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Inhibition of heregulin expression blocks tumorigenicity and metastasis of breast cancer (open access)

Inhibition of heregulin expression blocks tumorigenicity and metastasis of breast cancer

The growth factor Heregulin (HRG) is expressed in 30% of breast cancer tumors. HRG induces tumorigenicity and metastasis of breast cancer cells. Our investigation into whether blockage of HRG reduces the aggressiveness of breast cancer cells demonstrated that transfection of MDA-MB-231 with an HRG antisense cDNA suppressed proliferation, tumorigenicity, and metastasis. Blockage of the aggressive phenotype is mediated possibly through inactivation of the erbB signaling pathways and a decrease in MMP-9 activity. Our study is the first to report that HRG is a key promoter of breast cancer progression and should be deemed as a potential target in developing therapies for the treatment of breast carcinomas.
Date: December 20, 2001
Creator: Tsai, Miaw-Sheue; Shamon-Taylor, Lisa A.; Mehmi, Inderjit; Tang, Careen K.; Cardillo, Marina & Lupu, Ruth
Object Type: Article
System: The UNT Digital Library
Inspectors General: Department of Defense IG Peer Reviews (open access)

Inspectors General: Department of Defense IG Peer Reviews

Correspondence issued by the General Accounting Office with an abstract that begins "The 1997 peer review of the Department of Defense (DOD) Inspector General (IG) done by the Environmental Protection Agency IG resulted in a qualified opinion. The peer review report questioned the quality assurance system used by the DOD IG and said that the reviewed audits did not fully comply with Government Auditing Standards. The 2000 peer review done by the Department of the Treasury IG for Tax Administration (TIGTA) also resulted in a unqualified opinion. Although TIGTA cited several problems, the peer review report concluded that the quality assurance system used by the DOD IG reasonably ensured compliance with auditing standards. However, after the peer review had been completed, a letter was sent to Congress, the press, and others questioning the integrity of the documentation that the DOD IG provided to the TIGTA peer review staff. A DOD IG internal investigation later confirmed that the work papers for one of the audits chosen for peer review had been altered and destroyed. The report concluded that these actions violated Government Auditing Standards, internal DOD IG audit policies, and the expectations of the external peer review staff. TIGTA then withdrew …
Date: December 20, 2001
Creator: United States. General Accounting Office.
Object Type: Text
System: The UNT Digital Library
Intelligent monitoring and analysis for safeguards applications. (open access)

Intelligent monitoring and analysis for safeguards applications.

None
Date: December 20, 2001
Creator: Laurin-Kovitz, K.F. & Ewing, T.F.
Object Type: Article
System: The UNT Digital Library
The Leonard Graphic (Leonard, Tex.), Vol. 111, No. 51, Ed. 1 Thursday, December 20, 2001 (open access)

The Leonard Graphic (Leonard, Tex.), Vol. 111, No. 51, Ed. 1 Thursday, December 20, 2001

Weekly newspaper from Leonard, Texas that includes local, state, and national news along with advertising.
Date: December 20, 2001
Creator: unknown
Object Type: Newspaper
System: The Portal to Texas History
Limitations of science and adaptive management (open access)

Limitations of science and adaptive management

Adaptive management consists in patterning human sustenancewithin the constraints of Earth and biological systems whose behavior isinherently uncertain and difficult to control. For successful adaptivemanagement, a mind-set recognizing the limitations of science isneeded.
Date: December 20, 2001
Creator: Narasimhan, T.N.
Object Type: Article
System: The UNT Digital Library
Mount Vernon Optic-Herald (Mount Vernon, Tex.), Vol. 127, No. 20, Ed. 1 Thursday, December 20, 2001 (open access)

Mount Vernon Optic-Herald (Mount Vernon, Tex.), Vol. 127, No. 20, Ed. 1 Thursday, December 20, 2001

Weekly newspaper from Mount Vernon, Texas that includes local, state, and national news along with advertising.
Date: December 20, 2001
Creator: Bush-Reves, Lillie
Object Type: Newspaper
System: The Portal to Texas History
Multi-Scale Thermohydrologic Model Sensitivity-Study Calculations in Support of the SSPA (open access)

