This thesis is a study of 5-substituted-amino derivatives of 5-phenylhydantoin and anticonvulsant activity.

It has been shown in the case of a compound synthesized in this laboratory that substitution of the thienyl group for one of the phenyl groups in diphenyl hydantoin produces a compound with less toxicity and somewhat greater activity. It was considered of interest to carry out an analogous substitution in the series of 5-phenyl-5-alkoxymethylhydantions.

The project discussed in the paper consists of the substitution of another type of heterocycle, 2-tetrahydropyranyl, in position 5 of the hydantoin nucleus.

In view of the unexpected behavior of α-(benzenesulfonyl)-acetophenone toward hydrolysis and because of the possible physiological importance of its derivatives it was deemed of interest to make a further study of the hydrolysis of this compound. It was decided to study both the acid and basic hydrolysis of this compound. The problem consisted of finding a satisfactory means of analyzing the hydrolysis products, and carrying out the hydrolysis under the different conditions.

This study is about the mercury sensitized photochemical reactions of cyclohexane.

The acid which is analogous to the next member of the diphenylpolyenes, 1,4-diphenylbutadiene, is muconic acid. This acid has been chosen to be investigated in an effort to isolate all the stereoisomers of a set containing more than two isomers.

This thesis describes the creation of substituted diphenylacetic acids and their results.

Because of the structural analogies between these compounds and several other physiologically active compounds, such as chloroamphenicol, 4,4'-diaminodiphenyl sulfone, and 2,2-bis-(p-aminophenyl)-1,1,1-trichloroethane, a more complete study of the reduction products and the sequence of catalytic reduction of N-(4-nitrophenacyl)-4-(1-hexyl)pyridinium bromide was made in this investigation.

This study explores the synthesis and reduction of some n-phenacylpyridines and is an investigation of various derivatives.

The synthesis of several N-(4-nitrophenacyl)-4-alkylpyridinium halides and their reduction products, 1-(4-aminophenyl)-2-[1-(4-alkylpiperidyl)]ethanols, was undertaken because of structural analogies between these and other physiologically active compounds, such as chloroamphenicol (I), 4,4'-diaminodiphenyl sulfone (II), and 2,2-bis(p-aminophenyl)-1,1,1-trichloroethane (III).

This thesis describes the preparation of 5-substituted-amino derivatives of 5-phenylhydantoin. The hydantoin derivatives are to be tested for anticonvulsant activity by the Pharmacology Department of the Eli Lilly Company of Indianapolis, Indiana.

This study involves compounds of the barbituric acid series are well known for their use as anesthetics and sedatives.

It is the specific purpose of this investigation to determine the difference, if any, in the amount of practical, everyday chemistry learned by the science majors as opposed to the non-science majors enrolled in general chemistry at the North Texas State College during the school year 1950-1951.

This thesis describes experiments in creating derivatives of sulfonamide. The derivatives were then submitted for testing for anti-tubercular activity.

This thesis describes the process of synthesizing 5-substituted-mercapto derivatives of hydantoin in which the sulfur of the side chain is attached directly to the hydantoin nucleus.

This thesis describes the theoretical results of mercury-sensitized photochemical reactions of isopropyl benzene and methylcyclohexane. The reactions are carried out and the results are analyzed.

This paper is a study of the exchange of bismuth tetra-iodide and bismuth ions in an ion-precipitate system.

The purpose of this investigation is to study the polarographic characteristics of p-nitroacetophenone.

This work deals with the preparation of amine derivatives of 3-chloro-5(8?)-nitro-1,4-naphthoquinone which are to be tested for anti-tubercular activity by Parke, Davis and Company.

Since no mention has been found in the literature of any 5-substituted mercapto-5-alkyl derivatives of barbituric acid, it was thought to be of interest to prepare a series of compounds containing sulfur attached directly to the barbituric acid nucleus. 5-substituted mercapto-5-isoamylbarbituric acids were chosen as representative of barbituric acids in which the alkyl group has a fairly high molecular weight.

This thesis investigates nitrogen derivatives of naphthoquinone.

This study experiments with the methods of 1-(4, 4'-Dinitrodiphenylmethyl)-Piperidines; 1-(4-Nitrobenzyl)-and 1-(4-Nitrobenzoyl)-Piperdines.

This thesis discusses hydantoins as anticonvulsants. VII. 5-Substituted-aryloxy derivatives of 5-phenylhydantoin.

Since thiophene very often yields compounds that are analogous to benzene derivatives in general physiological properties, it was decided to attempt to prepare the nitro and amino derivatives of 1,1,1-trichloro-2,2-bis-(2-thienyl)-ethane (V) as well as the nitro and amino derivatives of 2,2,3-trichloro-1,1-bis-(2-thienyl)-butane (VI).