A letter report issued by the Government Accountability Office with an abstract that begins "The President's Emergency Plan for AIDS Relief (PEPFAR) provides assistance for combating HIV/AIDS in 15 focus countries and elsewhere, with global targets for prevention, treatment, and care. The U.S. Leadership Against HIV/AIDS, TB and Malaria Act of 2003, which authorizes the $15 billion program, contains directives to guide the Office of the U.S. Global AIDS Coordinator's (OGAC) allocation of this funding. The act expires in September 2008. The President announced his intention to ask Congress to authorize $30 billion for these efforts for the next 5 years. In 2007, the Institute of Medicine (IOM) recommended eliminating the directives. GAO was asked to describe (1) the views of HIV/AIDS experts on these directives, (2) an alternative approach to allocating funds, and (3) potential challenges related to this approach. GAO interviewed 22 experts, surveyed PEPFAR officials in the 15 focus countries, and reviewed pertinent documentation."

Testimony issued by the Government Accountability Office with an abstract that begins "Because advisory committees provide input to federal decision makers on significant national issues, it is essential that their membership be, and be perceived as being, free from conflicts of interest and balanced as a whole. The Federal Advisory Committee Act (FACA) was enacted in 1972, in part, because of concerns that special interests had too much influence over federal agency decision makers. The General Services Administration (GSA) develops guidance on establishing and managing FACA committees. The Office of Government Ethics (OGE) develops regulations and guidance for statutory conflict-of- interest provisions that apply to some advisory committee members. As requested, this testimony discusses key findings and conclusions in our 2004 report, Federal Advisory Committees: Additional Guidance Could Help Agencies Better Ensure Independence and Balance; GAO's recommendations to GSA and OGE and their responses; and potential changes to FACA that could better ensure the independence and balance of advisory committees. For our 2004 work, we reviewed policies and procedures issued by GSA, OGE, and nine federal agencies that sponsor many committees. For this testimony, we obtained information from GSA and OGE on actions they have taken to implement our recommendations; …

Other written product issued by the Government Accountability Office with an abstract that begins "This is the E-supplement to GAO-08-480. This document presents the results of our electronic survey of 41 U.S. officials implementing PEPFAR funding in 15 focus countries (country team officials). We conducted the survey to identify potential challenges to implementing an alternative approach, developed from HIV/AIDS experts' suggestions, to allocating funds for the next 5-year phase of PEPFAR. The survey respondents included the Centers for Disease Control and Prevention (CDC) Chief of Party, the U.S. Agency for International Development (USAID) health team leader, and the PEPFAR coordinator in each of the 15 focus countries. The questions in our survey were intended to obtain information on country teams' experiences with setting targets, selecting interventions, and using cost information. Of the 41 country team officials, 38 responded to the survey, resulting in a survey response rate of 93 percent. This document presents results from all closed-ended survey questions but does not include narrative responses that we received. A more detailed discussion of our scope and methodology is contained in our report Global HIV/AIDS: A More Country-Based Approach Could Improve Allocation of PEPFAR Funding (GAO-08-480). We administered the survey from …

Correspondence issued by the Government Accountability Office with an abstract that begins "The Department of Defense (DOD) relies on a global network of critical physical and cyber infrastructure to project, support, and sustain its forces and operations worldwide. The incapacitation, exploitation, or destruction of one or more of its assets would seriously damage DOD's ability to carry out its core missions. To identify and help assure the availability of this mission-critical infrastructure, in August 2005, DOD established the Defense Critical Infrastructure Program (DCIP), assigning overall responsibility for the program to the Assistant Secretary of Defense for Homeland Defense and Americas' Security Affairs (ASD[HD&ASA]). Since 2006, ASD(HD&ASA) has collaborated with the Joint Staff to compile a list of all DOD- and non-DOD-owned infrastructure essential to accomplish the National Defense Strategy. Each critical asset on the list must undergo a vulnerability assessment, which identifies weaknesses in relation to potential threats and suggests options to address those weaknesses. Data and material designated as Sensitive Compartmented Information (SCI) or associated with Special Access Programs (SAP) are among the nation's most valued and closely guarded assets, and DOD faces inherent challenges in incorporating them into DCIP. The number of individuals authorized to access SCI and …

Presentation prepared for the 2008 National Hydrogen Association Conference that describes the spring 2008 results for DOE's Fuel Cell Vehicle Learning Demonstration.

