Beam-beam interaction study of medium energy eRHIC (open access)

Beam-beam interaction study of medium energy eRHIC

Medium Energy eRHIC (MeRHIC), the first stage design of eRHIC, includes a multi-pass ERL that provides 4GeV high quality electron beam to collide with the ion beam of RHIC. It delivers a minimum luminosity of 10{sup 32} cm{sup -2}s{sup -1}. Beam-beam effects present one of major factors limiting the luminosity of colliders. In this paper, both beam-beam effects on the electron beam and the proton beam in MeRHIC are investigated. The beam-beam interaction can induce a head-tail type instability of the proton beam referred to as the kink instability. Thus, beam stability conditions should be established to avoid proton beam loss. Also, the electron beam transverse disruption by collisions has to be evaluated to ensure that the beam quality is good enough for the energy recovery pass. The relation of proton beam stability, electron disruption and consequential luminosity are carried out after thorough discussion.
Date: July 15, 2009
Creator: Hao,Y.; Litvinenko, V. N. & Ptitsyn, V.
System: The UNT Digital Library
Experimental Quenching of Harmonic Stimuli: Universality of Linear Response Theory (open access)

Experimental Quenching of Harmonic Stimuli: Universality of Linear Response Theory

This article discusses experimental quenching of harmonic stimuli.
Date: July 15, 2009
Creator: Allegrini, Paolo; Bologna, Mauro; Fronzoni, Leone; Grigolini, Paolo & Silvestri, Ludovico
System: The UNT Digital Library
Metagenome of a Versatile Chemolithoautotroph from Expanding Oceanic Dead Zones (open access)

Metagenome of a Versatile Chemolithoautotroph from Expanding Oceanic Dead Zones

Oxygen minimum zones (OMZs), also known as oceanic"dead zones", are widespread oceanographic features currently expanding due to global warming and coastal eutrophication. Although inhospitable to metazoan life, OMZs support a thriving but cryptic microbiota whose combined metabolic activity is intimately connected to nutrient and trace gas cycling within the global ocean. Here we report time-resolved metagenomic analyses of a ubiquitous and abundant but uncultivated OMZ microbe (SUP05) closely related to chemoautotrophic gill symbionts of deep-sea clams and mussels. The SUP05 metagenome harbors a versatile repertoire of genes mediating autotrophic carbon assimilation, sulfur-oxidation and nitrate respiration responsive to a wide range of water column redox states. Thus, SUP05 plays integral roles in shaping nutrient and energy flow within oxygen-deficient oceanic waters via carbon sequestration, sulfide detoxification and biological nitrogen loss with important implications for marine productivity and atmospheric greenhouse control.
Date: July 15, 2009
Creator: Walsh, David A.; Zaikova, Elena; Howes, Charles L.; Song, Young; Wright, Jody; Tringe, Susannah G. et al.
System: The UNT Digital Library
Occurrence of gas hydrate in Oligocene Frio sand: Alaminos Canyon Block 818: Northern Gulf of Mexico (open access)

Occurrence of gas hydrate in Oligocene Frio sand: Alaminos Canyon Block 818: Northern Gulf of Mexico

A unique set of high-quality downhole shallow subsurface well log data combined with industry standard 3D seismic data from the Alaminos Canyon area has enabled the first detailed description of a concentrated gas hydrate accumulation within sand in the Gulf of Mexico. The gas hydrate occurs within very fine grained, immature volcaniclastic sands of the Oligocene Frio sand. Analysis of well data acquired from the Alaminos Canyon Block 818 No.1 ('Tigershark') well shows a total gas hydrate occurrence 13 m thick, with inferred gas hydrate saturation as high as 80% of sediment pore space. Average porosity in the reservoir is estimated from log data at approximately 42%. Permeability in the absence of gas hydrates, as revealed from the analysis of core samples retrieved from the well, ranges from 600 to 1500 millidarcies. The 3-D seismic data reveals a strong reflector consistent with significant increase in acoustic velocities that correlates with the top of the gas-hydrate-bearing sand. This reflector extends across an area of approximately 0.8 km{sup 2} and delineates the minimal probable extent of the gas hydrate accumulation. The base of the inferred gas-hydrate zone also correlates well with a very strong seismic reflector that indicates transition into units of …
Date: July 15, 2009
Creator: Boswell, R.D.; Shelander, D.; Lee, M.; Latham, T.; Collett, T.; Guerin, G. et al.
System: The UNT Digital Library
Solid phase evolution in the Biosphere 2 hillslope experiment as predicted by modeling of hydrologic and geochemical fluxes (open access)

