Age is one of the most important risk factors for human malignancies, including breast cancer; in addition, age-at-diagnosis has been shown to be an independent indicator of breast cancer prognosis. However, except for inherited forms of breast cancer, there is little genetic or epigenetic understanding of the biological basis linking aging with sporadic breast cancer incidence and its clinical behavior.

Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.

Purpose. This study was designed to elucidate the role of amplification at 8q24 in the pathophysiology of ovarian and breast cancer since increased copy number at this locus is one of the most frequent genomic abnormalities in these cancers. Experimental Design. To accomplish this, we assessed the association of amplification at 8q24 with outcome in ovarian cancers using FISH to tissue microarrays and measured responses of ovarian and breast cancer cell lines to specific small interfering RNAs (siRNA) against the oncogene, MYC, and a putative noncoding RNA, PVT1, both of which map to 8q24. Results. Amplification of 8q24 was associated with significantly reduced survival duration. In addition, siRNA-mediated reduction in either PVT1 or MYC expression inhibited proliferation in breast and ovarian cancer cell lines in which they were both amplified and over expressed but not in lines in which they were not amplified/over expressed. Inhibition of PVT1 expression also induced a strong apoptotic response in cell lines in which it was over expressed but not in lines in which it was not amplified/over expressed. Inhibition of MYC, on the other hand, did not induce an apoptotic response in cell lines in which MYC was amplified and over expressed. Conclusions. These …

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Daily newspaper from Baytown, Texas that includes local, state, and national news along with advertising.

Semiweekly newspaper from Boerne, Texas that includes local, state, and national news along with advertising.

In this lecture we presented a methodology to obtain free energies from empirical potentials and applied it to the study of the phase diagram of FeCr. Subsequently, we used Metropolis Monte Carlo to analyze homogeneous and heterogeneous precipitation of the Cr rich solid solution {alpha}{prime}. These examples are part of our work in the area of steels for nuclear applications and can be found in several publications of our group cited as References.

A typical optical fabrication process involves a series of basic process steps including: (1) shaping, (2) grinding, (3) polishing, and sometimes (4) sub-aperture tool finishing. With significant innovation and development over the years in both the front end (shaping using CNC machines) and the back end (sup-aperture tool polishing), these processes have become much more deterministic. However, the intermediate stages (full aperture grinding/polishing) in the process, which can be very time consuming, still have much reliance on the optician's insight to get to the desired surface figure. Such processes are not presently very deterministic (i.e. require multiple iterations to get desired figure). The ability to deterministically finish an optical surface using a full aperture grinding/polishing will aid optical glass fabricators to achieve desired figure in a more repeatable, less iterative, and more economical manner. Developing a scientific understanding of the material removal rate is a critical step in accomplishing this. In the present study, the surface figure and material removal rate of a fused silica workpiece is measured as a function of polishing time using Ceria based slurry on a polyurethane pad or pitch lap under a variety of kinematic conditions (motion of the workpiece and lap) and loading configurations. …

We discuss the contribution of kiloparsec-scale jets in FR I radio galaxies to the diffuse {gamma}-ray background radiation. The analyzed {gamma}-ray emission comes from inverse-Compton scattering of starlight photon fields by the ultrarelativistic electrons whose synchrotron radiation is detected from such sources at radio, optical and X-ray energies. We find that these objects, under the minimum-power hypothesis (corresponding to a magnetic field of 300 {micro}G in the brightest knots of these jets), can contribute about one percent to the extragalactic {gamma}-ray background measured by EGRET. We point out that this result already indicates that the magnetic fields in kpc-scale jets of low-power radio galaxies are not likely to be smaller than 10 {micro}G on average, as otherwise the extragalactic {gamma}-ray background would be overproduced.

Daily newspaper from Chickasha, Oklahoma that includes local, state, and national news along with advertising.

This report provides a brief history of federal Indian education programs, a discussion of data on students served by these programs, an overview of the programs and their funding, a discussion of the application to BIE schools of key provisions of the No Child Left Behind Act, and brief discussions of selected issues in Indian education.

The Savannah River Site (SRS) and Hanford site are in the process of stabilizing millions of gallons of radioactive waste slurries remaining from production of nuclear materials for the Department of Energy (DOE). The Defense Waste Processing Facility (DWPF) at SRS is currently vitrifying the waste in borosilicate glass, while the facilities at the Hanford site are in the construction phase. Both processes utilize slurry-fed joule-heated melters to vitrify the waste slurries. The DWPF has experienced difficulty during operations. The cause of the operational problems has been attributed to foaming, gas entrainment and the rheological properties of the process slurries. The rheological properties of the waste slurries limit the total solids content that can be processed by the remote equipment during the pretreatment and meter feed processes. Highly viscous material can lead to air entrainment during agitation and difficulties with pump operations. Excessive foaming in waste evaporators can cause carryover of radionuclides and non-radioactive waste to the condensate system. Experimental and theoretical investigations of the surface phenomena, suspension rheology and bubble generation of interactions that lead to foaming and air entrainment problems in the DOE High Level and Low Activity Radioactive Waste separation and immobilization processes were pursued under this …

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Free weekly newspaper that includes business and classified advertising.

