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Isorhamnetin Inhibits Proliferation and Invasion and Induces Apoptosis through the Modulation of Peroxisome Proliferator-activated Receptor γ Activation Pathway in Gastric Cancer
Article investigating the potential effects of isorhamnetin (IH), a 3′-O-methylated metabolite of quercetin on the peroxisome proliferator-activated receptor γ (PPAR-γ) signaling cascade using proteomics technology platform, GC cell lines, and xenograft mice model. The study y proposes a novel agent for gastric cancer treatment.
Date:
November 2, 2012
Creator:
Ramachandran, Lalitha; Manu, Kanjoormana Aryan; Shanmugam, Muthu K.; Li, Feng; Siveen, Kodappully Sivaraman; Vali, Shireen et al.
Object Type:
Article
System:
The UNT Digital Library
Low-temperature UV photoluminescence of ion beam synthesized Si nanoclusters embedded in Si
This article explores Ultraviolet (UV) photoluminescence (PL) data taken on a double Au implanted Si matrix and studied over a wide temperature range of 28-220K. The results of this study at lower temperatures indicate the emission to be coming from Si nanoclusters (NCs) embedded in the matrix.
Date:
April 3, 2012
Creator:
Sahu, G.; Lenka, H.P.; Mahapatra, Durga P.; Rout, B. & Das, M.P.
Object Type:
Article
System:
The UNT Digital Library
Cardiac and metabolic physiology of early larval zebrafish (Danio rerio) reflects parental swimming stamina
This article explores swimming stamina in fish. Mature adult zebrafish (Danio rerio) were subjected to a swimming performance test and then bred within performance groups to discover if enhanced swimming stamina in offspring appears only in juveniles/adults, or if these traits appear as early as larvae.
Date:
February 24, 2012
Creator:
Burggren, Warren W. & Gore, Matthew
Object Type:
Article
System:
The UNT Digital Library
Compartmentation of Triacylglycerol Accumulation in Plants
Article studying an underappreciated complexity in pathways for synthesis and accumulation of Triacylglycerols from plants, familiar to most people as vegetable oils.
Date:
January 20, 2012
Creator:
Chapman, Kent Dean & Ohlrogge, John B.
Object Type:
Article
System:
The UNT Digital Library
Coprologic survey of endoparasites from Darwin’s fox (Pseudalopex fulvipes) in Chiloé, Chile
Article on parasite presence in the critically endangered Darwin's fox (Pseudalopex fulvipes) in Chile. Parasites found include species and genera reported for the first time in Darwin's fox.
Date:
January 1, 2012
Creator:
Jiménez, Jaime E.; Briceño, C.; AlcaÃno, H.; Vásquez, P.; Funk, S. & González-Acuña, D.
Object Type:
Article
System:
The UNT Digital Library
Upper lethal temperatures of Northern Bobwhite embryos and the thermal properties of their eggs
This article explores the upper lethal temperature for Bobwhite eggs. Results find that thermal tolerances of Northern Bobwhite embryos are high, indicating an adaptation to the naturally occurring temperature extremes in the Bobwhite's environment. However, the results also indicate that high temperatures could have plausibly contributed to the population decline observed in the Bobwhite's semi-arid range.
Date:
January 1, 2012
Creator:
Reyna, Kelly S. & Burggren, Warren W.
Object Type:
Article
System:
The UNT Digital Library
Low-energy positron interactions with xenon
This article studies low-energy interactions of positrons with xenon experimentally and theoretically. Results are compared with previous literature.
Date:
December 8, 2011
Creator:
Machacek, J. R.; Makochekanwa, C.; Jones, A.C.L.; Caradonna, P.; Slaughter, D.S.; McEachran, R.P. et al.
Object Type:
Article
System:
The UNT Digital Library
Pulmonary compliance and lung volume varies with ecomorphology in anuran amphibians: implications for ventilatory-assisted lymph flux
This article examining the correlation between pulmonary compliance, lung volume, and lymph flux rates in anurans. The findings of this article suggest that lymph mobilization capacity may explain some of the variation in pulmonary compliance and lung volume in anurans.
Date:
October 1, 2011
Creator:
Hedrick, Michael; Hillman, Stanley S.; Drewes, Robert C. & Withers, Philip C.
Object Type:
Article
System:
The UNT Digital Library
Permutation Complexity Related to the Letter Doubling Map
Article presented at the 8th International Conference Words 2011 in Prague, Czech Republic. This article investigates the combinatorial complexity of infinite permutations on N associated with the image of uniformly recurrent aperiodic binary words under the letter doubling map.
Date:
August 17, 2011
Creator:
Widmer, Steven
Object Type:
Article
System:
The UNT Digital Library
Lipoxygenase-mediated Oxidation of Polyunsaturated N-Acylethanolamines in Arabidopsis
Article hypothesizing that lipoxygenase (LOX) participated in the metabolism of PU-NAEs through the formation of NAE-oxylipins. The data suggests that Arabidopsis LOXs indeed compete with FAAH to metabolize PU-NAEs during seedling establishment. Identification of endogenous amide-conjugated oxylipins suggests potential significance of these metabolites in vivo, and FAAH mutants may offer opportunities to address this in the future.