Solid phase evolution in the Biosphere 2 hillslope experiment as predicted by modeling of hydrologic and geochemical fluxes

A reactive transport geochemical modeling study was conducted to help predict the mineral transformations occurring over a ten year time-scale that are expected to impact soil hydraulic properties in the Biosphere 2 (B2) synthetic hillslope experiment. The modeling sought to predict the rate and extent of weathering of a granular basalt (selected for hillslope construction) as a function of climatic drivers, and to assess the feedback effects of such weathering processes on the hydraulic properties of the hillslope. Flow vectors were imported from HYDRUS into a reactive transport code, CrunchFlow2007, which was then used to model mineral weathering coupled to reactive solute transport. Associated particle size evolution was translated into changes in saturated hydraulic conductivity using Rosetta software. We found that flow characteristics, including velocity and saturation, strongly influenced the predicted extent of incongruent mineral weathering and neo-phase precipitation on the hillslope. Results were also highly sensitive to specific surface areas of the soil media, consistent with surface reaction controls on dissolution. Effects of fluid flow on weathering resulted in significant differences in the prediction of soil particle size distributions, which should feedback to alter hillslope hydraulic conductivities.
Date: July 15, 2009
Creator: Dontsova, K.; Steefel, C.I.; Desilets, S.; Thompson, A. & Chorover, J.
System: The UNT Digital Library
Wind Power Price Trends in the United States (open access)

Wind Power Price Trends in the United States

For the fourth year in a row, the United States led the world in adding new wind power capacity in 2008, and also surpassed Germany to take the lead in terms of cumulative installed wind capacity. The rapid growth of wind power in the U.S. over the past decade (Figure 1) has been driven by a combination of increasingly supportive policies (including the Federal production tax credit (PTC) and a growing number of state renewables portfolio standards), uncertainty over the future fuel costs and environmental liabilities of natural gas and coal-fired power plants, and wind's competitive position among generation resources. This article focuses on just the last of these drivers - i.e., trends in U.S. wind power prices - over the period of strong capacity growth since 1998.
Date: July 15, 2009
Creator: Bolinger, Mark & Wiser, Ryan
System: The UNT Digital Library
Characterization of Surplus Plutonium for Disposition Options (open access)

Characterization of Surplus Plutonium for Disposition Options

The United States (U.S.) has identified 61.5 metric tons (MT) of plutonium that is permanently excess to use in nuclear weapons programs, including 47.2 MT of weapons-grade plutonium. Except for materials that remain in use for programs outside of national defense, including programs for nuclear-energy development, the surplus inventories will be stored safely by the Department of Energy (DOE) and then transferred to facilities that will prepare the plutonium for permanent disposition. Some items will be disposed as transuranic waste, low-level waste, or spent fuel. The remaining surplus plutonium will be managed through: (1) the Mixed Oxide (MOX) Fuel Fabrication Facility (FFF), to be constructed at the Savannah River Site (SRS), where the plutonium will be converted to fuel that will be irradiated in civilian power reactors and later disposed to a high-level waste (HLW) repository as spent fuel; (2) the SRS H-Area facilities, by dissolving and transfer to HLW systems, also for disposal to the repository; or (3) alternative immobilization techniques that would provide durable and secure disposal. From the beginning of the U.S. program for surplus plutonium disposition, DOE has sponsored research to characterize the surplus materials and to judge their suitability for planned disposition options. Because many …
Date: July 15, 2008
Creator: Allender, Jeffrey S.; Moore, Edwin N. & Davies, Scott H.
System: The UNT Digital Library
Gravity monitoring of CO2 movement during sequestration: Model studies (open access)