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The gallium-stabilized Pu-2.0 at. % Ga alloy undergoes a partial or incomplete low-temperature martensitic transformation from the metastable {delta} phase to the gallium-containing, monoclinic {alpha}{prime} phase near -100 C. This transformation has been shown to occur isothermally and it displays anomalous double-C kinetics in a time-temperature-transformation (TTT) diagram, where two nose temperatures anchoring an upper- and lower-C describe minima in the time for the initiation of transformation. The underlying mechanisms responsible for the double-C behavior are currently unresolved, although recent experiments suggest that a conditioning treatment--wherein, following an anneal at 375 C, the sample is held at a sub-anneal temperature for a period of time--significantly influences the upper-C of the TTT diagram. As such, elucidating the effects of the conditioning treatment upon the {delta} {yields} {alpha}{prime} transformation can provide valuable insights into the fundamental mechanisms governing the double-C kinetics of the transition. Following a high-temperature anneal, a differential scanning calorimeter (DSC) was used to establish an optimal conditioning curve that depicts the amount of {alpha}{prime} formed during the transformation as a function of conditioning temperature for a specified time. With the optimal conditioning curve as a baseline, the DSC was used to explore the circumstances under which the effects of …

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We demonstrate a preparative method which produces highly-monodisperse Pt-nanoparticles of tunable size without the external addition of seed particles. Hexachloroplatinic acid is dosed slowly to an ethylene glycol solution at 120 C and reduced in the presence of a stabilizing polymer poly-N-vinylpyrollidone (PVP). Slow addition of the Pt-salt first will first lead to the formation of nuclei (seeds) which then grow further to produce larger particles of any desired size between 3 and 8nm. The amount of added hexachloroplatinic acid precursor controls the size of the final nanoparticle product. TEM was used to determine size and morphology and to confirm the crystalline nature of the nanoparticles. Good reproducibility of the technique was demonstrated. Above 7nm, the particle shape and morphology changes suddenly indicating a change in the deposition selectivity of the Pt-precursor from (100) towards (111) crystal faces and breaking up of larger particles into smaller entities.

Energy-dependent quenching of excess absorbed light energy (qE) is a vital mechanism for regulating photosynthetic light harvesting in higher plants. All of the physiological characteristics of qE have been positively correlated with charge-transfer between coupled chlorophyll and zeaxanthin molecules in the light-harvesting antenna of photosystem II (PSII). In this work, we present evidence for charge-transfer quenching in all three of the individual minor antenna complexes of PSII (CP29, CP26, and CP24), and we conclude that charge-transfer quenching in CP29 involves a de-localized state of an excitonically coupled chlorophyll dimer. We propose that reversible conformational changes in CP29 can `tune? the electronic coupling between the chlorophylls in this dimer, thereby modulating the energy of the chlorophylls-zeaxanthin charge-transfer state and switching on and off the charge-transfer quenching during qE.

A detailed chemical kinetic model is used to explore the flammability and detonability of hydrogen mixtures. In the case of flammability, a detailed chemical kinetic mechanism for hydrogen is coupled to the CHEMKIN Premix code to compute premixed, laminar flame speeds. The detailed chemical kinetic model reproduces flame speeds in the literature over a range of equivalence ratios, pressures and reactant temperatures. A series of calculation were performed to assess the key parameters determining the flammability of hydrogen mixtures. Increased reactant temperature was found to greatly increase the flame speed and the flammability of the mixture. The effect of added diluents was assessed. Addition of water and carbon dioxide were found to reduce the flame speed and thus the flammability of a hydrogen mixture approximately equally well and much more than the addition of nitrogen. The detailed chemical kinetic model was used to explore the detonability of hydrogen mixtures. A Zeldovich-von Neumann-Doring (ZND) detonation model coupled with detailed chemical kinetics was used to model the detonation. The effectiveness on different diluents was assessed in reducing the detonability of a hydrogen mixture. Carbon dioxide was found to be most effective in reducing the detonability followed by water and nitrogen. The chemical …

The cooling channel of the Muon Ionization Cooling Experiment (MICE) consists of eighteen superconducting solenoid coils, which are magnetically hooked together and contained in seven modules. The operations of a pair of MICE superconducting coupling magnets are affected directly by the other solenoid coils in the MICE channel. In order to meet the stringent requirement for the magnet center and axis azimuthal angle at 4.2 K, a self-centered tension-band cold mass support system with intermediate thermal interruption was applied for the MICE superconducting coupling magnet. The physical center of the magnet does not change as it is cooled down from 300 K to 4.2 K using this support system. This paper analyzed and calculated force loads on the coupling magnet under various operation modes of the MICE cooling channel. The performance parameters of a single-band cold mass support system were calculated also.

We report first light from a novel, new source of 10-ps 0.776-MeV gamma-ray pulses known as T-REX (Thomson-Radiated Extreme X-rays). The MeV-class radiation produced by TREX is unique in the world with respect to its brightness, spectral purity, tunability, pulse duration and laser-like beam character. With T-REX, one can use photons to efficiently probe and excite the isotope-dependent resonant structure of atomic nucleus. This ability will be enabling to an entirely new class of isotope-specific, high resolution imaging and detection capabilities.

