Correspondence issued by the General Accounting Office with an abstract that begins "GAO reviewed the progress of the new 155mm Lightweight Howitzer program. GAO found that since July 2000, all key program milestones have continued to slip. Only the initial fielding date for the howitzer remains unchanged. Since July 2000, the total program cost estimates have increased from $1,129.9 million to $1,250.2 million, an increase of $120.3 million. In addition, GAO found four technical problems yet to be addressed in the program: (1) cracking of the spades used to anchor the howitzer, (2) loose spade latches that create difficulties in removing the spades from the ground, (3) the spade damper--a device intended to help the spade dig into the soil to stabilize the gun--does not work properly in all soil types, and (4) the durability of the optical sight being developed for the gun. Design solutions have been identified for each of these problems, according to the Army-Marine Corps Lightweight Howitzer Joint Program Office. These design changes have not been fully incorporated and field tested to date."

Correspondence issued by the General Accounting Office with an abstract that begins "The Department of Agriculture's Rural Development Service (RDS) long-standing problems with estimating the cost of its credit programs in accordance with the Federal Credit Reform Act of 1990 and federal accounting standards continues to be a major factor in preventing Agriculture from achieving an unqualified opinion on its consolidated financial statements. This correspondence focuses on RDS's efforts to improve its credit program cost estimates for its major non-housing direct loan programs. Reliable data is essential if RDS is to prepare reasonable subsidy cost estimates. GAO found that the data in RDS's three loan accounting systems that are used to calculate key cash flow assumptions for the major non-housing direct loan programs are generally accurate. The assumptions that RDS has determined to be key for calculating the subsidy cost estimates for these programs are the average borrower interest rate and average loan term. For this program, RDS staff identified the average borrower interest rate as the key cash flow assumption."

A letter report issued by the General Accounting Office with an abstract that begins "During the last several years, the United States has criticized Germany's handling of international parental child abduction cases that have been filed by U.S. parents. Both the executive and legislative branches of the U.S. government have criticized Germany for not fully and consistently following the criteria and procedures established under the 1980 Hague Convention on the Civil Aspects of International Child Abduction, which governs such cases. The primary criticisms include the inappropriate use by German courts of certain provisions of the Hague Convention to justify retaining abducted children in Germany, the length of time it has taken to adjudicate cases, and the failure to enforce left-behind parents' visitation rights. GAO examined the actions that Germany has taken or plans to take to reform its handling of international parental child abduction cases and how these actions may affect U.S. cases. GAO found that German authorities have pledged their commitment to take steps to improve the handling of Hague Convention cases and Germany has taken action to address two of the three primary criticisms. Germany has established a task force to monitor German reforms and active cases, initiated …

A chapter report issued by the General Accounting Office with an abstract that begins "GAO examined how best practices could help the Department of Defense (DOD) maximize the benefits of integrated product teams in its development of weapon systems. GAO conducted eight case studies--three from leading commercial firms; four from DOD programs experiencing cost, schedule, and performance problems; and one from a DOD program that has been meeting its objectives. GAO found that effective integrated product teams can make significant development decisions quickly and without relying on heavy consultations with organizations outside of the team. These teams have developed and delivered superior products within predicted time frames and budgets--often cutting calendar time in half compared with earlier products delivered without such teams. Officials from the more successful programs GAO reviewed--three commercial and one from DOD--all cited integrated product teams as a main factor in achieving such results. GAO found that the teams did not operate as effectively in the four DOD programs that were not meeting cost and schedule objectives. Their decision-making processes were sequential and involved many outside consultations for information and approval."

A letter report issued by the General Accounting Office with an abstract that begins "Under TRICARE, the Department of Defense's (DOD) managed care program, military-operated hospitals and clinics are supplemented by contracted civilian services. Since the inception of TRICARE, DOD has made many changes to these contracts via contract change orders. Since July 1997, when GAO reported that DOD was trying to improve its change order process, the backlog of change orders has continued to grow. This report evaluates (1) the status of the change order backlog and how DOD addressed it, (2) factors that contributed to the growth of the backlog, and (3) DOD's new initiative to improve the change order process. GAO found that as of June, 2000, the number of change orders issued had almost tripled, while the number of unsettled change orders had more than doubled since July 1997. Despite recommendations to devote high-level attention to managing improvements to the change order process, this was not done. Until recently, none of TRICARE Management Activity's (TMA) many initiatives significantly improved the process or reduced the backlog. The current small backlog is the result of recent concerted effort, not better management over time. TMA's new Change Management Process …

Documents related to the Finance Chair Report presented at the WASP board meeting in Corpus Christi in April 2001. They include a balance sheet, a profit and loss statement, a budget listing revenue and expenses, the Finance Chair Report, the Treasurer's Report, and a proposal about finding candidates to serve as treasurer.