Gravity monitoring of CO2 movement during sequestration: Model studies

We examine the relative merits of gravity measurements as a monitoring tool for geological CO{sub 2} sequestration in three different modeling scenarios. The first is a combined CO{sub 2} enhanced oil recovery (EOR) and sequestration in a producing oil field, the second is sequestration in a brine formation, and the third is for a coalbed methane formation. EOR/sequestration petroleum reservoirs have relatively thin injection intervals with multiple fluid components (oil, hydrocarbon gas, brine, and CO{sub 2}), whereas brine formations usually have much thicker injection intervals and only two components (brine and CO{sub 2}). Coal formations undergoing methane extraction tend to be thin (3-10 m), but shallow compared to either EOR or brine formations. The injection of CO{sub 2} into the oil reservoir produced a bulk density decrease in the reservoir. The spatial pattern of the change in the vertical component of gravity (G{sub z}) is directly correlated with the net change in reservoir density. Furthermore, time-lapse changes in the borehole G{sub z} clearly identified the vertical section of the reservoir where fluid saturations are changing. The CO{sub 2}-brine front, on the order of 1 km within a 20 m thick brine formation at 1900 m depth, with 30% CO{sub 2} …
Date: July 15, 2008
Creator: Gasperikova, E. & Hoversten, G.M.
System: The UNT Digital Library
An Implicit "Drift-Lorentz" Particle Mover for Plasma and Beam Simulations (open access)

An Implicit "Drift-Lorentz" Particle Mover for Plasma and Beam Simulations

In order to efficiently perform particle simulations in systems with widely varying magnetization, we developed a drift-Lorentz mover, which interpolates between full particle dynamics and drift kinetics in such a way as to preserve a physically correct gyroradius and particle drifts for both large and small ratios of the timestep to the cyclotron period. In order to extend applicability of the mover to systems with plasma frequency exceeding the cyclotron frequency such as one may have with fully neutralized drift compression of a heavy-ion beam we have developed an implicit version of the mover. A first step in this direction, in which the polarization charge was added to the field solver, was described previously. Here we describe a fully implicit algorithm (which is analogous to the direct-implicit method for conventionalparticle-in-cell simulation), summarize a stability analysis of it, and describe several tests of the resultant code.
Date: July 15, 2008
Creator: Friedman, A.; Grote, D. P.; Vay, J. L. & Cohen, R. H.
System: The UNT Digital Library
Molybdenum and Tungsten Structural Differences are Dependent on ndz2/(n + 1)ѕ Mixing: Comparisons of (silox)3MX/R (M = Mo, W; silox = tBu3SiO) (open access)

Molybdenum and Tungsten Structural Differences are Dependent on ndz2/(n + 1)ѕ Mixing: Comparisons of (silox)3MX/R (M = Mo, W; silox = tBu3SiO)

Article discussing molybdenum and tungsten structural differences being dependent on ndz2/(n + 1)s mixing and a comparison of (silox)3MX/R (M = Mo, W; silox - tBu3SiO).
Date: July 15, 2008
Creator: Kuiper, David S.; Douthwalte, Richard E.; Mayoi, Ana-Rita; Wolczanski, Peter T.; Lobkovsky, Emil B.; Cundari, Thomas R., 1964- et al.
System: The UNT Digital Library
The passivation of calcite by acid mine water. Column experiments with Fe(III)-SO4-H+ and Fe(III)-Cl-H+ solutions at pH 2 (open access)

The passivation of calcite by acid mine water. Column experiments with Fe(III)-SO4-H+ and Fe(III)-Cl-H+ solutions at pH 2

None
Date: July 15, 2008
Creator: Soler, Josep M.; Boi, Marco; Mogollon, Jose Luis; Cama, Jordi; Ayora, Carlos; Nico, Peter S. et al.
System: The UNT Digital Library
Protein-Nanocrystal Conjugates Support a Single Filament Polymerization Model in R1 Plasmid Segregation (open access)

Protein-Nanocrystal Conjugates Support a Single Filament Polymerization Model in R1 Plasmid Segregation

