Subclassification of ovarian carcinomas can be used to guide treatment and determine prognosis. Germline and somatic mutations, loss of heterozygosity (LOH), and epigenetic events such as promoter hypermethylation can lead to decreased expression of BRCA1/2 in ovarian cancers. The mechanism of BRCA1/2 loss is a potential method of subclassifying high grade serous carcinomas. A consecutive series of 49 ovarian cancers was assessed for mutations status of BRCA1 and BRCA2, LOH at the BRCA1 and BRCA2 loci, methylation of the BRCA1 promoter, BRCA1, BRCA2, PTEN, and PIK3CA transcript levels, PIK3CA gene copy number, and BRCA1, p21, p53, and WT-1 immunohistochemistry. Eighteen (37%) of the ovarian carcinomas had germline or somatic BRCA1 mutations, or epigenetic loss of BRCA1. All of these tumors were high-grade serous or undifferentiated type. None of the endometrioid (n=5), clear cell (n=4), or low grade serous (n=2) carcinomas showed loss of BRCA1, whereas 47% of the 38 high-grade serous or undifferentiated carcinomas had loss of BRCA1. It was possible to distinguish high grade serous carcinomas with BRCA1 mutations from those with epigenetic BRCA1 loss: tumors with BRCA1 mutations typically had decreased PTEN mRNA levels while those with epigenetic loss of BRCA1 had copy number gain of PIK3CA. Overexpression …

Twin Roll Casting (TRC) is a process by which thin strip is produced directly from molten metal. This process has many advantages over traditional Direct Chill (DC) casting where metal is cast into large slabs or ingots and subsequently hot and cold rolled into strips. While the DC casting involves large capital investment and energy consumption, TRC produces strip with thickness in the range of 10 mm to 2.5 mm in one operation without hot rolling, with less cost, energy usage and equipment requirements. In TRC AA3105, high solidification and post-solidification cooling rates lead to high manganese supersaturation throughout the as-cast strip and very fine constituent particles near strip surface. After 90% cold rolling, the TRC material shows sluggish recrystallization kinetics and a very coarse grain structure, due to concurrent forming dispersoids and/or fine constituent particles. These particles interfere with the nucleation process by preventing migration of the boundaries associated with potential nuclei, resulting in fewer recrystallization nuclei and slower nucleation rate. In addition, the fine particles can impede grain growth by exerting a pinning pressure on moving boundaries. The current study investigated the microstructure evolution in TRC AA3105 during different thermo-mechanical treatments. A systematic study of the effects of …

Three independent methods (XUV spectroscopy, imaging at 68 eV and 256 eV) have been used to measure planar target rear surface plasma temperature due to heating by hot electrons. The hot electrons are produced by ultra-intense laser plasma interactions using the 150 J, 0.5 ps Titan laser. Soft x-ray spectroscopy in the 50-400 eV region and imaging at the 68 eV and 256 eV photon energies were used to determine the rear surface temperature of planar CD targets. Temperatures were found to be in the 60-150 eV range, with good agreement between the three diagnostics.

A Bremsstrahlung spectrometer using k-edge and differential filtering has been used with Image Plate dosimeters to measure the x-ray fluence from short-pulse laser/target interactions. An electron spectrometer in front of the Bremsstrahlung spectrometer deflects electrons from the x-ray line of sight and simultaneously measures the electron spectrum. The response functions were modeled with the Monte Carlo code Integrated Tiger Series 3.0 and the dosimeters calibrated with radioactive sources. Electron distributions with slope temperatures in the MeV range are inferred from the Bremsstrahlung spectra.

Results of radiation damage in Pu and Pu{sub 1-x}Am{sub x} alloys studied with magnetic susceptibility, {chi}(T), and resistivity are presented. Damage accumulated at low temperatures increases {chi}(T) for all measured alloys, with the trend generally enhanced as the lattice expands. There is a trend towards saturation observable in the damage induced magnetic susceptibility data, that is not evident in similar damage induced resistivity data taken on the same specimen. A comparison of isochronal annealing curves measured by both resistivity and magnetic susceptibility on a 4.3at% Ga stabilized {delta}-Pu specimen show that Stage I annealing, where interstitials begin to move, is largely transparent to the magnetic measurement. This indicates that interstitials have little impact on the damage induced increase in the magnetic susceptibility. The isochronal annealing curves of the Pu{sub 1-x}Am{sub x} alloys do not show distinct annealing stages as expected for alloys. However, samples near 20% Am concentration show an unexpected increase in magnetization beginning when specimens are annealed to 35K. This behavior is also reflected in a time dependent increase in the magnetic susceptibility of damaged specimens indicative of first order kinetics. These results suggest there may be a metastable phase induced by radiation damage and annealing in Pu{sub …

