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The Potential Role of Nanotechnology in Therapeutic Approaches for Triple Negative Breast Cancer
This review is focused on opportunities for developing new approaches for filling the current void in an effective treatment for Triple Negative Breast Cancer, TNBC, patients. Triple Negative Breast Cancer, TNBC, a highly aggressive and metastatic type of breast cancer, is characterized by loss of expression of the estrogen receptor (ER), progesterone receptor (PR), and a lack of overexpression of the human epidermal growth factor receptor 2 (HER2).
Date:
June 18, 2013
Creator:
Johnson, Rebecca; Sabnis, Nirupama; McConathy, Walter J. & Lacko, Andras G.
System:
The UNT Digital Library
Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model
Article investigates whether thymoquinone (TQ), a bioactive constituent of black seed oil, could suppress the proliferation and induce chemosensitization in human myeloma cells and xenograft mouse model. Overall, the results demonstrate that TQ can enhance the anticancer activity of bortezomib in vitro and in vivo and may have a substantial potential in the treatment of MM.
Date:
December 18, 2013
Creator:
Siveen, Kodappully Sivaraman; Mustafa, Nurulhuda; Li, Feng; Kannaiyan, Radhamani; Ahn, Kwang Seok; Kumar, Alan Prem et al.
System:
The UNT Digital Library