Multi-Scale Thermohydrologic Model Sensitivity-Study Calculations in Support of the SSPA

The purpose of this calculation report is to document the thermohydrologic (TH) model calculations performed for the Supplemental Science and Performance Analysis (SSPA), Volume 1, Section 5 and Volume 2 (BSC 2001d [DIRS 155950], BSC 2001e [DIRS 154659]). The calculations are documented here in accordance with AP-3.12Q REV0 ICN4 [DIRS 154418]. The Technical Working Plan (Twp) for this document is TWP-NGRM-MD-000015 Real. These TH calculations were primarily conducted using three model types: (1) the Multiscale Thermohydrologic (MSTH) model, (2) the line-averaged-heat-source, drift-scale thermohydrologic (LDTH) model, and (3) the discrete-heat-source, drift-scale thermal (DDT) model. These TH-model calculations were conducted to improve the implementation of the scientific conceptual model, quantify previously unquantified uncertainties, and evaluate how a lower-temperature operating mode (LTOM) would affect the in-drift TH environment. Simulations for the higher-temperature operating mode (HTOM), which is similar to the base case analyzed for the Total System Performance Assessment for the Site Recommendation (TSPA-SR) (CRWMS M&O 2000j [DIRS 153246]), were also conducted for comparison with the LTOM. This Calculation Report describes (1) the improvements to the MSTH model that were implemented to reduce model uncertainty and to facilitate model validation, and (2) the sensitivity analyses conducted to better understand the influence of parameter …
Date: December 20, 2001
Creator: Glascoe, L G; Buscheck, T A; Loosmore, G A & Sun, Y
Object Type: Report
System: The UNT Digital Library
The Oklahoma Eagle (Tulsa, Okla.), Vol. 80, No. 52, Ed. 1 Thursday, December 20, 2001 (open access)

The Oklahoma Eagle (Tulsa, Okla.), Vol. 80, No. 52, Ed. 1 Thursday, December 20, 2001

Weekly newspaper from Tulsa, Oklahoma that includes local, state, and national news along with advertising.
Date: December 20, 2001
Creator: unknown
Object Type: Newspaper
System: The Gateway to Oklahoma History
Oral History Interview with Frederick Vinson, December 20, 2001 transcript

Oral History Interview with Frederick Vinson, December 20, 2001

The National Museum of the Pacific War presents an interview with Frederick Vinson. Vinson joined the Navy in March of 1942. He completed Midshipmen’s school, Recognition school and Gunnery school. He was assigned to Destroyer Squadron 25. Vinson served as a Lieutenant Senior Grade Squadron Gunnery Officer aboard the USS John Rodgers (DD-574). In 1943 they raided Marcus Island, Tarawa and Wake Island, participated in the Bougainville and Gilbert Islands campaigns. Going into 1944 they were involved with the Marshall Islands Campaign, the Battle of Kwajalein, the Guadalcanal Campaign and the Battle of Guam where they received a commendation for their work. They continued on through the Battle of Leyte Gulf. In 1945 they participated in the Battles of Iwo Jima and Okinawa. Vinson provides vivid details of his experiences through each of these battles. He was discharged in September of 1945.
Date: December 20, 2001
Creator: Vinson, Frederick
Object Type: Sound
System: The Portal to Texas History
Oral History Interview with Frederick Vinson, December 20, 2001 (open access)

Oral History Interview with Frederick Vinson, December 20, 2001

The National Museum of the Pacific War presents an interview with Frederick Vinson. Vinson joined the Navy in March of 1942. He completed Midshipmen’s school, Recognition school and Gunnery school. He was assigned to Destroyer Squadron 25. Vinson served as a Lieutenant Senior Grade Squadron Gunnery Officer aboard the USS John Rodgers (DD-574). In 1943 they raided Marcus Island, Tarawa and Wake Island, participated in the Bougainville and Gilbert Islands campaigns. Going into 1944 they were involved with the Marshall Islands Campaign, the Battle of Kwajalein, the Guadalcanal Campaign and the Battle of Guam where they received a commendation for their work. They continued on through the Battle of Leyte Gulf. In 1945 they participated in the Battles of Iwo Jima and Okinawa. Vinson provides vivid details of his experiences through each of these battles. He was discharged in September of 1945.
Date: December 20, 2001
Creator: Vinson, Frederick
Object Type: Text
System: The Portal to Texas History
Oral History Interview with Manuel Garcia, December 20, 2001 transcript