Date:
April 29, 2011
Creator:
Kilaru, Aruna; Herrfurth, Cornelia; Keereetaweep, Jantana; Hornung, Ellen; Venables, Barney J.; Feussner, Ivo et al.
Object Type:
Article
System:
The UNT Digital Library
Development of micro-electrode array based tests for neurotoxicity: assessment of interlaboratory reproducibility with neuroactive chemicals
Article evaluating the response to the pharmacological compounds Fluoxetine, Muscimol, and Verapamil in primary neuronal cultures. Final conclusions are drawn that MEA technology has a potential for standard in vitro neurotoxicity/neuropharmacology evaluation.
Date:
April 27, 2011
Creator:
Novellino, A.; Scelfo, Bibiana; Palosaari, T.; Price, A.; Sobanski, Tomasz; Shafer, T.J. et al.
Object Type:
Article
System:
The UNT Digital Library
Visualization of Lipid Droplet Composition by Direct Organelle Mass Spectrometry
Article reporting an approach that combines the visualization of individual lipid droplets (LDs), microphase extraction of lipid components from droplets, and the direct identification of lipid composition by nanospray mass spectrometry, even to the level of a single LD. The triacylglycerol (TAG) composition of LDs from several plant sources (mature cotton (Gossypium hirsutum) embryos, roots of cotton seedlings, and Arabidopsis thaliana seeds and leaves) were examined by direct organelle mass spectrometry and revealed the heterogeneity of LDs derived from different plant tissue sources.
Date:
February 4, 2011
Creator:
Horn, Patrick J.; Ledbetter, Nicole R.; James, Christopher N.; Hoffman, William D.; Case, Charlene R.; Verbeck, Guido F. et al.
Object Type:
Article
System:
The UNT Digital Library
Temperature-sensitive Post-translational Regulation of Plant Omega-3 Fatty-acid Desaturases Is Mediated by the Endoplasmic Reticulum-associated Degradation Pathway
Article expressing two closely related plant FAD3 genes in yeast cells and found that their enzymes produced significantly different amounts of omega-3 fatty acids and that these differences correlated to differences in rates of protein turnover. The findings indicate that Fad3 protein abundance is regulated by a combination of cis-acting degradation signals and the ubiquitin-proteasome pathway and that modulation of Fad3 protein amounts in response to temperature may represent one mechanism of homeoviscous adaptation in plants.
Date:
July 9, 2010
Creator:
O'Quin, Jami B.; Bourassa, Linda; Zhang, Daiyuan; Shockey, Jay M.; Gidda, Satinder K.; Fosnot, Spencer et al.
Object Type:
Article
System:
The UNT Digital Library
Frontiers in Aquatic Physiology – grand challenge
Opinion article covering grand challenges to aquatic physiology based on the five "grand challenges in organismal biology" proposed by Schwenk et al. (2007). This article also provides a list of specific examples of emerging areas of research interest in aquatic physiology.
Date:
May 18, 2010
Creator:
Evans, David H.; Axelsson, Michael; Beltz, Barbara; Burggren, Warren W.; Castellini, Michael; Clements, Kendall D. et al.
Object Type:
Article
System:
The UNT Digital Library
Mutations in Arabidopsis Fatty Acid Amide Hydrolase Reveal That Catalytic Activity Influences Growth but Not Sensitivity to Abscisic Acid or Pathogens
Article showing that the enhanced growth and NAE tolerance of the AtFAAH overexpressing seedlings depends on the catalytic activity of AtFAAH, hypersensitivity to ABA and hypersusceptibility to nonhost pathogens are independent of its enzymatic activity. Findings suggest that the AtFAAH influences plant growth and interacts with ABA signaling and plant defense through distinctly different mechanisms.
Date:
December 4, 2009
Creator:
Kim, Sang-Chul; Kang, Li; Nagaraj, Satish; Blancaflor, Elison B.; Mysore, Kirankumar S. & Chapman, Kent D.
Object Type:
Article
System:
The UNT Digital Library
Unraveling Δ1-Pyrroline-5-Carboxylate-Proline Cycle in Plants by Uncoupled Expression of Proline Oxidation Enzymes
Article showing that overexpression of MsProDH in tobacco and Arabidopsis or impairment of P5C oxidation in the Arabidopsis p5cdh mutant did not change the cellular Pro to P5C ratio under ambient and osmotic stress conditions, indicating that P5C excess was reduced to Pro in a mitochondrial-cytosolic cycle. Results show that normal oxidation of P5C to Glu by P5CDH is key to prevent P5C-Pro intensive cycling and avoid ROS production from electron run-off.
Date:
September 25, 2009
Creator:
Miller, Gad; Honig, Arik; Stein, Hanan; Suzuki, Nobuhiro; Mittler, Ron & Zilberstein, Aviah
Object Type:
Article
System:
The UNT Digital Library
Ascorbate Peroxidase 1 Plays a Key Role in the Response of Arabidopsis thaliana to Stress Combination
Article conducting proteomic and metabolic analysis of Arabidopsis thaliana plants subjected to a combination of drought and heat stress. The authors identify 45 different proteins that specifically accumulated in Arabidopsis in response to the stress combination. The findings suggest that cytosolic APX1 plays a key role in the acclimation of plants to a combination of drought and heat stress.