Free weekly newspaper that includes business and classified advertising.

If the collisional time scale for Coulomb collisions is comparable to the characteristic time scales for a plasma, then simulation of Coulomb collisions may be important for computation of kinetic plasma dynamics. This can be a computational bottleneck because of the large number of simulated particles and collisions (or phase-space resolution requirements in continuum algorithms), as well as the wide range of collision rates over the velocity distribution function. This paper considers Monte Carlo simulation of Coulomb collisions using the binary collision models of Takizuka & Abe and Nanbu. It presents a hybrid method for accelerating the computation of Coulomb collisions. The hybrid method represents the velocity distribution function as a combination of a thermal component (a Maxwellian distribution) and a kinetic component (a set of discrete particles). Collisions between particles from the thermal component preserve the Maxwellian; collisions between particles from the kinetic component are performed using the method of or Nanbu. Collisions between the kinetic and thermal components are performed by sampling a particle from the thermal component and selecting a particle from the kinetic component. Particles are also transferred between the two components according to thermalization and dethermalization probabilities, which are functions of phase space.

Diagnosis and management of dust inventories generated in next-step magnetic fusion devices is necessary for their safe operation. A novel electrostatic dust detector, based on a fine grid of interlocking circuit traces biased to 30 or 50 ν has been developed for the detection of dust particles on remote surfaces in air and vacuum environments. Impinging dust particles create a temporary short circuit and the resulting current pulse is recorded by counting electronics. Up to 90% of the particles are ejected from the grid or vaporized suggesting the device may be useful for controlling dust inventories. We report measurements of the sensitivity of a large area (5x5 cm) detector to microgram quantities of dust particles and review its applications to contemporary tokamaks and ITER.

Letter from Ken Whalen to Charles Moser, with the subject "2008 Board Elections" stating that it is that time to begin the nomination process for the TDNA (Texas Daily Newspaper Association) board of directors and has enclosed various of information for Moser to review.

A Lower Hybrid Current Drive (LHCD) system has been installed on the Alcator C-MOD tokamak at MIT. Twelve klystrons at 4.6 GHz feed a 4x22 waveguide array. This system was designed for maximum flexibility in the launched parallel wave-number spectrum. This flexibility allows tailoring of the lower hybrid deposition under a variety of plasma conditions. Power levels up to 900 kW have been injected into the tokomak. The parallel wave number has been varied over a wide range, n|| ~ 1.6–4. Driven currents have been inferred from magnetic measurements by extrapolating to zero loop voltage and by direct comparison to Fisch-Karney theory, yielding an efficiency of n20IR/P ~ 0.3. Modeling using the CQL3D code supports these efficiencies. Sawtooth oscillations vanish, accompanied with peaking of the electron temperature (Te0 rises from 2.8 to 3.8 keV). Central q is inferred to rise above unity from the collapse of the sawtooth inversion radius, indicating off-axis cd as expected. Measurements of non-thermal x-ray and electron cyclotron emission confirm the presence of a significant fast electron population that varies with phase and plasma density. The x-ray emission is observed to be radialy broader than that predicted by simple ray tracing codes. Possible explanations for this …

By comparison with thermal neutrons, cold neutrons are attenuated to a greater extent by elements such as H, O, N, B, Cd, Gd and to a leser extent by metals such as Be, Al, Fe, Zr, Sn, W, Bi, Pb. Such unique nuclear properties to interact with materials enable to provide better non-destructive inspections.

The present state of the theory of fluctuations in gyrokinetic GK plasmas and especially its application to sampling noise in GK particle-in-cell PIC simulations is reviewed. Topics addressed include the Δf method, the fluctuation-dissipation theorem for both classical and GK many-body plasmas, the Klimontovich formalism, sampling noise in PIC simulations, statistical closure for partial differential equations, the theoretical foundations of spectral balance in the presence of arbitrary noise sources, and the derivation of Kadomtsev-type equations from the general formalism.

Daily student newspaper from the University of North Texas in Denton, Texas that includes local, state and campus news along with advertising.

Student newspaper of the University of Oklahoma in Norman, Oklahoma that includes national, local, and campus news along with advertising.

Interview with Sharon "Tommie" Acierno, Vietnam War veteran, as part of the Tarrant County War Veterans Oral History Project. The interview includes Acierno's personal experiences about childhood, dropping out of high school and enlisting in the U.S. Army, basic and clerical training, working as drill sergeant at Ft. McClellan, struggling with alcoholism and post-traumatic stress disorder, and working with the Vietnam Veterans of America group. Acierno also discusses her coming out experience, volunteering for assignment to Vietnam, her clerical duties with a logistics unit at Long Binh, the camaraderie among gay and straight troops, her experiences with apathetic citizens and antiwar protesters upon return to the U.S., deciding to leave the Army and relocate to Dallas, her experience in the Veterans Administration psychiatric ward, and her opinions regarding the "Don't ask, don't tell" policy and the treatment of women in the military generally. The interview includes an appendix with photographs.