Oral History Interview with Manuel Garcia, December 20, 2001

The National Museum of the Pacific War presents an oral interview with Manuel Garcia. Garcia was born in Goliad, Texas on 11 June 1920. He attended the Rincon Bend County School, a segregated school, until the seventh grade. In 1940, he joined the Army and underwent basic training at Fort Sam Houston, Texas. He was then assigned to the 2nd Infantry Division, 38th Infantry Regiment. The division moved to Camp McCoy, Wisconsin. In 1943 the division went to Camp Shanks, New York where they boarded a ship bound for Ireland. After ten months of intensive training the division participated in Operation Overlord, landing on Omaha Beach on June 7 1944. Garcia describes leaving the transport ship to land on the beach and seeing wreckage and bodies stacked like wood. He was slightly wounded and went to a field hospital for treatment. Several days later he was severely wounded by German artillery fire. After being taken to another field hospital, he was placed aboard a Piper Cub and flown to the Army hospital in Cheltenham, England where surgeons amputated one of his legs. Garcia returned to the United States by a hospital ship and was placed in several military hospitals until …
Date: December 20, 2001
Creator: Garcia, Manuel
Object Type: Sound
System: The Portal to Texas History
Oral History Interview with Manuel Garcia, December 20, 2001 (open access)

Oral History Interview with Manuel Garcia, December 20, 2001

The National Museum of the Pacific War presents an oral interview with Manuel Garcia. Garcia was born in Goliad, Texas on 11 June 1920. He attended the Rincon Bend County School, a segregated school, until the seventh grade. In 1940, he joined the Army and underwent basic training at Fort Sam Houston, Texas. He was then assigned to the 2nd Infantry Division, 38th Infantry Regiment. The division moved to Camp McCoy, Wisconsin. In 1943 the division went to Camp Shanks, New York where they boarded a ship bound for Ireland. After ten months of intensive training the division participated in Operation Overlord, landing on Omaha Beach on June 7 1944. Garcia describes leaving the transport ship to land on the beach and seeing wreckage and bodies stacked like wood. He was slightly wounded and went to a field hospital for treatment. Several days later he was severely wounded by German artillery fire. After being taken to another field hospital, he was placed aboard a Piper Cub and flown to the Army hospital in Cheltenham, England where surgeons amputated one of his legs. Garcia returned to the United States by a hospital ship and was placed in several military hospitals until …
Date: December 20, 2001
Creator: Garcia, Manuel
Object Type: Text
System: The Portal to Texas History
Oral History Interview with Robert Gwynn, December 20, 2001 transcript

Oral History Interview with Robert Gwynn, December 20, 2001

The National Museum of the Pacific War presents an oral interview with Robert Gwynn. Gwynn was born 8 October 1921 in Lima, Ohio. Joining the Army Air Corps 28 October 1940, he took basic training at March Field, California. He entered the enlisted pilot training program in December 1941. Upon graduating he received his staff sergeant rating and went to Wisconsin for C-47 transition. Upon completing the course he was assigned to Bergstrom Air Force Base, Austin, Texas. After a period of time he went to Florida where he received his instrument rating. He recalls participating in the invasion of Sicily on 10 July 1943 and comments on the high loss of aircraft that occurred. Gwynn also dropped paratroopers during the invasion of Anzio. He remembers witnessing from afar the German air raid on Bari, Italy during which 17 ships were sunk. On 6 June 1944 he piloted aircraft which dropped paratroopers over France. On 8 May 1945 he returned home and was discharged. He tells of being recalled in 1949 and participating in the Berlin Airlift.
Date: December 20, 2001
Creator: Gwynn, Robert
Object Type: Sound
System: The Portal to Texas History
Oral History Interview with Robert Gwynn, December 20, 2001 (open access)

