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Accumulation and altered localization of telomere-associated protein TRF2 in immortally transformed and tumor-derived human breast cells
We have used cultured human mammary epithelial cells (HMEC) and breast tumor-derived lines to gain information on defects that occur during breast cancer progression. HMEC immortalized by a variety of agents (the chemical carcinogen benzo(a)pyrene, oncogenes c-myc and ZNF217, and/or dominant negative p53 genetic suppressor element GSE22) displayed marked up regulation (10-15 fold) of the telomere binding protein, TRF2. Up-regulation of TRF2 protein was apparently due to differences in post-transcriptional regulation, as mRNA levels remained comparable in finite life span and immortal HMEC. TRF2 protein was not up-regulated by the oncogenic agents alone in the absence of immortalization, nor by expression of exogenously introduced hTERT genes. We found TRF2 levels to be at least 2-fold higher than in control cells in 11/15 breast tumor cell lines, suggesting that elevated TRF2 levels are a frequent occurrence during the transformation of breast tumor cells in vivo. The dispersed distribution of TRF2 throughout the nuclei in some immortalized and tumor-derived cells indicated that not all the TRF2 was associated with telomeres in these cells. The process responsible for accumulation of TRF2 in immortalized HMEC and breast tumor-derived cell lines may promote tumorigenesis by contributing to the cells ability to maintain an indefinite life …
Date:
December 23, 2004
Creator:
Nijjar, Tarlochan; Bassett, Ekaterina; Garbe, James; Takenaka, Yasuhiro; Stampfer, Martha R.; Gilley, David et al.
Object Type:
Article
System:
The UNT Digital Library
The Albany News (Albany, Tex.), Vol. 129, No. 30, Ed. 1 Thursday, December 23, 2004
Weekly newspaper from Albany, Texas that includes local, county, and state news along with extensive advertising.
Date:
December 23, 2004
Creator:
Lucas, Melinda L.
Object Type:
Newspaper
System:
The Portal to Texas History
Altus Times (Altus, Okla.), Vol. 106, No. 221, Ed. 1 Thursday, December 23, 2004
Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date:
December 23, 2004
Creator:
Andrews, Mike
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Amtrak: The Political and Social Aspects of Federal Intercity Passenger Rail Policy
This report is on Amtrak: The Political and Social Aspects of Federal Intercity Passenger Rail Policy.
Date:
December 23, 2004
Creator:
Frittelli, John & Kirk, Robert S.
Object Type:
Report
System:
The UNT Digital Library
Archer County News (Archer City, Tex.), No. 52, Ed. 1 Thursday, December 23, 2004
Weekly newspaper from Archer City, Texas that includes local, state, and national news along with advertising.
Date:
December 23, 2004
Creator:
Lewis, Shelley
Object Type:
Newspaper
System:
The Portal to Texas History
B physics: measurement of the j/psi meson and b-hadron production cross sections in p anti-p collisions at s**(1/2) = 1960 gev
The authors present a new measurement of the inclusive and differential production cross sections of J/{psi} mesons and b-hadrons in proton-antiproton collisions at {radical}s = 1960 GeV. The data correspond to an integrated luminosity of 39.7 pb{sup -1} collected by the CDF Run II detector. They find the integrated cross section for inclusive J/{psi} production for all transverse momenta from 0 to 20 GeV/c in the rapidity range |y| < 0.6 to be 4.08 {+-} 0.02(stat){sub -0.33}{sup +0.36}(syst) {mu}b. They separate the fraction of J/{psi} events from the decay of the long-lived b-hadrons using the lifetime distribution in all events with p{sub T}(J/{psi}) > 1.25 GeV/c. They find the total cross section for b-hadrons, including both hadrons and anti-hadrons, decaying to J/{psi} with transverse momenta greater than 1.25 GeV/c in the rapidity range |y(J/{psi})| < 0.6, is 0.330 {+-} 0.005(stat){sub -0.033}{sup +0.036}(syst) {mu}b. Using a Monte Carlo simulation of the decay kinematics of b-hadrons to all final states containing a J/{psi}, they extract the first measurement of the total single b-hadron cross section down to zero transverse momentum at {radical}s = 1960 GeV. They find the total single b-hadron cross section integrated over all transverse momenta for b-hadrons in the …
Date:
December 23, 2004
Creator:
Acosta, D.
Object Type:
Article
System:
The UNT Digital Library
The Baytown Sun (Baytown, Tex.), Vol. 84, No. 18, Ed. 1 Thursday, December 23, 2004
Daily newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
December 23, 2004
Creator:
Cash, Wanda Garner
Object Type:
Newspaper
System:
The Portal to Texas History
The Canadian Record (Canadian, Tex.), Vol. 114, No. 52, Ed. 1 Thursday, December 23, 2004
Weekly newspaper from Canadian, Texas that includes local, state and national news along with some advertising.
Date:
December 23, 2004
Creator:
Brown, Laurie Ezzell
Object Type:
Newspaper
System:
The Portal to Texas History
Cooper Review (Cooper, Tex.), Vol. 124, No. 52, Ed. 1 Thursday, December 23, 2004
Weekly newspaper from Cooper, Texas that includes local, state, and national news along with advertising.
Date:
December 23, 2004
Creator:
Pinson, Beth
Object Type:
Newspaper
System:
The Portal to Texas History
DNA Testing for Law Enforcement: Legislative Issues for Congress
This report discusses DNA testing for law enforcement, identifies issues with such testing and the congressional and Administration response to the issues.
