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Alternative pre-mRNA splicing switches modulate gene expression in late erythropoiesis (open access)

Alternative pre-mRNA splicing switches modulate gene expression in late erythropoiesis

Differentiating erythroid cells execute a unique gene expression program that insures synthesis of the appropriate proteome at each stage of maturation. Standard expression microarrays provide important insight into erythroid gene expression but cannot detect qualitative changes in transcript structure, mediated by RNA processing, that alter structure and function of encoded proteins. We analyzed stage-specific changes in the late erythroid transcriptome via use of high-resolution microarrays that detect altered expression of individual exons. Ten differentiation-associated changes in erythroblast splicing patterns were identified, including the previously known activation of protein 4.1R exon 16 splicing. Six new alternative splicing switches involving enhanced inclusion of internal cassette exons were discovered, as well as 3 changes in use of alternative first exons. All of these erythroid stage-specific splicing events represent activated inclusion of authentic annotated exons, suggesting they represent an active regulatory process rather than a general loss of splicing fidelity. The observation that 3 of the regulated transcripts encode RNA binding proteins (SNRP70, HNRPLL, MBNL2) may indicate significant changes in the RNA processing machinery of late erythroblasts. Together, these results support the existence of a regulated alternative pre-mRNA splicing program that is critical for late erythroid differentiation.
Date: February 3, 2009
Creator: Yamamoto, Miki L.; Clark, Tyson A.; Gee, Sherry L.; Kang, Jeong-Ah; Schweitzer, Anthony C.; Wickrema, Amittha et al.
Object Type: Article
System: The UNT Digital Library
The Altus Times (Altus, Okla.), Vol. 111, No. 149, Ed. 1 Tuesday, February 3, 2009 (open access)

The Altus Times (Altus, Okla.), Vol. 111, No. 149, Ed. 1 Tuesday, February 3, 2009

Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date: February 3, 2009
Creator: Bush, Michael
Object Type: Newspaper
System: The Gateway to Oklahoma History
Analysis of Trade-Off Between Power Saving and Response Time in Disk Storage Systems (open access)

Analysis of Trade-Off Between Power Saving and Response Time in Disk Storage Systems

It is anticipated that in the near future disk storage systems will surpass application servers and will become the primary consumer of power in the data centers. Shutting down of inactive disks is one of the more widespread solutions to save power consumption of disk systems. This solution involves spinning down or completely shutting off disks that exhibit long periods of inactivity and placing them in standby mode. A file request from a disk in standby mode will incur an I/O cost penalty as it takes time to spin up the disk before it can serve the file. In this paper, we address the problem of designing and implementing file allocation strategies on disk storage that save energy while meeting performance requirements of file retrievals. We present an algorithm for solving this problem with guaranteed bounds from the optimal solution. Our algorithm runs in O(nlogn) time where n is the number of files allocated. Detailed simulation results and experiments with real life workloads are also presented.
Date: February 3, 2009
Creator: Otoo, Ekow J; Rotem, Doron & Tsao, Shih-Chiang
Object Type: Article
System: The UNT Digital Library
The Bayh-Dole Act: Selected Issues in Patent Policy and the Commercialization of Technology (open access)

The Bayh-Dole Act: Selected Issues in Patent Policy and the Commercialization of Technology

This report discusses the rationale behind the passage of P.L. 96-517 (Amendments to the Patent and Trademark Act, or the "Bayh-Dole Act") as well as its provisions and information regarding the implementation of the law. Under this 1980 law, as amended, title to inventions made with government support is provided to the contractor if that contractor is a small business, a university, or other non-profit institution.
Date: February 3, 2009
Creator: Schacht, Wendy H.
Object Type: Report
System: The UNT Digital Library
The Baytown Sun (Baytown, Tex.), Vol. 89, No. 34, Ed. 1 Tuesday, February 3, 2009 (open access)

The Baytown Sun (Baytown, Tex.), Vol. 89, No. 34, Ed. 1 Tuesday, February 3, 2009

Daily newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date: February 3, 2009
Creator: Clements, Clifford E.
Object Type: Newspaper
System: The Portal to Texas History
Biochar: Examination of an Emerging Concept to Mitigate Climate Change (open access)

Biochar: Examination of an Emerging Concept to Mitigate Climate Change

This report briefly describes biochar, its potential advantages and disadvantages, legislative support, and research and development activities underway in the United States and abroad.
Date: February 3, 2009
Creator: Bracmort, Kelsi S.
Object Type: Report
System: The UNT Digital Library
Biochar: Examination of an Emerging Concept to Mitigate Climate Change (open access)

Biochar: Examination of an Emerging Concept to Mitigate Climate Change

This report briefly describes biochar, its potential advantages and disadvantages, legislative support, and research and development activities underway in the United States and abroad.
Date: February 3, 2009
Creator: Bracmort, Kelsi S.
Object Type: Report
System: The UNT Digital Library
The Boerne Star (Boerne, Tex.), Vol. 103, No. 10, Ed. 1 Tuesday, February 3, 2009 (open access)

