Baytown, Tex.), Vol. 100, No. 113, Ed. 1 Tuesday, July 14, 2020
Triweekly newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
July 14, 2020
Creator:
Bloom, David
Object Type:
Newspaper
System:
The Portal to Texas History
The Baytown Sun (Baytown, Tex.), Vol. 100, No. 114, Ed. 1 Thursday, July 16, 2020
Triweekly newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
July 16, 2020
Creator:
Bloom, David
Object Type:
Newspaper
System:
The Portal to Texas History
The Baytown Sun (Baytown, Tex.), Vol. 100, No. 115, Ed. 1 Sunday, July 19, 2020
Triweekly newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
July 19, 2020
Creator:
Bloom, David
Object Type:
Newspaper
System:
The Portal to Texas History
The Baytown Sun (Baytown, Tex.), Vol. 100, No. 116, Ed. 1 Tuesday, July 21, 2020
Triweekly newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
July 21, 2020
Creator:
Bloom, David
Object Type:
Newspaper
System:
The Portal to Texas History
The Baytown Sun (Baytown, Tex.), Vol. 100, No. 117, Ed. 1 Thursday, July 23, 2020
Triweekly newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
July 23, 2020
Creator:
Bloom, David
Object Type:
Newspaper
System:
The Portal to Texas History
The Baytown Sun (Baytown, Tex.), Vol. 100, No. 118, Ed. 1 Sunday, July 26, 2020
Triweekly newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
July 26, 2020
Creator:
Bloom, David
Object Type:
Newspaper
System:
The Portal to Texas History
The Baytown Sun (Baytown, Tex.), Vol. 100, No. 119, Ed. 1 Tuesday, July 28, 2020
Triweekly newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
July 28, 2020
Creator:
Bloom, David
Object Type:
Newspaper
System:
The Portal to Texas History
The Baytown Sun (Baytown, Tex.), Vol. 100, No. 120, Ed. 1 Thursday, July 30, 2020
Triweekly newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
July 30, 2020
Creator:
Bloom, David
Object Type:
Newspaper
System:
The Portal to Texas History
The Baytown Sun (Baytown, Tex.), Vol. 101, No. 78, Ed. 1 Thursday, July 1, 2021
Triweekly newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
July 1, 2021
Creator:
Bloom, David
Object Type:
Newspaper
System:
The Portal to Texas History