Short-pulse, high-current discharges in vacuum were investigated with the goal to maximize the ion charge state number. In a direct extension of previous work [Appl. Phys. Lett. 92, 041502 (2008)], the role of pulse length, rate of current rise, and current amplitude was studied. For all experimental conditions, the usable (extractable) mean ion charge state could not be pushed beyond 7+. Instead, a maximum of the mean ion charge state (about 6+ to 7+ for most cathode materials) was found for a power of 2-3 MW dissipated in the discharge gap. The maximum is the result of two opposing processes that occur when the power is increased: (i) the formation of higher ion charge states, and (ii) a greater production of neutrals (both metal and non-metal), which reduces the charge state via charge exchange collisions.

Mammary gland development, functional differentiation, and homeostasis are orchestrated and sustained by a balance of biochemical and biophysical cues from the organ's microenvironment. The three-dimensional microenvironment of the mammary gland, predominantly 'encoded' by a collaboration between the extracellular matrix (ECM), hormones, and growth factors, sends signals from ECM receptors through the cytoskeletal intracellular matrix to nuclear and chromatin structures resulting in gene expression; the ECM in turn is regulated and remodeled by signals from the nucleus. In this chapter, we discuss how coordinated ECM deposition and remodeling is necessary for mammary gland development, how the ECM provides structural and biochemical cues necessary for tissue-specific function, and the role of the cytoskeleton in mediating the extra - to intracellular dialogue occurring between the nucleus and the microenvironment. When operating normally, the cytoskeletal-mediated dynamic and reciprocal integration of tissue architecture and function directs mammary gland development, tissue polarity, and ultimately, tissue-specific gene expression. Cancer occurs when these dynamic interactions go awry for an extended time.

This paper presents an international, multiple-code, simulation study of coupled thermal, hydrological, and mechanical (THM) processes and their effect on permeability and fluid flow in fractured rock around heated underground nuclear waste emplacement drifts. Simulations were conducted considering two types of repository settings: (a) open emplacement drifts in relatively shallow unsaturated volcanic rock, and (b) backfilled emplacement drifts in deeper saturated crystalline rock. The results showed that for the two assumed repository settings, the dominant mechanism of changes in rock permeability was thermal-mechanically-induced closure (reduced aperture) of vertical fractures, caused by thermal stress resulting from repository-wide heating of the rock mass. The magnitude of thermal-mechanically-induced changes in permeability was more substantial in the case of an emplacement drift located in a relatively shallow, low-stress environment where the rock is more compliant, allowing more substantial fracture closure during thermal stressing. However, in both of the assumed repository settings in this study, the thermal-mechanically-induced changes in permeability caused relatively small changes in the flow field, with most changes occurring in the vicinity of the emplacement drifts.

The extracellular matrix (ECM), once thought to solely provide physical support to a tissue, is a key component of a cell's microenvironment responsible for directing cell fate and maintaining tissue specificity. It stands to reason, then, that changes in the ECM itself or in how signals from the ECM are presented to or interpreted by cells can disrupt tissue organization; the latter is a necessary step for malignant progression. In this review, we elaborate on this concept using the mammary gland as an example. We describe how the ECM directs mammary gland formation and function, and discuss how a cell's inability to interpret these signals - whether as a result of genetic insults or physicochemical alterations in the ECM - disorganizes the gland and promotes malignancy. By restoring context and forcing cells to properly interpret these native signals, aberrant behavior can be quelled and organization re-established. Traditional imaging approaches have been a key complement to the standard biochemical, molecular, and cell biology approaches used in these studies. Utilizing imaging modalities with enhanced spatial resolution in live tissues may uncover additional means by which the ECM regulates tissue structure, on different length scales, through its pericellular organization (short-scale) and by biasing …

This simulation study shows how widely different model approaches can be adapted to model the evolution of the excavation disturbed zone (EDZ) around a heated nuclear waste emplacement drift in fractured rock. The study includes modeling of coupled thermal-hydrological-mechanical (THM) processes, with simplified consideration of chemical coupling in terms of time-dependent strength degradation or subcritical crack growth. The different model approaches applied in this study include boundary element, finite element, finite difference, particle mechanics, and elastoplastic cellular automata methods. The simulation results indicate that thermally induced differential stresses near the top of the emplacement drift may cause progressive failure and permeability changes during the first 100 years (i.e., after emplacement and drift closure). Moreover, the results indicate that time-dependent mechanical changes may play only a small role during the first 100 years of increasing temperature and thermal stress, whereas such time-dependency is insignificant after peak temperature, because decreasing thermal stress.

The Kapchinskij-Vladimirskij equations are widely used to study the evolution of the beam envelopes in a periodic system of quadrupole focusing cells. In this paper, we analyze the case of a matched beam. Our model is analogous to that used by Courant and Snyder [E.D. Courant and H.S. Snyder, Ann. Phys. 3, 1 (1958)]in obtaining a first-order approximate solution for a synchrotron. Here, we treat a linear machine and obtain an exact solution. The model uses a full occupancy, piecewise-constant focusing function and neglects space charge. There are solutions in an infinite number of bands as the focus strength is increased. We show that all these bands are stable. Our explicit results for the phase advance sigma and the envelope a(z) are exact for all phase advances except multiples of 180o, where the behavior is singular. We find that the peak envelope size is minimized at sigma = 90o. Actual operation in the higher bands would require very large, very accurate field strengths and would produce significantly larger envelope excursions.

