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Altus Times-Democrat
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The Baytown Sun
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Chickasha Newspaper Collection
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9 Matching Results
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1 - 9 of
9
Electrospray mass spectrometry of NeuAc oligomers associated with the C fragment of the tetanus toxin
The Clostridial neurotoxins, botulinum and tetanus, gain entry into neuronal cells by protein recognition involving cell specific binding sites. The sialic or N-acetylneuraminic acid (NeuAc) residues of gangliosides attached to the surface of motor neurons are the suspected recognition and interaction points with Clostridial neurotoxins, although not necessarily the only ones. We have used electrospray ionization mass spectrometry (ESIMS) to examine formation of complexes between the tetanus toxin C fragment, or targeting domain, and carbohydrates containing NeuAc groups to determine how NeuAc residues contribute to ganglioside binding. ESI-MS was used to rapidly and efficiently measure dissociation constants for a number of related NeuAc-containing carbohydrates and NeuAc oligomers, information that has helped identify the structural features of gangliosides that determine their binding to tetanus toxin. The strength of the interactions between the C fragment and (NeuAc){sub n}, are consistent with the topography of the targeting domain of tetanus toxin and the nature of its carbohydrate binding sites. The results suggest that the targeting domain of tetanus toxin contains two binding sites that can accommodate NeuAc (or a dimer). This study also shows that NeuAc must play an important role in ganglioside binding and molecular recognition, a process critical for normal cell …
Date:
April 3, 2005
Creator:
Prieto, M C; Whittal, R M; Baldwin, M A; Burlingame, A L & Balhorn, R
Object Type:
Article
System:
The UNT Digital Library
Development of Polymer Gel Systems to Improve Volumetric Sweep and Reduce Producing Water/Oil Ratios
Gelled polymer treatments are applied to oil reservoirs to increase oil production and to reduce water production by altering the fluid movement within the reservoir. This report describes the results of the third year of a 42 month research program that is aimed at an understanding of gelation chemistry and the fundamental mechanisms that alter the flows of oil and water in reservoir rocks after a gel treatment. Work focused on a widely applied system in the field, the partially hydrolyzed polyacrylamide-chromium acetate gel. Gelation occurs by network formation through the crosslinking of polyacrylamide molecules as a result of reaction with chromium acetate. Pre-gel aggregates form and grow as reactions between chromium acetate and polyacrylamide proceed. A mathematical model that describes uptake and crosslinking reactions as a function of time was derived. The model was probability based and provides molecular-weight averages and molecular-weight distributions of the pre-gel aggregates as a function of time and initial system conditions. A liquid chromatography apparatus to experimentally measure the size and molecular weight distributions of polymer samples was developed. The method worked well for polymer samples without the chromium crosslinker. Sample retention observed during measurements of gelant samples during the gelation process compromised the …
Date:
April 3, 2005
Creator:
Willhite, G. Paul; McCool, Stan; Green, Don W.; Cheng, Min & Chen, Feiyan
Object Type:
Report
System:
The UNT Digital Library
Polk County Enterprise (Livingston, Tex.), Vol. 123, No. 27, Ed. 1 Sunday, April 3, 2005
Semi-weekly newspaper from Livingston, Texas that includes local, state and national news along with advertising.
Date:
April 3, 2005
Creator:
White, Barbara
Object Type:
Newspaper
System:
The Portal to Texas History
Levelland and Hockley County News-Press (Levelland, Tex.), Vol. 28, No. 1, Ed. 1 Sunday, April 3, 2005
Semiweekly newspaper from Levelland, Texas that includes local, state, and national news along with advertising.
Date:
April 3, 2005
Creator:
Rigg, John
Object Type:
Newspaper
System:
The Portal to Texas History
Altus Times (Altus, Okla.), Vol. 107, No. 2, Ed. 1 Sunday, April 3, 2005
Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.
Date:
April 3, 2005
Creator:
Andrews, Mike
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
The Express-Star (Chickasha, Okla.), Ed. 1 Sunday, April 3, 2005
Daily newspaper from Chickasha, Oklahoma that includes local, state, and national news along with advertising.
Date:
April 3, 2005
Creator:
Bush, Kent
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Sapulpa Daily Herald (Sapulpa, Okla.), Vol. 90, No. 174, Ed. 1 Sunday, April 3, 2005
Daily newspaper from Sapulpa, Oklahoma that includes local, state, and national news along with advertising.
Date:
April 3, 2005
Creator:
Broaddus, Matthew B.
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
The Baytown Sun (Baytown, Tex.), Vol. 84, No. 120, Ed. 1 Sunday, April 3, 2005
Daily newspaper from Baytown, Texas that includes local, state, and national news along with advertising.
Date:
April 3, 2005
Creator:
Cash, Wanda Garner
Object Type:
Newspaper
System:
The Portal to Texas History
The Panola Watchman (Carthage, Tex.), Vol. 132, No. 26, Ed. 1 Sunday, April 3, 2005
Semiweekly newspaper from Carthage, Texas that includes local, state, and national news along with advertising.
Date:
April 3, 2005
Creator:
unknown
Object Type:
Newspaper
System:
The Portal to Texas History