Oral History Interview with Robert Gwynn, December 20, 2001

The National Museum of the Pacific War presents an oral interview with Robert Gwynn. Gwynn was born 8 October 1921 in Lima, Ohio. Joining the Army Air Corps 28 October 1940, he took basic training at March Field, California. He entered the enlisted pilot training program in December 1941. Upon graduating he received his staff sergeant rating and went to Wisconsin for C-47 transition. Upon completing the course he was assigned to Bergstrom Air Force Base, Austin, Texas. After a period of time he went to Florida where he received his instrument rating. He recalls participating in the invasion of Sicily on 10 July 1943 and comments on the high loss of aircraft that occurred. Gwynn also dropped paratroopers during the invasion of Anzio. He remembers witnessing from afar the German air raid on Bari, Italy during which 17 ships were sunk. On 6 June 1944 he piloted aircraft which dropped paratroopers over France. On 8 May 1945 he returned home and was discharged. He tells of being recalled in 1949 and participating in the Berlin Airlift.
Date: December 20, 2001
Creator: Gwynn, Robert
Object Type: Text
System: The Portal to Texas History
PDE-based Non-Linear Diffusion Techniques for Denoising Scientific and Industrial Images: An Empirical Study (open access)

PDE-based Non-Linear Diffusion Techniques for Denoising Scientific and Industrial Images: An Empirical Study

Removing noise from data is often the first step in data analysis. Denoising techniques should not only reduce the noise, but do so without blurring or changing the location of the edges. Many approaches have been proposed to accomplish this; in this paper, they focus on one such approach, namely the use of non-linear diffusion operators. This approach has been studied extensively from a theoretical viewpoint ever since the 1987 work of Perona and Malik showed that non-linear filters outperformed the more traditional linear Canny edge detector. They complement this theoretical work by investigating the performance of several isotropic diffusion operators on test images from scientific domains. They explore the effects of various parameters such as the choice of diffusivity function, explicit and implicit methods for the discretization of the PDE, and approaches for the spatial discretization of the non-linear operator etc. They also compare these schemes with simple spatial filters and the more complex wavelet-based shrinkage techniques. The empirical results show that, with an appropriate choice of parameters, diffusion-based schemes can be as effective as competitive techniques.
Date: December 20, 2001
Creator: Weeratunga, S K & Kamath, C
Object Type: Article
System: The UNT Digital Library
Polarization Studies in Fast-Ion Beam Spectroscopy (open access)

Polarization Studies in Fast-Ion Beam Spectroscopy

In a historical review, the observations and the insight gained from polarization studies of fast ions interacting with solid targets are presented. These began with J. Macek's recognition of zero-field quantum beats in beam-foil spectroscopy as indicating alignment, and D.G. Ellis' density operator analysis that suggested the observability of orientation when using tilted foils. Lastly H. Winter's studies of the ion-beam surface interaction at grazing incidence yielded the means to produce a high degree of nuclear orientation in ion beams.
Date: December 20, 2001
Creator: Trabert, E
Object Type: Article
System: The UNT Digital Library
Polk County Enterprise (Livingston, Tex.), Vol. 119, No. 101, Ed. 1 Thursday, December 20, 2001 (open access)

Polk County Enterprise (Livingston, Tex.), Vol. 119, No. 101, Ed. 1 Thursday, December 20, 2001

Semi-weekly newspaper from Livingston, Texas that includes local, state and national news along with advertising.
Date: December 20, 2001
Creator: White, Barbara
Object Type: Newspaper
System: The Portal to Texas History
Port Aransas South Jetty (Port Aransas, Tex.), Vol. 31, No. 51, Ed. 1 Thursday, December 20, 2001 (open access)

Port Aransas South Jetty (Port Aransas, Tex.), Vol. 31, No. 51, Ed. 1 Thursday, December 20, 2001

Weekly newspaper from Port Aransas, Texas on Mustang Island that includes local, state and national news along with advertising.
Date: December 20, 2001
Creator: Judson, Mary
Object Type: Newspaper
System: The Portal to Texas History
POWs and MIAs: Status and Accounting Issues (open access)