These proceedings contain papers prepared for the 30th Monitoring Research Review: Ground-Based Nuclear Explosion Monitoring Technologies, held 23-25 September, 2008 in Portsmouth, Virginia. These papers represent the combined research related to ground-based nuclear explosion monitoring funded by the National Nuclear Security Administration (NNSA), Air Force Technical Applications Center (AFTAC), Air Force Research Laboratory (AFRL), US Army Space and Missile Defense Command, Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO), and other invited sponsors. The scientific objectives of the research are to improve the United States’ capability to detect, locate, and identify nuclear explosions. The purpose of the meeting is to provide the sponsoring agencies, as well as potential users, an opportunity to review research accomplished during the preceding year and to discuss areas of investigation for the coming year. For the researchers, it provides a forum for the exchange of scientific information toward achieving program goals, and an opportunity to discuss results and future plans. Paper topics include: seismic regionalization and calibration; detection and location of sources; wave propagation from source to receiver; the nature of seismic sources, including mining practices; hydroacoustic, infrasound, and radionuclide methods; on-site inspection; and data processing.

Low-k dielectric materials are becoming increasingly interesting as alternative to SiO2 with device geometries shrinking beyond the 65 nm technology node. At elevated temperatures hydrogen migration becomes an important degradation mechanism for conductivity breakdown in semiconductor devices. The possibility of hydrogen release during the fabrication process is, therefore, of great interest in the understanding of device reliability. In this study, various low-k dielectric films were subjected to thermal annealing at temperatures that are generally used for device fabrication. Elastic recoil detection analysis (ERDA) was used to investigate compositional changes and hydrogen redistribution in thin films of plasma-enhanced tetraethylortho-silicate (PETEOS), phosphorus doped silicon glass (PSG), silicon nitride (SiN) and silicon oxynitride (SiON). Except for an initial hydrogen release from the surface region in films of PETEOS and PSG, the results indicate that the elemental composition of the films was stable for at least 2 hours at 450◦C.

Article on the solubility of anthracene in quaternary solvent mixtures of 2,2,4-trimethylpentane + 2-propanone + methanol + alcohols at 298.15 K.

This paper presents an approach to comparing computer run time of building simulation programs. The computing run time of a simulation program depends on several key factors, including the calculation algorithm and modeling capabilities of the program, the run period, the simulation time step, the complexity of the energy models, the run control settings, and the software and hardware configurations of the computer that is used to make the simulation runs. To demonstrate the approach, simulation runs are performed for several representative DOE-2.1E and EnergyPlus energy models. The computer run time of these energy models are then compared and analyzed.

The discovery of molecular metal-metal bonds has been of fundamental importance to the understanding of chemical bonding. For the actinides, examples of unsupported metal-metal bonds are relatively uncommon, consisting of Cp{sub 3}U-SnPh{sub 3}, and several actinide-transition metal complexes. Traditionally, bonding in the f-elements has been described as electrostatic; however, elucidating the degree of covalency is a subject of recent research. In carbon monoxide complexes of the trivalent uranium metallocenes, decreased {nu}{sub CO} values relative to free CO suggest that the U(III) atom acts as a {pi}-donor. Ephritikhine and coworkers have demonstrated that {pi}-accepting ligands can differentiate trivalent lanthanide and actinide ions, an effect that renders this chemistry of interest in the context of nuclear waste separation technology.

Article on rate constants and hydrogen isotope substitution effects in the CH₃ + HCl and CH₃ + Cl₂ reactions.

The MERIT experiment, which ran at CERN in 2007, is a proof-of-principle test for a target system that converts a 4-MW proton beam into a high-intensity muon beam for either a neutrino factory complex or a muon collider. The target system is based on a free mercury jet that intercepts an intense proton beam inside a 15-T solenoidal magnetic field. Here, we describe the design and performance of the 15-T, liquid-nitrogen-precooled, copper solenoid magnet.

Driven by beam stability requirements at the NSLS II synchrotron, such that the desired small beam sizes and high brightness are both realized and stable, a comprehensive study has been launched seeking to provide assurances that stability at the nanometer level at critical x-ray beam-lines, is achievable, given the natural and cultural vibration environment at the selected site. The study consists of (a) an extensive investigation of the site to evaluate the existing ground vibration, in terms of amplitude, frequency content and coherence, and (b) of a numerical study of wave propagation and interaction with the infrastructure of the sensitive lines. The paper presents results from both aspects of the study.

Dual partial snake scheme has been used for the Brookhaven AGS (Alternating Gradient Synchrotron) polarized proton operation for several years. It has provided polarized proton beams with 1.5 x 10{sup 11} intensity and 65% polarization for RHIC spin program. There is still residual polarization loss. Several schemes such as putting horizontal tune into the spin tune gap, and injection-on-the-fly were tested in the AGS to mitigate the loss. This paper presents the experiment results and analysis.

