In this project we proposed to establish feasibility of the development of targeted tracers for radionuclide imaging of epidermal growth factor receptors (EGFR) in cancer patients. The significance and impact of the proposed radiotracers are determined by the crucial role that EGFR plays in many cancers and by the rapid entrance of EGFR-inhibiting drugs into clinic. Clinical experience, however, revealed that only 10-25% of patients that are defined as EGFR-positive by immunohistochemical analysis respond to EGFR-directed therapeutics and there is poor correlation between EGFR immunohistochemistry and treatment. Therefore, for more efficacious use of EGFR-targeting therapeutics, there is a need for information about EGFR activity in patients. We hypothesized that radionuclide imaging of functionally active EGFR will provide such information and would allow for 1) rational patient stratification, 2) rapid monitoring of responses to therapy, and 3) development of personalized treatment regimens. We hypothesized that tracers based epidermal growth factor (EGF), a natural EGFR ligand, as a targeting vector would be particularly advantageous. First, only functionally active and therefore critical for disease progression EGFRs will bind and internalize an EGF-based tracer. Second, continuous internalization of EGF-based tracers by recyclable EGFR would lead to intracellular accumulation of radionuclide and improved signal-to-background ratio. …

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This report is on Clinical Trials Reporting and Publication.

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Effluent streams from the Modular Caustic-Side Solvent Extraction Unit (MCU) will transfer to the tank farms and to the Defense Waste Processing Facility (DWPF). These streams will contain entrained solvent. A significant portion of the Strip Effluent (SE) pipeline (i.e., acid stream containing Isopar{reg_sign} L residues) length is within one inch of a sludge stream. Personnel envisioned the sludge stream temperature may reach 100 C during operation. The nearby SE stream may receive heat from the sludge stream and reach temperatures that may lead to flammability issues once the contents of the SE stream discharge into a larger reservoir. To this end, personnel used correlations from the literature to estimate the maximum temperature rise the SE stream may experience if the nearby sludge stream reaches boiling temperature. Several calculation methods were used to determine the temperature rise of the SE stream. One method considered a heat balance equation under steady state that employed correlation functions to estimate heat transfer rate. This method showed the maximum temperature of the acid stream (SE) may exceed 45 C when the nearby sludge stream is 80 C or higher. A second method used an effectiveness calculation used to predict the heat transfer rate in …

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A letter report issued by the Government Accountability Office with an abstract that begins "In 2005, federal spending on advertising exceeded $1 billion. Five agencies--DOD, Treasury, HHS, Interior, and NASA--together made up over 90 percent of this spending from 2001 to 2005. Executive Order 13170, signed in October 2000, directs agencies to take an aggressive role in ensuring substantial participation in federal advertising contracts by businesses in the Small Business Administration's (SBA) 8(a) and small disadvantaged business (SDB) programs and minority-owned businesses. This report describes (1) strategies DOD, HHS, Treasury, Interior, and NASA used to address Executive Order 13170, and (2) the total obligations, number of contract actions, and percentage of total obligations represented by these actions that each agency awarded to 8(a)s, SDBs, and minority-owned businesses for advertising services. In conducting this study, GAO analyzed agency contracting data and executive order implementation plans and interviewed agency procurement officials."

A letter report issued by the Government Accountability Office with an abstract that begins "Since the 1970s, the roles of women as both students and athletes have changed in higher education, with female enrollment surpassing male enrollment, and female athletic participation showing gains as well. These changes have generated public interest in whether women participate in athletics at comparable levels to men and whether men's opportunities have decreased as a result of the increased opportunities for women. Under the Comptroller General's authority, GAO assessed the extent to which the numbers of men's and women's intercollegiate sports teams and participants at 4-year colleges have changed from the 1991-1992 through 2004-2005 school years."

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This report details an overview of federal and state laws that regulate online pharmacies and physicians who prescribe drugs over the internet. Updated July 12, 2007.

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This report presents background on the development of TPA, a summary of the major provisions under the recently expired authority, and a discussion of the issues that have arisen in the debate over TPA renewal. It also explores the policy options available to Congress and will be updated as the congressional debate unfolds.

This report discusses broadband internet regulations. The goal is to ensure that broadband deployment is timely and contributes to nations to economic growth.

President Bush's Administration has advanced a "Charitable Choice" agenda aimed at expanding the ability of faith-based organizations to provide federally funded social services and encouraging states to do likewise. Charitable choice rules are intended to ensure that faith-based organizations participate more fully in federally funded social service programs and offer services without abandoning their religious character or infringing on the religious freedom of applicants and recipients.

This report provides information about the Background and Funding on Child Nutrition and WIC Programs. child nutrition programs provide free meals to lower-income children.The CACFP subsidies meals and snacks served by children.

U.S.-China economic ties have expanded substantially over the past several years. China is now the third largest U.S. trading partner, its second largest source of imports, and its fourth largest export market. However, U.S.-China commercial ties have been strained by a number of issues, including a surging U.S. trade deficit with China, China's refusal to float its currency, and failure to fully comply with its World Trade Organization (WTO) commitments, especially its failure to provide protection for U.S. intellectual property rights (IPR). This report explores these issues in detail, especially concerning the lack of protection for U.S. IPR.

U.S.-China economic ties have expanded substantially over the past several years. China is now the third largest U.S. trading partner, its second largest source of imports, and its fourth largest export market. However, U.S.-China commercial ties have been strained by a number of issues, including a surging U.S. trade deficit with China, China's refusal to float its currency, and failure to fully comply with its World Trade Organization (WTO) commitments, especially its failure to provide protection for U.S. intellectual property rights (IPR). This report explores these issues in detail, especially concerning the lack of protection for U.S. IPR.