Unsaturated zone (UZ) flow and radionuclide transport is a component of the natural barriers that affects potential repository performance. The total system performance assessment (TSPA) model, and underlying process models, of this natural barrier component capture some, but not all, of the associated features, events, and processes (FEPs) as identified in the FEPs Database (Freeze, et al. 2001 [154365]). This analysis and model report (AMR) discusses all FEPs identified as associated with UZ flow and radionuclide transport. The purpose of this analysis is to give a comprehensive summary of all UZ flow and radionuclide transport FEPs and their treatment in, or exclusion from, TSPA models. The scope of this analysis is to provide a summary of the FEPs associated with the UZ flow and radionuclide transport and to provide a reference roadmap to other documentation where detailed discussions of these FEPs, treated explicitly in TSPA models, are offered. Other FEPs may be screened out from treatment in TSPA by direct regulatory exclusion or through arguments concerning low probability and/or low consequence of the FEPs on potential repository performance. Arguments for exclusion of FEPs are presented in this analysis. Exclusion of specific FEPs from the UZ flow and transport models does …

Non-homologous end joining (NHEJ) is a major pathway for the repair of DNA double-strand breaks in mammalian cells. DNA-dependent protein kinase (DNA-PK), ligase IV, and XRCC4 are all critical components of the NHEJ repair pathway. DNA-PK is composed of a heterodimeric DNA-binding component, Ku, and a large catalytic subunit, DNA-PKcs. Ligase IV and XRCC4 associate to form a multimeric complex that is also essential for NHEJ. DNA-PK and ligase IV/XRCC4 interact at DNA termini which results in stimulated ligase activity. Here we define interactions between the components of these two essential complexes, DNA-PK and ligase IV/XRCC4. We find that ligase IV/XRCC4 associates with DNA-PK in a DNA-independent manner. The specific protein-protein interactions that mediate the interaction between these two complexes are further identified. Direct physical interactions between ligase IV and Ku as well as between XRCC4 and DNA-PKcs are shown. No direct interactions are observed between ligase IV and DNA-PKcs or between XRCC4 and Ku. Our data defines the specific protein pairs involved in the association of DNA-PK and ligase IV/XRCC4, and suggests a molecular mechanism for coordinating the assembly of the DNA repair complex at DNA breaks.

This report describes the operation and setup of the Nuclear Materials Identification System (NMIS) with a {sup 252}Cf neutron source at the Oak Ridge Y-12 Plant. The components of the system are described with a description of the setup of the system along with an overview of the NMIS measurements for scanning, calibration, and confirmation of inventory items.

The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is critical for DNA repair via the non-homologous end joining (NHEJ) pathway. Previously, it was reported that bone marrow cells and spontaneously transformed fibroblasts from SCID (severe combined immunodeficiency) mice have defects in telomere maintenance. The genetically defective SCID mouse arose spontaneously from its parental strain CB17. One known genomic alteration in SCID mice is a truncation of the extreme carboxyl-terminus of DNA-PKcs, but other as yet unidentified alterations may also exist. We have used a defined system, the DNA-PKcs knockout mouse, to investigate specifically the role DNA-PKcs specifically plays in telomere maintenance. We report that primary mouse embryonic fibroblasts (MEFs) and primary cultured kidney cells from 6-8 month old DNA-PKcs deficient mice accumulate a large number of telomere fusions, yet still retain wildtype telomere length. Thus, the phenotype of this defect separates the two-telomere related phenotypes, capping and length maintenance. DNA-PKcs deficient MEFs also exhibit elevated levels of chromosome fragments and breaks, which correlate with increased telomere fusions. Based on the high levels of telomere fusions observed in DNA-PKcs deficient cells, we conclude that DNA-PKcs plays an important capping role at the mammalian telomere.

The soft lithography fabrication technique was applied to three microfluidic devices. The method was used to create an original micropump design and retrofit to existing designs for a DNA manipulation device and a counter biological warfare sample preparation device. Each device presented unique and original challenges to the soft lithography application. AI1 design constraints of the retrofit devices were satisfied using PDMS devices created through variation of soft lithography methods. The micropump utilized the versatility of PDMS, creating design options not available with other materials. In all cases, the rapid processing of soft lithography reduced the fabrication time, creating faster turnaround for design modifications.