The beam intensity of ion beams in RHIC is limited by a fast transverse instability at transition, driven by the machine impedance and electron clouds. For gold and deuteron beams we analyze the dependence of the instability threshold on beam and machine parameters from recent operational data and dedicated experiments. We fit the machine impedance to the experimental data.

State-of-the-art tracking tools were recently developed at CERN to study the cleaning efficiency of the Large Hadron Collider (LHC) collimation system. In order to estimate the prediction accuracy of these tools, benchmarking studies can be performed using actual beam loss measurements from a machine that already uses a similar multistage collimation system. This paper reviews the main results from benchmarking studies performed with specific data collected from operations at the Relativistic Heavy Ion Collider (RHIC).

The ambitious science goals of the Large Synoptic Survey Telescope (LSST) will be achieved in part by a wide-field imager that will achieve a new level of performance in terms of area, speed, and sensitivity. The instrument performance is dominated by the focal plane sensors, which are now in development. These new-generation sensors will make use of advanced semiconductor technology and will be complemented by a highly integrated electronics package located inside the cryostat. A test laboratory has been set up at Brookhaven National Laboratory (BNL) to characterize prototype sensors and to develop test and assembly techniques for eventual integration of production sensors and electronics into modules that will form the final focal plane. As described in [1], the key requirements for LSST sensors are wideband quantum efficiency (QE) extending beyond lpm in the red, control of point spread function (PSF), and fast readout using multiple amplifiers per chip operated in parallel. In addition, LSST's fast optical system (f71.25) places severe constraints on focal plane flatness. At the chip level this involves packaging techniques to minimize warpage of the silicon die, and at the mosaic level careful assembly and metrology to achieve a high coplanarity of the sensor tiles. In …

Using coarse grained models we investigate the behavior of water adjacent to an extended hydrophobic surface peppered with various fractions of hydrophilic patches of different sizes. We study the spatial dependence of the mean interface height, the solvent density fluctuations related to drying the patchy substrate, and the spatial dependence of interfacial fluctuations. We find that adding small uniform attractive interactions between the substrate and solvent cause the mean position of the interface to be very close to the substrate. Nevertheless, the interfacial fluctuations are large and spatially heterogeneous in response to the underlying patchy substrate. We discuss the implications of these findings to the assembly of heterogeneous surfaces.

In an effort to ensure that the stability goals of the NSLS II will be met once the accelerator structure is set on the selected BNL site a comprehensive evaluation of the ground vibration observed at existing light source facilities has been undertaken. The study has relied on measurement data collected and reported by the operating facilities as well as on new data collected in the course of this study. The primary goal of this comprehensive effort is to compare the green-field conditions that exist in the various sites both in terms of amplitude as well as frequency content and quantify the effect of the interaction of these accelerator facilities with the green-field vibration. The latter represents the ultimate goal of this effort where the anticipated motion of the NSLS II ring is estimated prior to its construction and compared with the required stability criteria.

The ILC Crab Cavity is positioned close to the IP and delivered luminosity is very sensitive to the wakefields induced in it by the beam. A set of couplers were designed to couple to and damp the spurious modes of the crab cavity. As the crab cavity operates using a dipole mode, it has different damping requirements from an accelerating cavity. A separate coupler is required for the monopole modes below the operating frequency of 3.9 GHz (known as the LOMs), the opposite polarization of the operating mode (the SOM), and the modes above the operating frequency (the HOMs). Prototypes of each of these couplers have been manufactured out of copper and measured attached to an aluminum nine cell prototype of the cavity and their external Q factors were measured. The results were found to agree well with numerical simulations.

Construction and magnetic field measurement of dipole magnets for RHIC-EBIS HEBT line have completed. These magnets will be used to guide highly charged ion beams ranging from proton to Uranium provided by a new injector toward the Booster ring in BNL. In this paper, overview of the magnetic design of the dipoles and results of magnetic field measurement are summarized.

To compensate the effects from the head-on beam-beam interactions in the polarized proton operation in the Relativistic Heavy Ion Collider (RHIC), an electron lens (elens) is proposed to collide head-on with the proton beam. We used an extended version of SixTrack for multiparticle beam-beam simulation in order to study the effect of the e-lens on the stochastic boundary and also on diffusion. The stochastic boundary was analyzed using Lyapunov exponents and the diffusion was characterized as the increase in the rms spread of the action. For both studies the simulations were performed with and without the e-lens and with full and partial compensation. Using the simulated values of the diffusion an attempt to calculate the emittance growth rate is presented.

The total energy loss of coasting gold ion beams was measured at RHIC at two energies, corresponding to a gamma of 75.2 and 107.4. We describe the experiment and observations and compare the measured total energy loss with expectations from ionization losses at the residual gas, the energy loss due to impedance and synchrotron radiation. We find that the measured energy losses are below what is expected from free space synchrotron radiation. We believe that this shows evidence for suppression of synchrotron radiation which is cut off at long wavelength by the presence of the conducting beam pipe.