A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma (open access)

A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma

This study further explores a prior screening program carried out using MTT assay that identified a series of novel benzimidazole derivatives, among which Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) showed highest anticancer efficacy compared to that of chemotherapeutic agent, cisplatin. In this article, the authors find that MBIC inhibited cell viability in different hepatocellular carcinoma (HCC) cell lines without exerting significant cytotoxic effects on normal liver cells. The results of this study demonstrate that MBIC may inhibit cell proliferation via ROS-mediated activation of the JNK signaling cascade in HCC cells.
Date: January 12, 2017
Creator: Dai, Xiaoyun; Wang, Ling Zhi; Deivasigamni, Amudha; Looi, Chung Yeng; Karthikeyan, Chandrabose; Trivedi, Piyush et al.
Object Type: Article
System: The UNT Digital Library
Environmental vibrios represent a source of antagonistic compounds that inhibit pathogenic Vibrio cholerae and Vibrio parahaemolyticus strains (open access)

Environmental vibrios represent a source of antagonistic compounds that inhibit pathogenic Vibrio cholerae and Vibrio parahaemolyticus strains

This article predicts that marine-derived bacteria should inhibit Vibrio pathogens and may be a source of unique antibiotic compounds.
Date: March 10, 2017
Creator: Burks, David J.; Norris, Stephen; Kauffman, Kathryn M.; Joy, Abigail; Arevalo, Philip; Azad, Rajeev K. et al.
Object Type: Article
System: The UNT Digital Library
Brassinosteroid Mediated Cell Wall Remodeling in Grasses Under Abiotic Stress (open access)

Brassinosteroid Mediated Cell Wall Remodeling in Grasses Under Abiotic Stress

This article focuses on recent advances in brassinosteroid-regulated cell wall biosynthesis and remodeling in response to stresses, comparing the authors' understanding of the mechanisms in grass species with those in the more studied dicots.
Date: May 17, 2017
Creator: Rao, Xiaolan & Dixon, R. A.
Object Type: Article
System: The UNT Digital Library
Genetically engineered probiotic for the treatment of phenylketonuria (PKU); assessment of a novel treatment in vitro and in the PAHᵉⁿᵘ² mouse model of PKU (open access)

Genetically engineered probiotic for the treatment of phenylketonuria (PKU); assessment of a novel treatment in vitro and in the PAHᵉⁿᵘ² mouse model of PKU

This article describes the testing of a phenylalanine lyase gene from Anabaena variabilis (AvPAL) codon-optimized and cloned into a shuttle vector for expression in Lactobacillus reuteri 100-23C (pHENOMMenal).
Date: May 17, 2017
Creator: Durrer, Katherine E.; Allen, Michael S. & Hunt von Herbing, Ione
Object Type: Article
System: The UNT Digital Library
Cardiorespiratory physiological phenotypic plasticity in developing air-breathing anabantid fishes (Betta splendens and Trichopodus trichopterus) (open access)

Cardiorespiratory physiological phenotypic plasticity in developing air-breathing anabantid fishes (Betta splendens and Trichopodus trichopterus)

This article discusses development plasticity of cardiorespiratory physiology in two air-breathing anabantid fishes.
Date: June 16, 2017
Creator: Mendez-Sanchez, Jose F. & Burggren, Warren W.
Object Type: Article
System: The UNT Digital Library
Gold at what cost? Another megaproject threatens biodiversity in the Amazon (open access)

Gold at what cost? Another megaproject threatens biodiversity in the Amazon

Article discusses concerns and controversy related to the gold mining ‘Volta Grande Project’ at the Xingu River in northern Brazil.
Date: June 26, 2017
Creator: Tófoli, Raffael M.; Dias, Rosa M.; Alves, Gustavo H. Zaia; Hoeinghaus, David J.; Gomes, Luiz C.; Baumgartner, Matheus T. et al.
Object Type: Article
System: The UNT Digital Library
Gold at What Cost? Another Megaproject Threatens Biodiversity in the Amazon (open access)

Gold at What Cost? Another Megaproject Threatens Biodiversity in the Amazon

This article summarizes three controversial aspects of the Volta Grande project.
Date: March 24, 2017
Creator: Tófoli, Raffael M.; Dias, Rosa M.; Alves, Gustavo H. Zaia; Hoeinghaus, David; Gomes, Luiz C.; Baumgartner, Matheus T. et al.
Object Type: Article
System: The UNT Digital Library
Heart Performance Determination by Visualization in Larval Fishes: Influence of Alternative Models for Heart Shape and Volume (open access)

Heart Performance Determination by Visualization in Larval Fishes: Influence of Alternative Models for Heart Shape and Volume