POWs and MIAs: Status and Accounting Issues

None
Date: December 20, 2001
Creator: Goldich, Robert L.
Object Type: Report
System: The UNT Digital Library
Precipitates/Salts Model Calculations for Various Drift Temperature Environments (open access)

Precipitates/Salts Model Calculations for Various Drift Temperature Environments

The objective and scope of this calculation is to assist Performance Assessment Operations and the Engineered Barrier System (EBS) Department in modeling the geochemical effects of evaporation within a repository drift. This work is developed and documented using procedure AP-3.12Q, Calculations, in support of ''Technical Work Plan For Engineered Barrier System Department Modeling and Testing FY 02 Work Activities'' (BSC 2001a). The primary objective of this calculation is to predict the effects of evaporation on the abstracted water compositions established in ''EBS Incoming Water and Gas Composition Abstraction Calculations for Different Drift Temperature Environments'' (BSC 2001c). A secondary objective is to predict evaporation effects on observed Yucca Mountain waters for subsequent cement interaction calculations (BSC 2001d). The Precipitates/Salts model is documented in an Analysis/Model Report (AMR), ''In-Drift Precipitates/Salts Analysis'' (BSC 2001b).
Date: December 20, 2001
Creator: Marnier, P.
Object Type: Report
System: The UNT Digital Library
Precipitates/Salts Model Sensitivity Calculation (open access)

Precipitates/Salts Model Sensitivity Calculation

The objective and scope of this calculation is to assist Performance Assessment Operations and the Engineered Barrier System (EBS) Department in modeling the geochemical effects of evaporation on potential seepage waters within a potential repository drift. This work is developed and documented using procedure AP-3.12Q, ''Calculations'', in support of ''Technical Work Plan For Engineered Barrier System Department Modeling and Testing FY 02 Work Activities'' (BSC 2001a). The specific objective of this calculation is to examine the sensitivity and uncertainties of the Precipitates/Salts model. The Precipitates/Salts model is documented in an Analysis/Model Report (AMR), ''In-Drift Precipitates/Salts Analysis'' (BSC 2001b). The calculation in the current document examines the effects of starting water composition, mineral suppressions, and the fugacity of carbon dioxide (CO{sub 2}) on the chemical evolution of water in the drift.
Date: December 20, 2001
Creator: Mariner, P.
Object Type: Report
System: The UNT Digital Library
Proton radiation damage in high-resistivity n-type silicon CCDs (open access)

Proton radiation damage in high-resistivity n-type silicon CCDs

A new type of p-channel CCD constructed on high-resistivity n-type silicon was exposed to 12 MeV protons at doses up to 1x1011 protons/cm2. The charge transfer efficiency was measured as a function of radiation dose and temperature. We previously reported that these CCDs are significantly more tolerant to radiation damage than conventional n-channel devices. In the work reported here, we used pocket pumping techniques and charge transfer efficiency measurements to determine the identity and concentrations of radiation induced traps present in the damaged devices.
Date: December 20, 2001
Creator: Bebek, C. J.; Groom, D. E.; Holland, S. E.; Karcher, A.; Kolbe, W. F.; Lee, J. et al.
Object Type: Article
System: The UNT Digital Library
Radionuclide Transport Models Under Ambient Conditions (open access)

Radionuclide Transport Models Under Ambient Conditions

The purpose of Revision 00 of this Analysis/Model Report (AMR) is to evaluate (by means of 2-D semianalytical and 3-D numerical models) the transport of radioactive solutes and colloids in the unsaturated zone (UZ) under ambient conditions from the potential repository horizon to the water table at Yucca Mountain (YM), Nevada.
Date: December 20, 2001
Creator: Moridis, G. & Hu, Q.
Object Type: Report
System: The UNT Digital Library
Rio Grande Herald (Rio Grande City, Tex.), Vol. 88, No. 48, Ed. 1 Thursday, December 20, 2001 (open access)

Rio Grande Herald (Rio Grande City, Tex.), Vol. 88, No. 48, Ed. 1 Thursday, December 20, 2001

Weekly newspaper from Rio Grande City, Texas that includes local, state and national news along with extensive advertising.
Date: December 20, 2001
Creator: Roberts, Kenneth
Object Type: Newspaper
System: The Portal to Texas History