Hidden Markov model-based activity recognition for toddlers (open access)

Hidden Markov model-based activity recognition for toddlers

Article describes study which sought to evaluate methods for activity recognition for toddlers.
Date: March 5, 2020
Creator: Albert, Mark; Sugianto, Albert; Nickele, Katherine; Zavos, Patricia; Sindu, Pinky; Ali, Munazza et al.
System: The UNT Digital Library
Wearable airbag technology and machine learned models to mitigate falls after stroke (open access)

Wearable airbag technology and machine learned models to mitigate falls after stroke

Article discusses wearable airbag technology that has been designed to detect and mitigate fall impact. However, this technology has not been validated for the stroke population, so authors investigated whether population-specific training data and modeling parameters are required to pre-detect falls in a chronic stroke population.
Date: June 17, 2022
Creator: Botonis, Olivia K.; Harari, Yaar; Embry, Kyle R.; Mummidisetty, Chaithanya K.; Riopelle, David; Giffhorn, Matt et al.
System: The UNT Digital Library
Differential Responses of Transplanted Stem Cells to Diseased Environment Unveiled by a Molecular NIR-II Cell Tracker (open access)

Differential Responses of Transplanted Stem Cells to Diseased Environment Unveiled by a Molecular NIR-II Cell Tracker

This article develops a molecular cell tracker with a strong fluorescence signal in the second near-infrared (NIR-II) window (1,000-1,700 nm) for real-time monitoring of in vivo cell behaviors in both healthy and diseased animal models to address the issue of precisely and quantitatively evaluating the in vivo cell distribution, migration, and engraftment in stem cell therapy.
Date: June 9, 2021
Creator: Chen, Hao; Yang, Huaxiao; Zhang, Chen; Chen, Si; Zhao, Xin; Zhu, Mark et al.
System: The UNT Digital Library
Detergent-Based Decellularization for Anisotropic Cardiac-Specific Extracellular Matrix Scaffold Generation (open access)

Detergent-Based Decellularization for Anisotropic Cardiac-Specific Extracellular Matrix Scaffold Generation

Article describes how cell-derived extracellular matrix has become increasingly popular in tissue engineering applications due to its ability to provide tailored signals for desirable cellular responses. The objective of this study was to assess the efficacy of two detergent-based decellularization methods: a combination of ethylenediaminetetraacetic acid and sodium dodecyl sulfate and a combination of sodium deoxycholate and deoxyribonuclease.
Date: November 17, 2023
Creator: Chen, Te-An; Sharma, Dhavan; Jia, Wenkai; Ha, Donggi; Man, Kun; Zhang, Jianhua et al.
System: The UNT Digital Library
Flexible and Stretchable Bioelectronics (open access)

Flexible and Stretchable Bioelectronics

Article reviewing several several flexible and stretchable materials used as substrate, stretchable electrical conduits and encapsulation, design modifications for stretchability, fabrication techniques, methods of signal transmission and monitoring, and the power sources for these stretchable bioelectronics. Ultimately, these bioelectronic devices can be used for wide range of applications from skin bioelectronics and biosensing devices, to neural implants for diagnostic or therapeutic purposes.
Date: December 20, 2021
Creator: Chitrakar, Chandani; Hedrick, Eric; Adegoke, Lauren & Ecker, Melanie
System: The UNT Digital Library
Multifaceted Shape Memory Polymer Technology for Biomedical Application: Combining Self-Softening and Stretchability Properties (open access)

Multifaceted Shape Memory Polymer Technology for Biomedical Application: Combining Self-Softening and Stretchability Properties

Article describes how thiol-ene polymers are a promising class of biomaterials with a wide range of potential applications, including organs-on-a-chip, microfluidics, drug delivery, and wound healing. This study investigated the incorporation of di-acrylate chain extenders to improve the stretchability and conformability of those flexible thiol-ene polymers.
Date: October 25, 2023
Creator: Chitrakar, Chandani; Torres, Marc Anthony; Rocha-Flores, Pedro Emanuel; Hu, Qichan & Ecker, Melanie
System: The UNT Digital Library
On-chip multiplexed single-cell patterning and controllable intracellular delivery (open access)