This article assesses the validity of three different heart models applied to digital images of complete cardiac cycles in larval mahi-mahi and red drum.
Date: July 4, 2017
Creator: Perrichon, Prescilla; Grosell, Martin & Burggren, Warren W.
Object Type: Article
System: The UNT Digital Library
Developmental Transcriptomic Analyses for Mechanistic Insights Into Critical Pathways Involved in Embryogenesis of Pelagic Mahi-Mahi (Coryphaena Hippurus) (open access)

Developmental Transcriptomic Analyses for Mechanistic Insights Into Critical Pathways Involved in Embryogenesis of Pelagic Mahi-Mahi (Coryphaena Hippurus)

This article characterizes the developmental transcriptome of mahi-mahi by means of high throughput sequencing at three critical developmental stages.
Date: July 10, 2017
Creator: Xu, Elvis Genbo; Mager, Edward M.; Grosell, Martin; Stieglitz, John D.; Hazard, E. Starr; Hardiman, Gary et al.
Object Type: Article
System: The UNT Digital Library
Art therapy and music reminiscence activity in the prevention of cognitive decline: study protocol for a randomized controlled trial (open access)

Art therapy and music reminiscence activity in the prevention of cognitive decline: study protocol for a randomized controlled trial

This article explores the feasibility of using art therapy and music reminiscence activity to improve the cognition of community living elderly with mild cognitive impairment.
Date: July 12, 2017
Creator: Mahendran, Rathi; Rawtaer, Iris; Fam, Johnson; Wong, Jonathan; Kumar, Alan Prem; Gandhi, Mihir et al.
Object Type: Article
System: The UNT Digital Library
Genome Sequences of Five Streptomyces Bacteriophages Forming Cluster BG (open access)

Genome Sequences of Five Streptomyces Bacteriophages Forming Cluster BG

This article discusses the isolation of five novel phages, which were used to established the cluster BF, using Streptomyces griseus subsp. griseus strain ATcC 10137 as the host.
Date: July 13, 2017
Creator: Donegan-Quick, Richard; Gibbs, Zane A.; Amaku, Patricia O.; Bernal, Joshua T.; Boyd, Dana A. M.; Burr, Angela R. et al.
Object Type: Article
System: The UNT Digital Library
Association between CYP2D6 Genotypes and the Risk of Antidepressant Discontinuation, Dosage Modification and the Occurrence of Maternal Depression during Pregnancy (open access)

Association between CYP2D6 Genotypes and the Risk of Antidepressant Discontinuation, Dosage Modification and the Occurrence of Maternal Depression during Pregnancy

This article investigates the association between CYP2D6 genotype and the risk of antidepressant discontinuation, dosage modification, and the occurrence of maternal CYP2D6, Antidepressants, Depression during pregnancy.
Date: July 17, 2017
Creator: Bérard, Anick; Gaedigk, Andrea; Sheehy, Odile; Chambers, Christina; Roth, Mark; Bozzo, Pina et al.
Object Type: Article
System: The UNT Digital Library
Tales of diversity: Genomic and morphological characteristics of forty-six Arthrobacter phages (open access)

Tales of diversity: Genomic and morphological characteristics of forty-six Arthrobacter phages

This article describes the isolation and genomic characterization of 46 phages from environmental samples at various geographic locations in the U.S. infecting a single Arthrobacter sp. strain.
Date: July 17, 2017
Creator: Klyczek, Karen; Bonilla, J. Alfred; Jacobs-Sera, Deborah; Adair, Tamarah; Afram, Patricia; Allen, Katherine G. et al.
Object Type: Article
System: The UNT Digital Library
A Brief History of Insecticides and Quail (open access)

A Brief History of Insecticides and Quail

This paper examines the types of insecticides that have been used in the United States, how quail could be exposed to these substances, and how they may have contributed to declining quail populations.
Date: July 25, 2017
Creator: Gobeli, Amanda; Thompson, Caitlin & Reyna, Kelly S.
Object Type: Paper
System: The UNT Digital Library
An Evaluation of Northern Bobwhite Conservation Research: A Call for Large-Scale Studies (open access)

An Evaluation of Northern Bobwhite Conservation Research: A Call for Large-Scale Studies

This paper reviews current and historical studies that have facilitated the implementation of management techniques on multiple scales.
Date: July 25, 2017
Creator: Gomez, Lex J. & Reyna, Kelly S.
Object Type: Paper
System: The UNT Digital Library
Predicting Northern Bobwhite Habitat in Semiarid Rangeland Using LANDSAT Imagery (open access)

Predicting Northern Bobwhite Habitat in Semiarid Rangeland Using LANDSAT Imagery

This paper discusses a classification on 4 LANDSAT scenes of Clay County, Texas, from July and December 2015 to identify bobwhite habitat in subhumid and semiarid rangeland.
Date: July 25, 2017
Creator: Whitt, Jeffrey G. & Reyna, Kelly S.
Object Type: Paper
System: The UNT Digital Library
Retention and Efficacy of Citizen Scientist Volunteers of the Texas Quail Index (open access)