To ensure inheritance by daughter cells, many low-copy number bacterial plasmids, including the R1 drug-resistance plasmid, encode their own DNA segregation systems. The par operon of plasmid R1 directs construction of a simple spindle structure that converts free energy of polymerization of an actin-like protein, ParM, into work required to move sister plasmids to opposite poles of rod-shaped cells. The structures of individual components have been solved, but little is known about the ultrastructure of the R1 spindle. To determine the number of ParM filaments in a minimal R1 spindle, we used DNA-gold nanocrystal conjugates as mimics of the R1 plasmid. Wefound that each end of a single polar ParM filament binds to a single ParR/parC-gold complex, consistent with the idea that ParM filaments bind in the hollow core of the ParR/parC ring complex. Our results further suggest that multifilament spindles observed in vivo are associated with clusters of plasmidssegregating as a unit.
Date: July 15, 2008
Creator: Choi, Charina L.; Claridge, Shelley A.; Garner, Ethan C.; Alivisatos, A. Paul & Mullins, R. Dyche
System: The UNT Digital Library
A Semi-Analytical Solution for Large-Scale Injection-Induced PressurePerturbation and Leakage in a Laterally Bounded Aquifer-AquitardSystem (open access)

A Semi-Analytical Solution for Large-Scale Injection-Induced PressurePerturbation and Leakage in a Laterally Bounded Aquifer-AquitardSystem

A number of (semi-)analytical solutions are available to drawdown analysis and leakage estimation of shallow aquifer-aquitard systems. These solutions assume that the systems are laterally infinite. When a large-scale pumping from (or injection into) an aquifer-aquitard system of lower specific storativity occurs, induced pressure perturbation (or hydraulic head drawdown/rise) may reach the lateral boundary of the aquifer. We developed semi-analytical solutions to address the induced pressure perturbation and vertical leakage in a 'laterally bounded' system consisting of an aquifer and an overlying/underlying aquitard. A one-dimensional radial flow equation for the aquifer was coupled with a one-dimensional vertical flow equation for the aquitard, with a no-flow condition imposed on the outer radial boundary. Analytical solutions were obtained for (1) the Laplace-transform hydraulic head drawdown/rise in the aquifer and in the aquitard, (2) the Laplace-transform rate and volume of leakage through the aquifer-aquitard interface integrated up to an arbitrary radial distance, (3) the transformed total leakage rate and volume for the entire interface, and (4) the transformed horizontal flux at any radius. The total leakage rate and volume depend only on the hydrogeologic properties and thicknesses of the aquifer and aquitard, as well as the duration of pumping or injection. It was …
Date: July 15, 2008
Creator: Zhou, Quanlin; Birkholzer, Jens T. & Tsang, Chin-Fu
System: The UNT Digital Library
State Policies Provide Critical Support for Renewable Electricity (open access)

State Policies Provide Critical Support for Renewable Electricity

Growth in renewable energy in the U.S. over the past decade has been propelled by a number of forces, including rising fossil fuel prices, environmental concerns, and policy support at the state and federal levels. In this article, we review and discuss what are arguably the two most important types of state policies for supporting electricity generation from geothermal and other forms of renewable energy: renewables portfolio standards and utility integrated resource planning requirements. Within the Western U.S., where the vast majority of the nation's readily-accessible geothermal resource potential resides, these two types of state policies have been critical to the growth of renewable energy, and both promise to continue to play a fundamental role for the foreseeable future. In its essence, a renewables portfolio standard (RPS) requires utilities and other retail electricity suppliers to produce or purchase a minimum quantity or percentage of their generation supply from renewable resources. RPS purchase obligations generally increase over time, and retail suppliers typically must demonstrate compliance on an annual basis. Mandatory RPS policies are backed by various types of compliance enforcement mechanisms, although most states have incorporated some type of cost-containment provision, such as a cost cap or a cap on retail …
Date: July 15, 2008
Creator: Barbose, Galen; Wiser, Ryan & Bolinger, Mark
System: The UNT Digital Library
A study of vacuum arc ion velocities using a linear set of probes (open access)