Motional Stark effect (MSE) measurements constrain equilibrium reconstruction of DIII-D tokamak plasmas using the equilibrium code EFIT. In 2007, two new MSE arrays were brought online, bringing the system to three core arrays, two edge arrays, and 64 total channels. We present the first EFIT reconstructions using this expanded system. Safety factor and E{sub R} profiles produced by fitting to data from the two new arrays and one of the other three agree well with independent measurements. Comparison of the data from the three arrays that view the core shows that one of the older arrays is inconsistent with the other two unless the measured calibration factors for this array are adjusted. The required adjustments depend on toroidal field and plasma current direction, and on still other uncertain factors that change as the plasma evolves. We discuss possible sources of calibration error for this array.

The authors use a sample of 384 million B{bar B} events collected with the BABAR detector at the PEP-II e{sup +}e{sup -} collider to study angular distributions in the rare decays B {yields} K*{ell}{sup +}{ell}{sup -}, where {ell}{sup +}{ell}{sup -} is either e{sup +}e{sup -} or {mu}{sup +}{mu}{sup -}. For low dilepton invariant masses, m{sub {ell}{ell}} < 2.5 GeV/c{sup 2}, they measure a lepton forward-backward asymmetry {Alpha}{sub FB} = 0.24{sub -0.23}{sup +0.18} {+-} 0.05 and K* longitudinal polarization F{sub L} = 0.35 {+-} 0.16 {+-} 0.04. For m{sub {ell}{ell}} > 3.2 GeV/c{sup 2}, they measure {Alpha}{sub FB} = 0.76{sub -0.32}{sup +0.52} {+-} 0.07 and F{sub L} = 0.71{sub -0.22}{sup 0.20} {+-} 0.04.

TeV-blazars are known as prominent non-thermal emitters across the entire electromagnetic spectrum with their photon power peaking in the X-ray and TeV-band. If distant, absorption of -ray photons by the extragalactic background light (EBL) alters the intrinsic TeV spectral shape, thereby affecting the overall interpretation. Suzaku observations for two of the more distant TeV-blazars known to date, 1ES 1101-232 and 1ES 1553+113, were carried out in May and July 2006, respectively, including a quasi-simultaneous coverage with the state of the art Cherenkov telescope facilities. We report on the resulting data sets with emphasis on the X-ray band, and set into context to their historical behavior. During our campaign, we did not detect any significant X-ray or {gamma}-ray variability. 1ES 1101-232 was found in a quiescent state with the lowest X-ray flux ever measured. The combined XIS and HXD PIN data for 1ES 1101-232 and 1ES 1553+113 clearly indicate spectral curvature up to the highest hard X-ray data point ({approx} 30 keV), manifesting as softening with increasing energy. We describe this spectral shape by either a broken power law or a log-parabolic fit with equal statistical goodness of fits. The combined 1ES 1553+113 very high energy spectrum (90-500 GeV) did not …

Two layers of insulation fill the volume of the 9977 package between the drum liner and the shell. One of these layers is composed of General Plastics FR-3716 polyurethane foam (also known as Last-A-Foam{reg_sign}), poured through fill holes in the drum bottom and foamed in place. There was concern that the density of the foam insulating layer may vary due to the manufacturing process and that variations in foam density would compromise the safety basis of the package. Thus, a structural finite element analysis was performed to investigate this concern. The investigation examined the effect of replacing the material properties for the FR-3716 polyurethane foam, which has a density equal to 16 lb{sub m}/ft{sup 3}, with material properties of similar foam with varying densities through finite element analysis of hypothetical accident conditions (HAC) pertaining to impact conditions. The results showed that the functional performance of the containment vessel (CV) was not compromised under the conditions investigated.

