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Development of Biodegradable Nanocarriers Loaded with a Monoclonal Antibody
This article examines the feasibility of encapsulating monoclonal antibodies within poly(lactic-co-glycolic acid) (PLGA) nanoparticles using a water/oil/water double emulsion solvent evaporation technique. This method can be used to prepare protective polymeric nanoparticles for transporting functional antibodies to the cytoplasmic compartment of cancer cells. The author's studies achieved successful formulation of antibody loaded polymeric nanoparticles, thus indicating that a PLGA-based antibody nanoformulation is a promising intracellular delivery vehicle for a large number of new intracellular antibody targets in cancer cells.
Date:
February 12, 2015
Creator:
Gdowski, Andrew; Ranjan, Amalendu; Mukerjee, Anindita & Vishwanatha, Jamboor
System:
The UNT Digital Library
Nanoparticle Effects on Human Platelets in Vitro: A Comparison between PAMAM and Triazine Dendrimers
The article looks at Triazine and PAMAM dendrimers of similar size and number of cationic surface groups and compared them for their ability to promote platelet aggregation.
Date:
March 29, 2016
Creator:
Enciso, Alan E.; Neun, Barry; Rodriguez, Jamie & Ranjan, Amalendu P.
System:
The UNT Digital Library
The Multifunctional Protein Kinase C-ε in Cancer Development and Progression
Paper focuses on the role of protein kinase C in different processes that lead to cancer development and progression.
Date:
April 10, 2014
Creator:
Jain, Kirti & Basu, Alakananda
System:
The UNT Digital Library