The Boerne Star (Boerne, Tex.), Vol. 103, No. 10, Ed. 1 Tuesday, February 3, 2009

Semiweekly newspaper from Boerne, Texas that includes local, state, and national news along with advertising.
Date: February 3, 2009
Creator: Cartwright, Brian
Object Type: Newspaper
System: The Portal to Texas History

Bright Future for CPV

Concentrator photovoltaics may play significant role in growth of solar electricity because of scalability. Need to take a bird?s eye view for the design and a worm?s eye view for diagnosis.
Date: February 3, 2009
Creator: Kurtz, S.
Object Type: Presentation
System: The UNT Digital Library
Cuba: Issues for the 111th Congress (open access)

Cuba: Issues for the 111th Congress

This report discusses the current political conditions of Cuba, as well as its relationship with the United States. In particular, the report focuses on U.S. policy regarding Cuba, including various economic sanctions, human rights issues, and foreign aid appropriations.
Date: February 3, 2009
Creator: Sullivan, Mark P.
Object Type: Report
System: The UNT Digital Library
Elements of Successful and Safe Fusion Experiment Operations (open access)

Elements of Successful and Safe Fusion Experiment Operations

A group of fusion safety professionals contribute to a Joint Working Group (JWG) that performs occupational safety walkthroughs of US and Japanese fusion experiments on a routine basis to enhance the safety of visiting researchers. The most recent walkthrough was completed in Japan in March 2008 by the US Safety Monitor team. This paper gives the general conclusions on fusion facility personnel safety that can be drawn from the series of walkthroughs.
Date: February 3, 2009
Creator: Rule, K.; Cadwallader, L.; Takase, Y.; Norimatsu, T.; Kaneko, O.; Sato, M. et al.
Object Type: Article
System: The UNT Digital Library
The Endangered Species Act (ESA) and Claims of Property Rights "Takings" (open access)

The Endangered Species Act (ESA) and Claims of Property Rights "Takings"

This report outlines the ESA provisions most relevant to the act's impacts on private property and surveys the major ESA-relevant principles of Fifth Amendment takings law. The report then proceeds to the court decisions adjudicating whether government measures based on the ESA effect a taking of property under the Fifth Amendment.
Date: February 3, 2009
Creator: Meltz, Robert
Object Type: Report
System: The UNT Digital Library

Faculty Recital: 2009-02-03 - Jazz Faculty

Access: Use of this item is restricted to the UNT Community
Jazz concert performed at the UNT College of Music Kenton Hall.
Date: February 3, 2009
Creator: Steinel, Mike
Object Type: Sound
System: The UNT Digital Library

Faculty Recital: 2009-02-03 - Mary Karen Clardy et al

Access: Use of this item is restricted to the UNT Community
Winds with piano concert performed at the UNT College of Music Recital Hall.
Date: February 3, 2009
Creator: Clardy, Mary Karen
Object Type: Sound
System: The UNT Digital Library
Federal R&D, Drug Discovery, and Pricing: Insights from the NIH-University-Industry Relationship (open access)

Federal R&D, Drug Discovery, and Pricing: Insights from the NIH-University-Industry Relationship

This report explores the reasons behind government funding of research and development and subsequent efforts to facilitate private sector commercialization of the results of such work, without addressing issues associated with drug costs or pricing. It particularly looks at the manner in which the National Institutes of Health (NIH) supports research to encourage the development of new pharmaceuticals and therapeutics, particularly through cooperative activities among academia, industry, and government.
Date: February 3, 2009
Creator: Schacht, Wendy H.
Object Type: Report
System: The UNT Digital Library
Federal Register, Volume 74, Number 21, February 3, 2009, Pages 5899-5982 (open access)

Federal Register, Volume 74, Number 21, February 3, 2009, Pages 5899-5982

Daily publication of the U.S. Office of the Federal Register contains rules and regulations, proposed legislation and rule changes, and other notices, including "Presidential proclamations and Executive Orders, Federal agency documents having general applicability and legal effect, documents required to be published by act of Congress, and other Federal agency documents of public interest" (p. ii). Table of Contents starts on page iii.
Date: February 3, 2009
Creator: United States. Office of the Federal Register.
Object Type: Journal/Magazine/Newsletter
System: The UNT Digital Library
Greensheet (Houston, Tex.), Vol. 40, No. 1, Ed. 1 Tuesday, February 3, 2009 (open access)

Greensheet (Houston, Tex.), Vol. 40, No. 1, Ed. 1 Tuesday, February 3, 2009

Free weekly newspaper that includes business and classified advertising.
Date: February 3, 2009
Creator: unknown
Object Type: Newspaper
System: The Portal to Texas History
Greensheet (Houston, Tex.), Vol. 40, No. 2, Ed. 1 Tuesday, February 3, 2009 (open access)

Greensheet (Houston, Tex.), Vol. 40, No. 2, Ed. 1 Tuesday, February 3, 2009

Free weekly newspaper that includes business and classified advertising.
Date: February 3, 2009
Creator: unknown
Object Type: Newspaper
System: The Portal to Texas History
Haloarchaeal Protein Translocation via the Twin Arginine Translocation Pathway (open access)