A study of vacuum arc ion velocities using a linear set of probes

The most likely velocity of ions moving away from vacuum arc cathode spots was measured using a set of probes along the path of plasma expansion. The goal was to determine how much, if any, change of the ion drift velocity occurs in the expanded plasma. The arc discharge current was perturbed to create plasma density markers whose travel is picked up by the set of probes. It was found that the perturbation with current oscillations did not result in consistent data because ion current maxima and minima are not only determined by the plasma production but by the transients of the arc pulse and by the asymmetry of the ion velocity distribution function. Perturbation with a short current spike was more conclusive. The ion velocity was measured to be slightly reduced with increasing distance from the cathode, which can be explained by collisions of ions with the background of neutrals. The ion velocity was increased when the arc current was increased, which correlated with enhanced arc voltage and power dissipation. The ion velocity could be enhanced when the plasma was produced in a non-uniform magnetic field.
Date: July 15, 2008
Creator: Hohenbild, Stefan; Grubel, Christoph; Yushkov, Georgy Yu.; Oks, Efim M. & Anders, Andre
System: The UNT Digital Library
Surpassing Expectations: State of the U.S. Wind Power Market (open access)

Surpassing Expectations: State of the U.S. Wind Power Market

The wind power industry in the U.S. has been on a growth binge in recent years, and the rapid pace of development has made it difficult to keep up with trends in the marketplace. Yet the need for timely, objective information on the wind industry and its progress has never been greater. This article, excerpted from a longer report from the U.S. Department of Energy, attempts to fill this need by providing a comprehensive, yet detailed, overview of key developments in the U.S. wind power market, with a particular focus on 2007. This summary includes information on wind project installation trends, industry developments, and, perhaps most interestingly, project-level installed cost and pricing information that has not otherwise been widely reported. The article concentrates on larger-scale wind applications, defined here as projects utilizing turbines that exceed 50 kW in size. In many cases, the data reported here represent only a sample of all wind projects installed in the United States; furthermore, the data vary in quality. As such, emphasis should be placed on overall trends in the data, rather than on individual data points.
Date: July 15, 2008
Creator: Bolinger, Mark A. & Wiser, Ryan
System: The UNT Digital Library
Trends in on-Road Vehicle Emissions of Ammonia (open access)

Trends in on-Road Vehicle Emissions of Ammonia

Motor vehicle emissions of ammonia have been measured at a California highway tunnel in the San Francisco Bay area. Between 1999 and 2006, light-duty vehicle ammonia emissions decreased by 38 {+-} 6%, from 640 {+-} 40 to 400 {+-} 20 mg kg{sup -1}. High time resolution measurements of ammonia made in summer 2001 at the same location indicate a minimum in ammonia emissions correlated with slower-speed driving conditions. Variations in ammonia emission rates track changes in carbon monoxide more closely than changes in nitrogen oxides, especially during later evening hours when traffic speeds are highest. Analysis of remote sensing data of Burgard et al. (Environ Sci. Technol. 2006, 40, 7018-7022) indicates relationships between ammonia and vehicle model year, nitrogen oxides, and carbon monoxide. Ammonia emission rates from diesel trucks were difficult to measure in the tunnel setting due to the large contribution to ammonia concentrations in a mixed-traffic bore that were assigned to light-duty vehicle emissions. Nevertheless, it is clear that heavy-duty diesel trucks are a minor source of ammonia emissions compared to light-duty gasoline vehicles.
Date: July 15, 2008
Creator: Kean, A. J.; Littlejohn, D.; Ban-Weiss, G. A.; Harley, R. A.; Kirchstetter, T. W. & Lunden, M. M.
System: The UNT Digital Library
Using 3-D Modeling to Improve the Efficiency for Removing Plutonium Processing Equiment From Gloveboxes at the Plutonium Finishang Plant (open access)

Using 3-D Modeling to Improve the Efficiency for Removing Plutonium Processing Equiment From Gloveboxes at the Plutonium Finishang Plant

