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Gene-based association tests using GWAS summary statistics and incorporating eQTL
Article proposes a powerful and computationally efficient gene-based association test, called Overall. Using extended Simes procedure, Overall aggregates information from three types of traditional gene-based association tests and also incorporates expression quantitative trait locus (eQTL) information into a gene-based association test using GWAS summary statistics. The results show that this newly developed method can identify more significant genes than other methods.
Date:
March 3, 2022
Creator:
Cao, Xuwei; Wang, Xuexia; Zhang, Shuanglin & Sha, Qiuying
System:
The UNT Digital Library