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01-ERD-111 - The Development of Synthetic High Affinity Ligands
The aim of this project was to develop Synthetic High-Affinity Ligands (SHALs), which bind with high affinity and specificity to proteins of interest for national security and cancer therapy applications. The aim of producing synthetic ligands for sensory devices as an alternative to antibody-based detection assays and therapeutic agents is to overcome the drawbacks associated with antibody-based in next-generation sensors and systems. The focus area of the project was the chemical synthesis of the SHALs. The project concentrated on two different protein targets. (a) The C fragment of tetanus and botulinum toxin, potential biowarfare agents. A SHAL for tetanus or botulinum toxin would be incorporated into a sensory device for the toxins. (b) HLA-DR10, a protein found in high abundance on the surface of Non-Hodgkins Lymphoma. A SHAL specific to a tumor marker, labeled with a radionuclide, would enable the targeted delivery of radiation therapy to metastatic disease. The technical approach used to develop a SHAL for each protein target will be described in more detail below. However, in general, the development of a SHAL requires a combination of computational modeling techniques, modern nuclear magnetic resonance spectroscopy (NMR) and synthetic chemistry.
Date:
February 5, 2004
Creator:
Perkins, J; Balhorn, R; Cosman, M; Lightstone, F & Zeller, L
Object Type:
Report
System:
The UNT Digital Library
21st Century Community Learning Centers: Background and Funding
This report summarizes the reauthorized Elementary and Secondary Education Act (ESEA) which contains the 21st Century Community Learning Centers (21st CCLC) program. The report covers the history of the ESEA as well as what is new in the reauthorization. Moreover, the report includes how grants are selected now, and the new focus of the program which is now exclusively for after-school-hours activities for children.
Date:
February 5, 2008
Creator:
McCallion, Gail
Object Type:
Report
System:
The UNT Digital Library
78th Texas Legislature, Regular Session, House Concurrent Resolution 26
Concurrent resolution introduced by the Texas House of Representatives and Senate relating to honoring soldiers from Fort Hood who are being deployed for Operation Enduring Freedom.
Date:
February 5, 2003
Creator:
Texas. Legislature. House of Representatives.
Object Type:
Legislative Document
System:
The Portal to Texas History
78th Texas Legislature, Regular Session, Senate Concurrent Resolution 4
Concurrent resolution introduced by the Texas Senate and House of Representatives relating to January 13 through January 26, 2003, as the Texas Centennial of Flight Celebration.
Date:
February 5, 2003
Creator:
Texas. Legislature. Senate.
Object Type:
Legislative Document
System:
The Portal to Texas History
Abstract - INMM Annual Meeting 1998 Status of Underground Testing Program
This report is about the INMM Annual Meeting 1998 Status of Underground Testing Program.
Date:
February 5, 2008
Creator:
Dr. William J. Boyle, Larry R. Hayes, Alan J. Mitchell
Object Type:
Article
System:
The UNT Digital Library
Accelerator/Experiment Operations - FY 2001 Through FY 2003
This Technical Memorandum (TM) summarizes the accelerator and experiment operations for the period FY 2001 through FY 2003. The plan is to have an annual TM to gather such information in one place. In this case, the information concerns the startup of Run II at the Tevatron Collider and the beginning of the MiniBooNE neutrino experiment. While the focus is on the FY 2003 efforts, this document includes summaries of the earlier years where available for completeness.
Date:
February 5, 2004
Creator:
al., Jeffrey A. Appel et
Object Type:
Report
System:
The UNT Digital Library
Accomplishments Achieved Under DOE Grant Number DE-FG03-92ER40693: The Physics of Gain Mechanisms in Self-Amplified Spontaneous Emission in Free Electron Lasers
None
Date:
February 5, 2007
Creator:
Rosenzweig, James
Object Type:
Report
System:
The UNT Digital Library
Adapting high-resolution speckle imaging to moving targets and platforms
High-resolution surveillance imaging with apertures greater than a few inches over horizontal or slant paths at optical or infrared wavelengths will typically be limited by atmospheric aberrations. With static targets and static platforms, we have previously demonstrated near-diffraction limited imaging of various targets including personnel and vehicles over horizontal and slant paths ranging from less than a kilometer to many tens of kilometers using adaptations to bispectral speckle imaging techniques. Nominally, these image processing methods require the target to be static with respect to its background during the data acquisition since multiple frames are required. To obtain a sufficient number of frames and also to allow the atmosphere to decorrelate between frames, data acquisition times on the order of one second are needed. Modifications to the original imaging algorithm will be needed to deal with situations where there is relative target to background motion. In this paper, we present an extension of these imaging techniques to accommodate mobile platforms and moving targets.
Date:
February 5, 2004
Creator:
Carrano, C J & Brase, J M
Object Type:
Article
System:
The UNT Digital Library
Advanced Large Area Plastic Scintillator Project (ALPS): Final Report
The advanced Large-Area Plastic Scintillator (ALPS) Project at Pacific Northwest National Laboratory investigated possible technological avenues for substantially advancing the state-of-the-art in gamma-ray detection via large-area plastic scintillators. The three predominant themes of these investigations comprised the following: * Maximizing light collection efficiency from a single large-area sheet of plastic scintillator, and optimizing hardware event trigger definition to retain detection efficiency while exploiting the power of coincidence to suppress single-PMT "dark current" background; * Utilizing anti-Compton vetoing and supplementary spectral information from a co-located secondary, or "Back" detector, to both (1) minimize Compton background in the low-energy portion of the "Front" scintillator's pulse-height spectrum, and (2) sharpen the statistical accuracy of the front detector's low-energy response prediction as impelmented in suitable energy-windowing algorithms; and * Investigating alternative materials to enhance the intrinsic gamma-ray detection efficiency of plastic-based sensors.