On-chip multiplexed single-cell patterning and controllable intracellular delivery

Article presents a simple 3D electroporation platform that enables massively parallel single-cell manipulation and the intracellular delivery of macromolecules and small molecules.
Date: February 24, 2020
Creator: Dong, Zaizai; Jiao, Yanli; Xie, Bingteng; Hao, Yongcun; Wang, Pan; Liu, Yuanyuan et al.
System: The UNT Digital Library
Review of Colonic Anastomotic Leakage and Prevention Methods (open access)

Review of Colonic Anastomotic Leakage and Prevention Methods

This article presents a composite review involving some of the current and best treatments for colonic anastomotic leakage that are available in order to better understand the steps taken to treat this complication.
Date: November 3, 2020
Creator: Fang, Alex H.; Chao, Wilson & Ecker, Melanie
System: The UNT Digital Library
Deep learning for peptide identification from metaproteomics datasets (open access)

Deep learning for peptide identification from metaproteomics datasets

This article explores a proposed deep-learning-based algorithm called DeepFilter for improving peptide identifications from a collection of tandem mass spectra. The authors find that DeepFilter is believed to generalize properly to new, previously unseen peptide-spectrum-matches and can be readily applied in peptide identification from metaproteomics data.
Date: July 8, 2021
Creator: Feng, Shichao; Sterzenbach, Ryan & Guo, Xuan
System: The UNT Digital Library
Mesenchymal stem cells aligned and stretched in self-assembling peptide hydrogels (open access)

Mesenchymal stem cells aligned and stretched in self-assembling peptide hydrogels

Article describes how the presented research highlights a novel approach using fmoc-protected peptide hydrogels for the encapsulation and stretching of mesenchymal stem cells. This study utilized a custom mechanical stretching device with a PDMS chamber to stretch human mesenchymal stem cells encapsulated in Fmoc hydrogels.
Date: December 19, 2023
Creator: Fouladgar, Farzaneh; Moslabeh, Forough G. Z.; Kasani, Yashesh V.; Rogozinski, Nick; Torres, Marc; Ecker, Melanie et al.
System: The UNT Digital Library
Decellularization Strategies for Regenerative Medicine: From Processing Techniques to Applications (open access)

Decellularization Strategies for Regenerative Medicine: From Processing Techniques to Applications

This review compares the advantages and disadvantages of decellularization methods in terms of their ability to retain desired extracellular matrix characteristics for particular tissues and organs.
Date: April 30, 2017
Creator: Gilpin, Anna & Yang, Yong
System: The UNT Digital Library
A Review of Rehabilitative and Assistive Technologies for Upper-Body Exoskeletal Devices (open access)

A Review of Rehabilitative and Assistive Technologies for Upper-Body Exoskeletal Devices

Authors state that this journal review article focuses on the use of assistive and rehabilitative exoskeletons as a new opportunity for individuals with diminished mobility. Overall, this article serves as a valuable resource for individuals working in the field of assistive and rehabilitative exoskeletons, providing insight into the state of the art and potential areas for improvement.
Date: April 20, 2023
Creator: Hays, Emilly; Slayton, Jack; Tejeda-Godinez, Gary; Carney, Emily; Cruz, Kobe; Exley, Trevor et al.
System: The UNT Digital Library
In-vitro biomineralization and biocompatibility of friction stir additively manufactured AZ31B magnesium alloy-hydroxyapatite composites (open access)

In-vitro biomineralization and biocompatibility of friction stir additively manufactured AZ31B magnesium alloy-hydroxyapatite composites