Haloarchaeal Protein Translocation via the Twin Arginine Translocation Pathway

Protein transport across hydrophobic membranes that partition cellular compartments is essential in all cells. The twin arginine translocation (Tat) pathway transports proteins across the prokaryotic cytoplasmic membranes. Distinct from the universally conserved Sec pathway, which secretes unfolded proteins, the Tat machinery is unique in that it secretes proteins in a folded conformation, making it an attractive pathway for the transport and secretion of heterologously expressed proteins that are Sec-incompatible. During the past 7 years, the DOE-supported project has focused on the characterization of the diversity of bacterial and archaeal Tat substrates as well as on the characterization of the Tat pathway of a model archaeon, Haloferax volcanii, a member of the haloarchaea. We have demonstrated that H. volcanii uses this pathway to transport most of its secretome.
Date: February 3, 2009
Creator: Mechthild, Pohlschroder
Object Type: Report
System: The UNT Digital Library
Iraq: Politics, Elections, and Benchmarks (open access)

Iraq: Politics, Elections, and Benchmarks

This report discusses Iraq's political system, which has been restructured through a U.S.-supported election process, as well as issues relating to opponents of the Iraqi Prime Minister Nuri al-Maliki and the atmosphere of nationwide provincial elections.
Date: February 3, 2009
Creator: Katzman, Kenneth
Object Type: Report
System: The UNT Digital Library
Measurements and Simulations of Ultra-Low Emittance and Ultra-Short Electron Beams in the Linac Coherent Light Source (open access)

Measurements and Simulations of Ultra-Low Emittance and Ultra-Short Electron Beams in the Linac Coherent Light Source

The Linac Coherent Light Source (LCLS) is an x-ray Free-Electron Laser (FEL) project presently in a commissioning phase at SLAC. We report here on very low emittance measurements made at low bunch charge, and a few femtosecond bunch length produced by the LCLS bunch compressors. Start-to-end simulations associated with these beam parameters show the possibilities of generating hundreds of GW at 1.5 {angstrom} x-ray wavelength and nearly a single longitudinally spike at 1.5 nm with 2-fs duration.
Date: February 3, 2009
Creator: Ding, Y.; Brachmann, A.; Decker, F. J.; Dowell, D.; Emma, P.; Frisch, J. et al.
Object Type: Article
System: The UNT Digital Library
North Texas Daily (Denton, Tex.), Vol. 93, No. 8, Ed. 1 Tuesday, February 3, 2009 (open access)

North Texas Daily (Denton, Tex.), Vol. 93, No. 8, Ed. 1 Tuesday, February 3, 2009

Daily student newspaper from the University of North Texas in Denton, Texas that includes local, state and campus news along with advertising.
Date: February 3, 2009
Creator: unknown
Object Type: Newspaper
System: The Portal to Texas History
Novel imaging techniques, integrated with mineralogical, geochemical and microbiological characterizations to determine the biogeochemical controls on technetium mobility in FRC sediments (open access)

Novel imaging techniques, integrated with mineralogical, geochemical and microbiological characterizations to determine the biogeochemical controls on technetium mobility in FRC sediments

The objective of this research program was to take a highly multidisciplinary approach to define the biogeochemical factors that control technetium (Tc) mobility in FRC sediments. The aim was to use batch and column studies to probe the biogeochemical conditions that control the mobility of Tc at the FRC. Background sediment samples from Area 2 (pH 6.5, low nitrate, low {sup 99}Tc) and Area 3 (pH 3.5, high nitrate, relatively high {sup 99}Tc) of the FRC were selected (http://www.esd.ornl.gov/nabirfrc). For the batch experiments, sediments were mixed with simulated groundwater, modeled on chemical constituents of FRC waters and supplemented with {sup 99}Tc(VII), both with and without added electron donor (acetate). The solubility of the Tc was monitored, alongside other biogeochemical markers (nitrate, nitrite, Fe(II), sulfate, acetate, pH, Eh) as the 'microcosms' aged. At key points, the microbial communities were also profiled using both cultivation-dependent and molecular techniques, and results correlated with the geochemical conditions in the sediments. The mineral phases present in the sediments were also characterized, and the solid phase associations of the Tc determined using sequential extraction and synchrotron techniques. In addition to the batch sediment experiments, where discrete microbial communities with the potential to reduce and precipitate {sup …
Date: February 3, 2009
Creator: Lloyd, Jonathan R.
Object Type: Report
System: The UNT Digital Library
The Oklahoma Daily (Norman, Okla.), Vol. 94, No. 87, Ed. 1 Tuesday, February 3, 2009 (open access)

The Oklahoma Daily (Norman, Okla.), Vol. 94, No. 87, Ed. 1 Tuesday, February 3, 2009

Student newspaper of the University of Oklahoma in Norman, Oklahoma that includes national, local, and campus news along with advertising.
Date: February 3, 2009
Creator: Simons, Meredith
Object Type: Newspaper
System: The Gateway to Oklahoma History