Retention and Efficacy of Citizen Scientist Volunteers of the Texas Quail Index

This paper discusses volunteer retention and efficacy for the Texas Quail Index.
Date: July 25, 2017
Creator: Reyna, Kelly S. & Rollins, Dale
Object Type: Paper
System: The UNT Digital Library
Translocation as a Population Restoration Technique for Northern Bobwhites: A Review and Synthesis (open access)

Translocation as a Population Restoration Technique for Northern Bobwhites: A Review and Synthesis

This paper includes a review and recommendation by the National Bobwhite Technical Committee Science Subcommittee, along with a discussion of the state of science on key aspects of bobwhite conservation, best management practices for translocation, and ways to reduce uncertainty about implementation.
Date: July 25, 2017
Creator: Martin, James A.; Applegate, Roger D.; Dailey, Thomas V.; Downey, Michelle; Emmerich, Beth; Hernández, Fidel et al.
Object Type: Paper
System: The UNT Digital Library
Tailoring seed oil composition in the real world: optimising omega-3 long chain polyunsaturated fatty acid accumulation in transgenic Camelina sativa (open access)

Tailoring seed oil composition in the real world: optimising omega-3 long chain polyunsaturated fatty acid accumulation in transgenic Camelina sativa

This article discusses the further tailoring of the seed oil profile to reduce the omega-6 content, and an evaluation of the performance of such GM plants under field conditions in terms of agronomic performance and the lipidomic profile of seed oil.
Date: July 26, 2017
Creator: Usher, Sarah; Han, Lihua; Haslam, Richard P.; Michaelson, Louise V.; Sturtevant, Drew; Aziz, Mina et al.
Object Type: Article
System: The UNT Digital Library
Extensive shared polymorphism at non-MHC immune genes in recently diverged North American prairie grouse (open access)

Extensive shared polymorphism at non-MHC immune genes in recently diverged North American prairie grouse

This article investigates the patterns of shared polymorphism and selection at non-MHC immune genes in five grouse species from Centrocercus and Tympanuchus genera.
Date: August 2, 2017
Creator: Minias, Piotr; Bateson, Zachary W.; Whittingham, Linda A.; Johnson, Jeff A.; Oyler-McCance, Sara & Dunn, Peter O.
Object Type: Article
System: The UNT Digital Library
An Updated Understanding of Texas Bumble Bee (Hymenoptera: Apidae) Species Presence and Potential Distributions in Texas, Usa (open access)

An Updated Understanding of Texas Bumble Bee (Hymenoptera: Apidae) Species Presence and Potential Distributions in Texas, Usa

This article aims to update existing Texas bumble bee presence databases, model statewide species distributions, and identify conservation target areas.
Date: August 10, 2017
Creator: Beckham, Jessica L. & Atkinson, Samuel F.
Object Type: Article
System: The UNT Digital Library
Epigenetic reprogramming converts human Wharton's jelly mesenchymal stem cells into functional cardiomyocytes by differential regulation of Wnt mediators (open access)

Epigenetic reprogramming converts human Wharton's jelly mesenchymal stem cells into functional cardiomyocytes by differential regulation of Wnt mediators

This article studies the differentiation of human Wharton's jelly mesenchymal stem cells into the cardiomyocyte lineage via epigenetic manipulations.
Date: May 24, 2017
Creator: Bhuvanalakshmi, G.; Arfuso, Frank; Kumar, Alan Prem; Dharmarajan, Arunasalam & Warrier, Sudha R.
Object Type: Article
System: The UNT Digital Library
Oral Spore-Based Probiotic Supplementation Was Associated With Reduced Incidence of Post-Prandial Dietary Endotoxin, Triglycerides, and Disease Risk Biomarkers (open access)

Oral Spore-Based Probiotic Supplementation Was Associated With Reduced Incidence of Post-Prandial Dietary Endotoxin, Triglycerides, and Disease Risk Biomarkers

This article contains a study to determine if 30-d of oral spore-based probiotic supplementation could reduce dietary endotoxemia.
Date: January 26, 2017
Creator: McFarlin, Brian K.; Henning, Andrea L.; Bowman, Erin M.; Gary, Melody A. & Carbajal, Kimberly M.
Object Type: Article
System: The UNT Digital Library
Inadequate thermal refuge constrains landscape habitability for a grassland bird species (open access)

Inadequate thermal refuge constrains landscape habitability for a grassland bird species

This article uses the northern bobwhite (Colinus virginianus) as a model species for studying how microclimates serve as refuge against severe weather conditions.
Date: April 11, 2017
Creator: Tomecek, John M.; Pierce, Brian L.; Reyna, Kelly S. & Peterson, Markus J.
Object Type: Article
System: The UNT Digital Library