Article presents research where friction stir additive manufacturing technique was employed to fabricate AZ31B magnesium-hydroxyapatite composite. The study aims to evaluate effect of hydroxyapatite (HA, Ca₁₀(PO₄)₆OH₂), a ceramic similar to natural bone, into AZ31B Mg alloy matrix on biomineralization and biocompatibility.
Date: June 30, 2020
Creator: Ho, Yee-Hsien; Man, Kun; Joshi, Sameehan; Pantawane, Mangesh V.; Wu, Tso-Chang; Yang, Yong et al.
System: The UNT Digital Library
Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis (open access)

Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis

This article is a review that illustrates the involvement of MMP-13 in the initiation and progression of Osteoarthritis (OA) through the regulation of MMP-13 activity at the molecular and epigenetic levels, as well as the strategies that have been employed against MMP-13. The aim of this review is to identify MMP-13 as an attractive target for inhibitor development in the treatment of OA.
Date: February 9, 2021
Creator: Hu, Qichan & Ecker, Melanie
System: The UNT Digital Library
Bioengineering Systems for Modulating Notch Signaling in Cardiovascular Development, Disease, and Regeneration (open access)

Bioengineering Systems for Modulating Notch Signaling in Cardiovascular Development, Disease, and Regeneration

This article is a review summarizing the significant roles of Notch signaling in individual cardiac cell types. It covers the bioengineering systems of microfluidics, hydrogel, spheroid, and 3D bioprinting and provides insights into ancillary supports of bioengineering systems, varied types of cardiovascular cells, and advanced characterization approaches in further refining Notch signaling in cardiovascular development, disease, and regeneration.
Date: September 30, 2021
Creator: Huerta Gomez, Angello; Joshi, Sanika; Yang, Yong; Tune, Johnathan D. & Zhao, Ming-Tao
System: The UNT Digital Library
Preface: International Conference on Recent Advancements in Biomedical Engineering - 2021 (open access)

Preface: International Conference on Recent Advancements in Biomedical Engineering - 2021

This article showcasing the editorial team welcomes all readers to the proceedings of International Conference on Recent Advancements in Biomedical Engineering (ICRABE-2021). The conference was inspired by the fusion of science and engineering principles in healthcare services and products. The conference aims to initiate exchange of innovative ideas between students, research scholar and faculties. Specifically, mechanical principles, power control for medical devices, nanomaterials and associated technologies were focused. This proceeding comprises of a broad spectrum of techniques to expose the recent advancements in the field of physics for healthcare application. A List of the Organizing Committee, Advisory Committee, Technical Committee are available in the pdf.
Date: 2021
Creator: International Conference on Recent Advancements in Biomedical Engineering
System: The UNT Digital Library
Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes (open access)

Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes

Article develops vertically-aligned nanocrown electrodes that are mechanically robust and achieve > 99% success rates in obtaining intracellular access through electroporation. This technology development provides an advancement towards establishing an iAP screening assay for preclinical evaluation of drug-induced arrhythmogenicity.
Date: April 26, 2022
Creator: Jahed, Zeinab; Yang, Yang; Tsai, Ching-Ting; Foster, Ethan P.; McGuire, Allister F.; Yang, Huaxiao et al.
System: The UNT Digital Library
Using a microprocessor knee (C-Leg) with appropriate foot transitioned individuals with dysvascular transfemoral amputations to higher performance levels: a longitudinal randomized clinical trial (open access)

Using a microprocessor knee (C-Leg) with appropriate foot transitioned individuals with dysvascular transfemoral amputations to higher performance levels: a longitudinal randomized clinical trial

Article evaluating whether advanced prostheses can provide better safety and performance capabilities to maintain and improve quality of life in individuals who are predominantly designated MFCL level K2. This study used a 13 month longitudinal clinical trial to determine the benefits of using a C-Leg and 1M10 foot in individuals at K2 level with transfemoral amputation due to vascular disease.
Date: May 25, 2021
Creator: Jayaraman, Chandrasekaran; Mummidisetty, Chaithanya K.; Albert, Mark; Lipschutz, Robert; Hoppe-Ludwig, Shenan; Mathur, Gayatri et al.
System: The UNT Digital Library
Suppression of the antitumoral activity of natural killer cells under indirect coculture with cancer-associated fibroblasts in a pancreatic TIME-on-chip model (open access)