Date:
December 5, 2008
Creator:
Koussevitzky, Shai; Suzuki, Nobuhiro; Huntington, Serena; Armijo, Leigh; Sha, Wei; Cortes, Diego F. et al.
Object Type:
Article
System:
The UNT Digital Library
The Transcriptional Co-activator MBF1c Is a Key Regulator of Thermotolerance in Arabidopsis thaliana
Article reporting that the highly conserved transcriptional co-activator, MBF1c (multiprotein bridging factor 1c), is a key regulator of thermotolerance in Arabidopsis thaliana. Results provide evidence for the existence of a tightly coordinated heat stress-response network, involving trehalose-, SA-, and ethylene-signaling pathways, that is under the control of MBF1c.
Date:
April 4, 2008
Creator:
Suzuki, Nobuhiro; Bajad, Sunil; Shuman, Joel; Shulaev, Vladimir & Mittler, Ron
Object Type:
Article
System:
The UNT Digital Library
The EAR-motif of the Cys2/His2-type Zinc Finger Protein Zat7 Plays a Key Role in the Defense Response of Arabidopsis to Salinity Stress
Article reporting that transgenic Arabidopsis plants constitutively expressing the Cys2/His2 zinc finger protein Zat7 have suppressed growth and are more tolerant to salinity stress. Findings demonstrate that the EAR-domain of Cys2/His2-type zinc finger proteins plays a key role in the defense response of Arabidopsis to abiotic stresses.
Date:
March 23, 2007
Creator:
Ciftci-Yilmaz, Sultan; Morsy, Mustafa R.; Song, Luhua; Coutu, Alicia; Krizek, Beth A.; Lewis, Michael W. et al.
Object Type:
Article
System:
The UNT Digital Library
Function of Conserved Residues of Human Glutathione Synthetase: Implications for the ATP-Grasp Enzymes
Article examining the mechanism of Glutathione synthetase, an enzyme that belongs to the glutathione synthetase ATP-binding domain-like superfamily. A variety of structural alignment methods were applied and four highly conserved residues of human glutathione synthetase (Glu-144, Asn-146, Lys-305, and Lys-364) were identified in the binding site. The function of these was studied by experimental and computational site-directed mutagenesis.
Date:
May 21, 2004
Creator:
Dinescu, Adriana; Cundari, Thomas R., 1964-; Bhansali, Vikas S.; Luo, Jia-Li & Anderson, Mary E.
Object Type:
Article
System:
The UNT Digital Library
The Water-Water Cycle Is Essential for Chloroplast Protection in the Absence of Stress
Article showing that knockdown Arabidopsis plants with suppressed expression of the key water-water cycle enzyme, thylakoid-attached copper/zinc superoxide dismutase (KD-SOD), are suppressed in their growth and development. This article provides e genetic evidence for the importance of the water-water cycle in protecting the photosynthetic apparatus of higher plants from photooxidative damage.
Date:
October 3, 2003
Creator:
Rizhsky, Ludmila; Liang, Hongjian & Mittler, Ron
Object Type:
Article
System:
The UNT Digital Library
Phosphorylation of Myosin Light Chain Kinase by p21-activated Kinase PAK2
Article reporting that PAK2, a member of the Rho family of GTPase-dependent kinases, regulates isometric tension development and myosin II RLC phosphorylation in saponin permeabilized endothelial monolayers. The results demonstrate that PAK2 can directly phosphorylate MLCK, inhibiting its activity and limiting the development of isometric tension.
Date:
June 16, 2000
Creator:
Goeckeler, Zoe M.; Masaracchia, Ruthann A.; Zeng, Qi; Chew, Teng-Leong; Gallagher, Patricia & Wysolmerski, Robert B.
Object Type:
Article
System:
The UNT Digital Library
Activation of an S6/H4 Kinase (PAK 65) from Human Placenta by Intramolecular and Intermolecular Autophosphorylation
Article proposing a model in which phosphorylation of sites 1 and 2 occurs sequentially. The model proposes that trypsin treatment of the inactive holoenzyme removes an inhibitory rac-binding domain which blocks MgATP access to the catalytic site. The pseudosubstrate domain at site 1 is autophosphorylated and subsequent bimolecular autophosphorylation at site 2 fully opens the catalytic site.
Date:
September 8, 1995
Creator:
Benner, Gretchen E.; Dennis, Patrick B. & Masaracchia, Ruthann A.
Object Type:
Article
System:
The UNT Digital Library
Activation of an S6 Kinase From Human Placenta by Autophosphorylation
Article describing a novel S6 kinase isolated from human placenta which autoactivates through autophosphorylation in vitro. The data supports the hypothesis that this previously uncharacterized S6 kinase belongs to a unique family of protein kinases which utilize autophosphorylation as part of their in vivo activation mechanism.
Date:
September 15, 1993
Creator:
Dennis, Patrick B. & Masaracchia, Ruthann A.
Object Type:
Article
System:
The UNT Digital Library