LLNL has many in-house designed high precision machine tools. Some of these tools include the Large Optics Diamond Turning Machine (LODTM) [1], Diamond Turning Machine No.3 (DTM-3) and two Precision Engineering Research Lathes (PERL-I and PERL-II). These machines have accuracy in the sub-micron range and in most cases position resolution in the couple of nanometers range. All of these machines are built with similar underlying technologies. The machines use capstan drive technology, laser interferometer position feedback, tachometer velocity feedback, permanent magnet (PM) brush motors and analog velocity and position loop servo compensation [2]. The machine controller does not perform any servo compensation it simply computes the differences between the commanded position and the actual position (the following error) and sends this to a D/A for the analog servo position loop. LLNL is designing a new high precision diamond turning machine. The machine is called the ULTRA 350 [3]. In contrast to many of the proven technologies discussed above, the plan for the new machine is to use brushless linear motors, high precision linear scales, machine controller motor commutation and digital servo compensation for the velocity and position loops. Although none of these technologies are new and have been in use …

We review the current and future state of research in inertial fusion sciences. We describe the National Ignition Facility (NIF), the IFE development plan, applications of inertial confinement fusion (ICF) to various high-energy sciences, uses of petawatt laser systems, and concepts for the ICF integrated research experiment (IRE) and IFE power plants.

LLNL has many in-house designed high precision machine tools. Some of these tools include the Large Optics Diamond Turning Machine (LODTM) [1], Diamond Turning Machine No.3 (DTM-3) and two Precision Engineering Research Lathes (PERL-1 and PERL-11). These machines have accuracy in the sub-micron range and in most cases position resolution in the couple of nanometers range. All of these machines are built with similar underlying technologies. The machines use capstan drive technology, laser interferometer position feedback, tachometer velocity feedback, permanent magnet (PM) brush motors and analog velocity and position loop servo compensation [2]. The machine controller does not perform any servo compensation it simply computes the differences between the commanded position and the actual position (the following error) and sends this to a D/A for the analog servo position loop. LLNL is designing a new high precision diamond turning machine. The machine is called the ULTRA 350 [3]. In contrast to many of the proven technologies discussed above, the plan for the new machine is to use brushless linear motors, high precision linear scales, machine controller motor commutation and digital servo compensation for the velocity and position loops. Although none of these technologies are new and have been in use …

The USAF Integrated Flight Experiment (IFX) Project is part of the development of the Space Based Laser (SBL) Program. The LLNL Large Optics Diamond Turning Machine (LODTM) is responsible for diamond turning the aspheric laser cavity mirrors. These large optics must be manufactured to micro-inch tolerances. The optics are made of silicon to minimize cooling requirements and weight in the SBL. Diamond turning silicon presents many challenges to the LODTM; one of which is silicon's anisotropic property. When cutting these cones shaped optics, the machine sees many different crystallographic planes of the silicon. These planes present different degrees of material hardness. The tool is held in position but it experiences a force variation as it cuts across the different crystallographic planes. This force variation is reflected back into the machine control system and presents a dynamic disturbance that increases the servo system following error. The affect of this error is to cut a part that is not round but 'squareish', i.e. at the micro-inch level. Two methods were used to reduce the following error or increase the machine dynamic stiffness. Each method relies on the fact that the cutting process is cyclic. The two methods are described below. Method one …

Here I present some well known relationships that allow the variation in critical mass versus density to be written in a simple analytical form; these relationships have appeared extensively in the open literature for over 50 years, but seem to be periodically forgotten. These relationships are exact for bare, homogeneous systems, and approximate [but reasonably accurate] for reflected systems. With these relationships anyone can quickly estimate the critical mass corresponding to any given density, using nothing more complicated than a hand calculator.

Semiweekly newspaper from Boerne, Texas that includes local, state, and national news along with advertising.

Student newspaper of the University of Oklahoma in Norman, Oklahoma that includes national, local, and campus news along with advertising.

Daily newspaper from Baytown, Texas that includes local, state, and national news along with advertising.

Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.

Weekly newspaper from Emory, Texas that includes local, state, and national news along with advertising.

B-roll video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story about an interview with Angie Harmons.

Daily newspaper from Sapulpa, Oklahoma that includes local, state, and national news along with advertising.

There are many tools available to help diagnose equipment vibration problems around the Savannah River Site. With the advancement of technology surrounding vibration analysis, modal analysis, an old, proven engineering modeling technique, can now be performed using the multi-channel machinery analyzer found in most predictive maintenance programs. The use of modal analysis can help eliminate problems with plant equipment that include failure to maintain tolerances, noisy equipment operation, material failure, premature fatigue, and shorten equipment life. Mark H. Richardson of Vibrant Technology Inc., the creator of the MeScope Modal Analysis software program, defined modal analysis as the process of characterizing the dynamics of a structure in terms of its modes of vibration. Knowing the modes of vibration of a structure is useful information in itself, for it tells at what frequencies the structure can be excited into resonant motion, and the predominant wave-like motion it will assume at a resonant frequency.