Resource Type

States

Neighborhood Price Externalities of Foreclosure Rehabilitation: An Examination of the Neighborhood Stabilization Program

This article examines the neighborhood price impacts of Neighborhood Stabilization Program (NSP) funded foreclosure rehabilitation undertaken by Habitat for Humanity in Dallas County, Texas using a difference-in-difference framework.
Date: January 12, 2017
Creator: Leonard, Tammy; Jha, Nikhil & Zhang, Lei
System: The UNT Digital Library
A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma (open access)

A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma

This study further explores a prior screening program carried out using MTT assay that identified a series of novel benzimidazole derivatives, among which Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) showed highest anticancer efficacy compared to that of chemotherapeutic agent, cisplatin. In this article, the authors find that MBIC inhibited cell viability in different hepatocellular carcinoma (HCC) cell lines without exerting significant cytotoxic effects on normal liver cells. The results of this study demonstrate that MBIC may inhibit cell proliferation via ROS-mediated activation of the JNK signaling cascade in HCC cells.
Date: January 12, 2017
Creator: Dai, Xiaoyun; Wang, Ling Zhi; Deivasigamni, Amudha; Looi, Chung Yeng; Karthikeyan, Chandrabose; Trivedi, Piyush et al.
System: The UNT Digital Library