The Plutonium Finishing Plant at the Department of Energy's Hanford Site in southeastern Washington State began operations in 1949 to process plutonium and plutonium products. Its primary mission was to produce plutonium metal, fabricate weapons parts, and stabilize reactive materials. These operations, and subsequent activities, were performed in production lines, consisting primarily of hundreds of gloveboxes. Over the years, these gloveboxes and attendant processes have been continuously modified. The plant is currently inactive and Fluor Hanford has been tasked with cleaning out contaminated equipment and gloveboxes from the facility so it can be demolished in the near future. Approximately 100 gloveboxes at PFP have been cleaned out in the past four years and about 90 gloveboxes remain to be cleaned out. Because specific commitment dates for this work have been established with the State of Washington and other entities, it is important to adopt work practices that increase the safety and speed of this effort. The most recent work practice to be adopted by Fluor Hanford D and D workers is the use of 3-D models to make the process of cleaning out the radioactive gloveboxes more efficient. The use of 3-D models has significantly improved the work-planning process by …
Date: July 15, 2008
Creator: Crow, S. H.; Kyle, R. N. & Minette, M. J.
System: The UNT Digital Library
UXO detection and identification based on intrinsic target polarizabilities: A case history (open access)

UXO detection and identification based on intrinsic target polarizabilities: A case history

Electromagnetic induction data parameterized in time dependent object intrinsic polarizabilities allow discrimination of unexploded ordnance (UXO) from false targets (scrap metal). Data from a cart-mounted system designed for discrimination of UXO with 20 mm to 155 mm diameters are used. Discrimination of UXO from irregular scrap metal is based on the principal dipole polarizabilities of a target. A near-intact UXO displays a single major polarizability coincident with the long axis of the object and two equal smaller transverse polarizabilities, whereas metal scraps have distinct polarizability signatures that rarely mimic those of elongated symmetric bodies. Based on a training data set of known targets, object identification was made by estimating the probability that an object is a single UXO. Our test survey took place on a military base where both 4.2-inch mortar shells and scrap metal were present. The results show that we detected and discriminated correctly all 4.2-inch mortars, and in that process we added 7%, and 17%, respectively, of dry holes (digging scrap) to the total number of excavations in two different survey modes. We also demonstrated a mode of operation that might be more cost effective than the current practice.
Date: July 15, 2008
Creator: Gasperikova, E.; Smith, J.T.; Morrison, H.F.; Becker, A. & Kappler, K.
System: The UNT Digital Library
Deletion of ultraconserved elements yields viable mice (open access)

Deletion of ultraconserved elements yields viable mice

Ultraconserved elements have been suggested to retainextended perfect sequence identity between the human, mouse, and ratgenomes due to essential functional properties. To investigate thenecessities of these elements in vivo, we removed four non-codingultraconserved elements (ranging in length from 222 to 731 base pairs)from the mouse genome. To maximize the likelihood of observing aphenotype, we chose to delete elements that function as enhancers in amouse transgenic assay and that are near genes that exhibit markedphenotypes both when completely inactivated in the mouse as well as whentheir expression is altered due to other genomic modifications.Remarkably, all four resulting lines of mice lacking these ultraconservedelements were viable and fertile, and failed to reveal any criticalabnormalities when assayed for a variety of phenotypes including growth,longevity, pathology and metabolism. In addition more targeted screens,informed by the abnormalities observed in mice where genes in proximityto the investigated elements had been altered, also failed to revealnotable abnormalities. These results, while not inclusive of all thepossible phenotypic impact of the deleted sequences, indicate thatextreme sequence constraint does not necessarily reflect crucialfunctions required for viability.
Date: July 15, 2007
Creator: Ahituv, Nadav; Zhu, Yiwen; Visel, Axel; Holt, Amy; Afzal, Veena; Pennacchio, Len A. et al.
System: The UNT Digital Library
Atomistic mechanism of shock-induced void collapse in nano-porous metals (open access)