Babel is a tool aimed at the high-performance computing community that addresses the need for mixing programming languages (Java, Python, C, C++, Fortran 90, FORTRAN 77) in order to leverage the specific benefits of those languages. Scientific codes often rely on structured data types (structs, derived data types) to encapsulate data, and Babel has been lacking in this type of support until recently. We present a new language binding that focuses on their interoperability of C/C++ with Fortran 2003. The new binding builds on the existing Fortran 90 infrastructure by using the iso-c-binding module defined in the Fortran 2003 standard as the basis for C/C++ interoperability. We present the technical approach for the new binding and discuss our initial experiences in applying the binding in FACETS (Framework Application for Core-Edge Transport Simulations) to integrate C++ with legacy Fortran codes.

Assuming that Dark Matter is dominated by WIMPs, it accretes by gravitational attraction and scattering over baryonic material and annihilates inside celestial objects, giving rise to a 'Dark Luminosity' which may potentially affect the evolution of stars. We estimate the Dark Luminosity achieved by different kinds of stars in a halo with DM properties characteristic of the ones where the first star formation episode occurs. We find that either massive, metal-free and small, galactic-like stars can achieve Dark Luminosities comparable or exceeding their nuclear ones. This might have dramatic effects over the evolution of the very first stars, known as Population III.

Hydrogen promises to be an attractive transportation fuel in the post-fossil fuel era. Relatively abundant and clean burning (water being the principal byproduct), hydrogen offers the potential to significantly reduce greenhouse gas emissions. However, there are significant technical barriers that require solutions before hydrogen can be implemented in large scale. These are: · Sources (e.g. hydrocarbon, water) · Transportation · Storage Each of the aforementioned barriers carries with it important considerations. First, would a hydrocarbon-based hydrogen source be of any benefit compared to conventional fossil fuels? Second, will a system based on centralized generation and distribution be viable? Finally, methods of on-board storage, whether they are liquefaction, adsorption, or intercalation, are far from optimized. The scope of this program is limited to hydrogen generation, specifically generation using solarinitiated water electrolysis. Though concept of making hydrogen using water and sunlight may sound somewhat far-fetched, in reality the concept is very real. Since the discovery of solar-generated hydrogen, termed photoelectrochemical hydrogen, nearly 30 years ago by Fujishima and Honda, significant advances in both fundamental understanding and technological capability have been made. Using solar radiation to generate hydrogen in a fashion akin to using solar to generate electricity offers many advantages. First, hydrogen …

Free weekly newspaper that includes business and classified advertising.

Free weekly newspaper that includes business and classified advertising.

This report discusses disaster relief for commercial fishery, which be provided by the federal government to assist the fishing industry when it is affected by a commercial fishery failure.

Weekly newspaper from Dallas, Texas that includes local, state, and national news and advertising of interest to the Lesbian, Gay, Bisexual, and Transgender (LGBT) community.

This report provides background information about the war in Kosovo and discusses issues regarding Kosovo's future status and U. S. policy.

Letter from Isabel Zermeno to Lisa Thomas on May 2, 2008, discussing details for the caucus meeting at the Texas Democratic Party's 2008 State Convention.

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This report first discusses the current state of the economy, including measures that have already been taken by the monetary authorities, and assesses the need for and potential consequences of fiscal stimulus. The second part of the report reviews the proposals discussed during debate on the recently enacted fiscal stimulus, both those adopted and those considered but not adopted. The various stimulus packages differed somewhat, and the report briefly describes those differences. This section includes a discussion of the potential elements of a second stimulus proposal and concludes with a discussion of the macroeconomic effects of the proposals.

Weekly newspaper from Dell City, Texas that includes local, state, and national news along with advertising.

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The National Museum of the Pacific War presents an interview with George William Ogden. Ogden joined the Navy in February of 1942. He completed Officer Candidate School, and trained with amphibious landing vehicles. Beginning in early 1943, he served as a Communications Officer aboard the USS LST-172. They traveled to Guantanamo Bay, Bora Bora, Samoa, New Hebrides, New Caledonia and Guadalcanal. They assisted the Marines in preparation for the Battle of Okinawa. He continued his service after the war ended, and was discharged in May of 1946.