Date:
December 23, 2004
Creator:
Hill, Cindy
Object Type:
Report
System:
The UNT Digital Library
The Dublin Citizen (Dublin, Tex.), Vol. 15, No. 17, Ed. 1 Thursday, December 23, 2004
Weekly newspaper from Dublin, Texas that includes local, state, and national news along with advertising.
Date:
December 23, 2004
Creator:
unknown
Object Type:
Newspaper
System:
The Portal to Texas History
Education Reform in Pakistan
This report reviews education reform efforts in pakistan and U.S. assistance, and includes discussion of current policy.
Date:
December 23, 2004
Creator:
Kronstadt, K. Alan
Object Type:
Report
System:
The UNT Digital Library
Electra Star-News (Electra, Tex.), Vol. 98, No. 19, Ed. 1 Thursday, December 23, 2004
Weekly newspaper from Electra, Texas that includes local, state, and national news along with advertising.
Date:
December 23, 2004
Creator:
unknown
Object Type:
Newspaper
System:
The Portal to Texas History
Electric Reliability: Options for Electric Transmission Infrastructure Improvements
The electric utility industry is inherently capital intensive. At the same time, the industry must operate under a changing and sometimes unpredictable regulatory system at both the federal and state level. The Energy Policy Act of 2005 has set in place government activities intended to relieve congestion on the transmission system. Several factors have contributed to the lack of new transmission capacity; these are outlined within this report. This report also discusses earlier pieces of energy legislation.
Date:
December 23, 2004
Creator:
Abel, Amy
Object Type:
Report
System:
The UNT Digital Library
Electric Reliability: Options for Electric Transmission Infrastructure Improvements
The electric utility industry is inherently capital intensive. At the same time, the industry must operate under a changing and sometimes unpredictable regulatory system at both the federal and state level. The Energy Policy Act of 2005 has set in place government activities intended to relieve congestion on the transmission system. Several factors have contributed to the lack of new transmission capacity; these are outlined within this report. This report also discusses earlier pieces of energy legislation.
Date:
December 23, 2004
Creator:
Abel, Amy
Object Type:
Report
System:
The UNT Digital Library
Energy Policy: The Continuing Debate and Omnibus Energy Legislation
This report includes background and analysis of energy policy. Points of discussion include the Arctic National Wildlife Refuge, nuclear energy, and renewable energy and fuels.
Date:
December 23, 2004
Creator:
Bamberger, Robert L.
Object Type:
Report
System:
The UNT Digital Library
Establishment of an Industry-Driven Consortium Focused on Improving the Production Performance of Domestic Stripper Wells Quarterly Report
The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the fifteenth quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) hosting the SWC spring proposal meeting in Golden Colorado, (2) planning of the upcoming SWC fall technology transfer meetings, and (3) recruiting the SWC base membership.
Date:
December 23, 2004
Creator:
Morrison, Joel L.
Object Type:
Report
System:
The UNT Digital Library
The Express-Star (Chickasha, Okla.), Ed. 1 Thursday, December 23, 2004
Daily newspaper from Chickasha, Oklahoma that includes local, state, and national news along with advertising.
Date:
December 23, 2004
Creator:
Bush, Kent
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
[Funeral Program for Imojean Miller Stephens, December 23, 2004]
Funeral program for Mrs. Imojean Miller Stephens, born January 2, 1931 and died December 20, 2004. The funeral was held December 23, 2004 at Greater New Mt. Zion Baptist Church, officiated by Rev. Jesse T. Hardeman. Funeral arrangements were made through D. W. Brooks Funeral Home, and she was buried in Fort Sam Houston National Cemetery near San Antonio, Texas.
Date:
December 23, 2004
Creator:
unknown
Object Type:
Pamphlet
System:
The Portal to Texas History
Garber Billings News (Garber, Okla.), Vol. 105, No. 10, Ed. 1 Thursday, December 23, 2004
Weekly newspaper from Garber, Oklahoma that includes local, state, and national news along with advertising.
Date:
December 23, 2004
Creator:
Hogan, Vickie Lee
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Gasoline Price Surge Revisited: Crude Oil and Refinery Issues
None
Date:
December 23, 2004
Creator:
Kumins, Lawrence & Bamberger, Robert
Object Type:
Report
System:
The UNT Digital Library
Homeland Security: Federal Assistance Funding and Business Opportunities
This report provides a selection of information gateways for businesses, state and local governments, research organizations, and others that wish to pursue homeland security related business opportunities or grants from the federal government.
Date:
December 23, 2004
Creator:
Riehl, James R.
Object Type:
Report
System:
The UNT Digital Library
Hondo Anvil Herald (Hondo, Tex.), Vol. 118, No. 52, Ed. 1 Thursday, December 23, 2004
Weekly newspaper from Hondo, Texas that includes local, state, and national news along with extensive advertising.
Date:
December 23, 2004
Creator:
unknown
Object Type:
Newspaper
System:
The Portal to Texas History
Iraq: Summary of U.S. Casualties
This report provides statistics on fatalities during Operation Iraqi Freedom, which began on March 19, 2003, as well as on the number of fatalities since May 1, 2003, plus statistics on those wounded, but not killed, since March 19, 2003.
Date:
December 23, 2004
Creator:
Fischer, Hannah
Object Type:
Report
System:
The UNT Digital Library