Date:
February 5, 2008
Creator:
Jordan, David V.; Reeder, Paul L.; Todd, Lindsay C.; Warren, Glen A.; McCormick, Kathleen R.; Stephens, Daniel L. et al.
Object Type:
Report
System:
The UNT Digital Library
Afghanistan: Government Formation and Performance
This report discusses the current political state of Afghanistan, as well as the Afghan government. This report also discusses Afghanistan's relationship with the United States, particularly U.S. efforts to urge President Hamid Karzai to address corruption within the Afghan government.
Date:
February 5, 2009
Creator:
Katzman, Kenneth
Object Type:
Report
System:
The UNT Digital Library
The Albany News (Albany, Tex.), Vol. 128, No. 35, Ed. 1 Thursday, February 5, 2004
Weekly newspaper from Albany, Texas that includes local, county, and state news along with extensive advertising.
Date:
February 5, 2004
Creator:
Lucas, Melinda L.
Object Type:
Newspaper
System:
The Portal to Texas History
The Albany News (Albany, Tex.), Vol. 133, No. 37, Ed. 1 Thursday, February 5, 2009
Weekly newspaper from Albany, Texas that includes local, county, and state news along with extensive advertising.
Date:
February 5, 2009
Creator:
Lucas, Melinda L.
Object Type:
Newspaper
System:
The Portal to Texas History
Altus Times (Altus, Okla.), Vol. 101, No. 280, Ed. 1 Monday, February 5, 2001
Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date:
February 5, 2001
Creator:
Bush, Michael
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Altus Times (Altus, Okla.), Vol. 103, No. 291, Ed. 1 Tuesday, February 5, 2002
Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date:
February 5, 2002
Creator:
Bush, Michael
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Altus Times (Altus, Okla.), Vol. 105, No. 278, Ed. 1 Thursday, February 5, 2004
Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date:
February 5, 2004
Creator:
Andrews, Mike
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Altus Times (Altus, Okla.), Vol. 107, No. 260, Ed. 1 Sunday, February 5, 2006
Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date:
February 5, 2006
Creator:
Bush, Michael
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
The Altus Times (Altus, Okla.), Vol. 108, No. 267, Ed. 1 Monday, February 5, 2007
Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date:
February 5, 2007
Creator:
Bush, Michael
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
The Altus Times (Altus, Okla.), Vol. 109, No. 212, Ed. 1 Tuesday, February 5, 2008
Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date:
February 5, 2008
Creator:
Bush, Michael
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
The Altus Times (Altus, Okla.), Vol. 111, No. 151, Ed. 1 Thursday, February 5, 2009
Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date:
February 5, 2009
Creator:
Bush, Michael
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Aluminum--Industry of the Future; Industrial Partnerships: Advancing Energy and Environmental Goals
This tri-fold brochure describe the partnering activities of the Office of Industrial Technologies' (OIT) Industries of the Future (IOF) for Aluminum. Information on what works for the Aluminum industry, examples of successful partnerships, and benefits of partnering with OIT are included.
Date:
February 5, 2001
Creator:
Jones, A.
Object Type:
Book
System:
The UNT Digital Library
The Alvin Advertiser (Alvin, Tex.), Ed. 1 Wednesday, February 5, 2003
Weekly newspaper from Alvin, Texas that includes local, state, and national news along with advertising.
Date:
February 5, 2003
Creator:
Schwind, Jim & Holton, Kathleen
Object Type:
Newspaper
System:
The Portal to Texas History
The Alvin Sun (Alvin, Tex.), Vol. 110, No. 11, Ed. 1 Monday, February 5, 2001
Weekly newspaper from Alvin, Texas that includes local, state, and national news along with advertising.
Date:
February 5, 2001
Creator:
Schwind, Jim & Holton, Kathleen
Object Type:
Newspaper
System:
The Portal to Texas History
Anodic Behavior of Specimens Prepared from a Full-Diameter Alloy 22 Fabricated Container
Alloy 22 (N06022) has been extensively tested for general and localized corrosion behavior both in the wrought and annealed condition and in the as-welded condition. The specimens for testing were mostly prepared from flat plates of material. It was important to determine if the process of fabricating a full diameter Alloy 22 container will affect the corrosion performance of the alloy. Specimens were prepared directly from a fabricated container and tested for corrosion resistance. Results show that both the anodic corrosion behavior and the localized corrosion resistance of specimens prepared from a welded fabricated container was the same as from flat welded plates.
Date:
February 5, 2005
Creator:
King, K. J.; Estill, J. C. & Rebak, R. B.
Object Type:
Article
System:
The UNT Digital Library
Application of Frequency Domain Substructure Synthesis Technique for Plates Loaded with Complex Attachments
Frequency domain substructure synthesis is a modeling technique that enables the prediction of a combined response of individual structures using experimentally measured or numerically predicted frequency response functions (FRFs). The traditional synthesis algorithm [1,2] operates on component impedances and thus generally requires several matrix inversions. An improved algorithm, developed by Jetmundsen et al. [3], requires a single matrix inversion with a completely arbitrary interface definition that can easily incorporate connection impedances. The main limitations of the method are the large data requirements and sensitivity to data truncation. The utility of this technique is demonstrated through a comparison of synthesized and measured admittances of an edge-stiffened plate with attached equipment. The plate mobilities are obtained from a numerical analysis because of the ability to accurately model this structure using a finite element representation. The attachments are characterized experimentally because of their complexity. The sections describe the synthesis technique and show numerical and experimental results for the plate and equipment.
Date:
February 5, 2004
Creator:
Campbell, RL & Hambric, SA
Object Type:
Report
System:
The UNT Digital Library