Atomistic mechanism of shock-induced void collapse in nano-porous metals

We have investigated the microstructural changes in ductile porous metals during high pressure-high strain rate loading employing atomistic simulations and explored their relation to recent experiments on polycrystalline copper samples. Molecular-dynamics simulations of shocks in porous, single crystal samples show the formation of nano-grains due to localized massive plastic deformation induced by the presence of voids. In the process of grain formation the individual voids serve as dislocation sources. The efficiency of these sources is further enhanced by their collective interaction which eventually leads to very high dislocation densities. In agreement with experimental studies, the simulations display a temporal delay of the particle velocity in comparison to perfectly crystalline samples. This delay increases with porosity. Our results point towards the importance of void-void interactions and collective effects during dynamic loading of porous materials.
Date: July 15, 2005
Creator: Erhart, P; Bringa, E; Kumar, M & Albe, K
System: The UNT Digital Library
Design Principles for the Use of Electroactive Polymers forOvercharge Protection of Lithium-Ion Batteries (open access)

Design Principles for the Use of Electroactive Polymers forOvercharge Protection of Lithium-Ion Batteries

None
Date: July 15, 2005
Creator: Thomas-Alyea, Karen E.; Newman, John; Chen, Guoying & Richardson,Thomas J.
System: The UNT Digital Library
ETOPOSIDE INDUCES CHROMOSOMAL ABNORMALITIES IN SPERMATOCYTES AND SPERMATOGONIAL STEM CELLS (open access)

ETOPOSIDE INDUCES CHROMOSOMAL ABNORMALITIES IN SPERMATOCYTES AND SPERMATOGONIAL STEM CELLS

Etoposide (ET) is a chemotherapeutic agent widely used in the treatment of leukemia, lymphomas and many solid tumors, such as testicular and ovarian cancers, that affect patients in their reproductive years. The purpose of the study was to use sperm FISH analyses to characterize the long-term effects of ET on male germ cells. We used a mouse model to characterize the induction of chromosomal aberrations (partial duplications and deletions) and whole chromosomal aneuploidies in sperm of mice treated with a clinical dose of ET. Semen samples were collected at 25 and 49 days after dosing to investigate the effects of ET on meiotic pachytene cells and spermatogonial stem-cells, respectively. ET treatment resulted in major increases in the frequencies of sperm carrying chromosomal aberrations in both meiotic pachytene (27- to 578-fold) and spermatogonial stem-cells (8- to 16-fold), but aneuploid sperm were induced only after treatment of meiotic cells (27-fold) with no persistent effects in stem cells. These results demonstrate that male meiotic germ cells are considerably more sensitive to ET than spermatogonial stem-cell and that increased frequencies of sperm with structural aberrations persist after spermatogonial stem-cell treatment. These findings predict that patients who undergo chemotherapy with ET may have transient elevations …
Date: July 15, 2005
Creator: Marchetti, F; Pearson, F S; Bishop, J B & Wyrobek, A J
System: The UNT Digital Library
Evidence for back scattering of near-podal seismic P'P' waves from the 150-220 km zone in Earth's upper mantle (open access)

Evidence for back scattering of near-podal seismic P'P' waves from the 150-220 km zone in Earth's upper mantle

The deepest and most inaccessible parts of Earth's interior--the core and core-mantle boundary regions can be studied from compressional waves that turn in the core and are routinely observed following large earthquakes at epicentral distances between 145{sup o} and 180{sup o} (also called P', PKIKP or PKP waves). P'P' (PKPPKP) are P' waves that travel from a hypocenter through the Earth's core, reflect from the free surface and travel back through the core to a recording station on the surface. P'P' waves are sometimes accompanied by precursors, which were reported first in the 1960s as small-amplitude arrivals on seismograms at epicentral distances of about 50{sup o}-70{sup o}. Most prominent of these observed precursors were explained by P'P' waves generated by earthquakes or explosions that did not reach the Earth's surface but were reflected from the underside of first order velocity discontinuities at 410 and 660 km in the upper mantle mantle. Here we report the discovery of hitherto unobserved near-podal P'P' waves (at epicentral distance less than 10{sup o}) and very prominent precursors preceding the main energy by as much as 55 seconds. We interpret these precursors as a back scattered energy from undocumented structure in the upper mantle, in …
Date: July 15, 2005
Creator: Tkalcic, H; Flanagan, M P & Cormier, V F
System: The UNT Digital Library