This document summarizes the performance of the groundwater restoration systems installed by the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) at the former CCC/USDA grain storage facility in Utica, Nebraska, during the third year of system operation, from December 1, 2006, until November 30, 2007. In the project at Utica, the CCC/USDA is cooperating with multiple state and federal agencies to remove carbon tetrachloride contamination from a shallow aquifer underlying the town and to provide supplemental treated groundwater for use in the restoration of a nearby wetlands area. Argonne National Laboratory has assisted the CCC/USDA by providing technical oversight for the aquifer restoration effort and facilities during this review period. This document presents overviews of the aquifer restoration facilities (Section 2) and system operations (Section 3), then describes groundwater production results (Section 4); groundwater treatment results (Section 5); and associated groundwater monitoring, system modifications, and costs during the review period (Section 6). Section 7 summarizes the present year of operation and provides some comparisons with system performance in previous years. The performance of the groundwater restoration systems at Utica in earlier years was summarized in greater detail previously (Argonne 2005, 2006).

Electrolysis of water, particularly in conjunction with renewable energy sources, is potentially a cost-effective and environmentally friendly method of producing hydrogen at dispersed forecourt sites, such as automotive fueling stations. The primary feedstock for an electrolyzer is electricity, which could be produced by renewable sources such as wind or solar that do not produce carbon dioxide or other greenhouse gas emissions. However, state-of-the-art electrolyzer systems are not economically competitive for forecourt hydrogen production due to their high capital and operating costs, particularly the cost of the electricity used by the electrolyzer stack. In this project, Giner Electrochemical Systems, LLC (GES) developed a low cost, high efficiency proton-exchange membrane (PEM) electrolysis system for hydrogen production at moderate pressure (300 to 400 psig). The electrolyzer stack operates at differential pressure, with hydrogen produced at moderate pressure while oxygen is evolved at near-atmospheric pressure, reducing the cost of the water feed and oxygen handling subsystems. The project included basic research on catalysts and membranes to improve the efficiency of the electrolysis reaction as well as development of advanced materials and component fabrication methods to reduce the capital cost of the electrolyzer stack and system. The project culminated in delivery of a prototype electrolyzer …

A pair of superconducting coupling magnets will be part of the Muon Ionization Cooling Experiment (MICE). They were designed and will be constructed by the Institute of Cryogenics and Superconductivity Technology, Harbin Institute of Technology, in collaboration with Lawrence Berkeley National Laboratory. The coupling magnet is to be cooled by using cryocoolers at 4.2K. In order to reduce the heat leak to the 4.2K cold mass from 300 K, a pair of current leads composed of conventional copper leads and high temperature superconductor (HTS) leads will be used to supply current to the magnet. This paper presents the optimization of the conventional conduction-cooled metal leads for the coupling magnet. Analyses on heat transfer down the leads using theoretical method and numerical simulation were carried out. The stray magnetic field around the HTS leads has been calculated and effects of the magnetic field on the performance of the HTS leads has also been analyzed.

Polo-like kinase 1, PLK1, has important functions in maintaining genome stability and is involved in regulation of mitosis. PLK1 is up regulated in many invasive carcinomas. We asked whether it may also play a role in acquisition of invasiveness, a crucial step in transition to malignancy. In a model of metaplastic basal-like breast carcinoma progression, we found that PLK1 expression is necessary but not sufficient to induce invasiveness through laminin-rich extracellular matrix. PLK1 mediates invasion via Vimentin and {beta}1 integrin, both of which are necessary. We observed that PLK1 phosphorylates Vimentin on serine 82, which in turn regulates cell surface levels of {beta}1 integrin. We found PLK1 to be also highly expressed in pre-invasive in situ carcinomas of the breast. These results support a role for the involvement of PLK1 in the invasion process and point to this pathway as a potential therapeutic target for pre-invasive and invasive breast carcinoma treatment.

Free weekly newspaper that includes business and classified advertising.

This transcript is the record of an interview with photographer Elda Harrington about how technology affects her work as part of a lecture series, "Women Art Technology." During the interview, Harrington discusses her own work in photography as well as the schools and the photography festival that she has established in Argentina. The transcript includes a brief introduction with a biography of Harrington and general information about the lecture series and the specific interview. A list of 'Suggested reading' materials is also listed at the end of the transcript.

Weekly newspaper from Rusk, Texas that includes local, state and national news along with extensive advertising.

Daily student newspaper from the University of North Texas in Denton, Texas that includes local, state and campus news along with advertising.

Weekly student newspaper from Texas Wesleyan University in Fort Worth, Texas that includes campus and local news along with advertising.

Document issued by the Office of the Attorney General of Texas in Austin, Texas, providing an interpretation of Texas law. It provides the opinion of the Texas Attorney General, Greg Abbott, regarding a legal question submitted for clarification: Whether a municipality must pay a fire fighter or police officer for an appearance as a witness in a civil service hearing before a hearing examiner when the fire fighter or police officer is subpoenaed in his or her capacity as a fire fighter or police officer and testifies during time off (RQ-0633-GA)

This report discusses Taiwan's 2008 presidential elections.