Suppression of the antitumoral activity of natural killer cells under indirect coculture with cancer-associated fibroblasts in a pancreatic TIME-on-chip model

Article describes how recently, natural killer cells emerged as a treatment option for various solid tumors. The effect of activated pancreatic stellate cells on natural killer cell-mediated anticancer efficacy under three-dimensional coculture conditions was investigated.
Date: September 27, 2023
Creator: Kim, Hyun-Ah; Kim, Hyunsoo; Nam, Min-Kyung; Park, Jong Kook; Lee, Moo-Yeal; Chung, Seok et al.
System: The UNT Digital Library
Potential Toxicity and Underlying Mechanisms Associated with Pulmonary Exposure to Iron Oxide Nanoparticles: Conflicting Literature and Unclear Risk (open access)

Potential Toxicity and Underlying Mechanisms Associated with Pulmonary Exposure to Iron Oxide Nanoparticles: Conflicting Literature and Unclear Risk

This review article will focus on known risks following iron oxide nanoparticles (IONPs) exposure supported by human, animal, and cell culture-based studies, the potential challenges intrinsic to IONPs toxicity assessment, and how these may contribute to the poorly characterized IONPs toxicity profile.
Date: September 7, 2017
Creator: Kornberg, Tiffany G.; Stueckle, Todd A.; Antonini, James M.; Rojanasakul, Liying W.; Castranova, Vincent; Yang, Yong et al.
System: The UNT Digital Library
Hedgehog signaling is involved in acquired resistance to KRASG12C inhibitors in lung cancer cells (open access)

Hedgehog signaling is involved in acquired resistance to KRASG12C inhibitors in lung cancer cells

Article states that although KRASG12C inhibitors have shown promising activity in lung adenocarcinomas harboring KRASG12C, acquired resistance to these therapies eventually occurs in most patients. The authors report that the hedgehog signal is induced by KRASG12C inhibitors and mediates KRAS re-expression in cancer cells treated with a KRASG12C inhibitor.
Date: January 16, 2024
Creator: Lee, Chaeyoung; Yi, Jawoon; Park, Jihwan; Ahn, Byungyong; Won, Young-Wook; Jeon, JiHeung et al.
System: The UNT Digital Library
PP2Cδ inhibits p300-mediated p53 acetylation via ATM/BRCA1 pathway to impede DNA damage response in breast cancer (open access)

PP2Cδ inhibits p300-mediated p53 acetylation via ATM/BRCA1 pathway to impede DNA damage response in breast cancer

Article describes study which indicates that nuclear type 2C protein phosphatase (PP2Cδ) impairs p53 acetylation and DNA damage response by compromising BRCA1 function in breast cancer development.
Date: October 16, 2019
Creator: Li, Qun; Hao, Qiongyu; Cao, Wei; Li, Jieqing; Wu, Ke; Elshimali, Yahya et al.
System: The UNT Digital Library
A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations (open access)

A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations

Article suggests that common standards for recording, detection, and reporting for intracranial recordings in humans that suggest their role in episodic and semantic memory does not exist. Authors of the article outline the methodological challenges involved in detecting ripple events and offer practical recommendations to improve separation from other high-frequency oscillations, and argue that shared experimental, detection, and reporting standards will provide a solid foundation for future translational discovery.
Date: October 12, 2022
Creator: Liu, Anli A.; Henin, Simon; Abbaspoor, Saman; Bragin, Anatol; Buffalo, Elizabeth A.; Farrell, Jordan S. et al.
System: The UNT Digital Library
Bioabsorbable zinc ion induced biphasic cellular responses in vascular smooth muscle cells (open access)

Bioabsorbable zinc ion induced biphasic cellular responses in vascular smooth muscle cells

This article explores the short-term effects of extracellular Zn²⁺ on human smooth muscle cells.
Date: January 6, 2016
Creator: Ma, Jun; Zhao, Nan & Zhu, Donghui
System: The UNT Digital Library