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POSMM: an efficient alignment-free metagenomic profiler that complements alignment-based profiling
Article presents POSMM, Python-Optimized Standard Markov Model classifier, which is a new incarnation of the Markov model approach to metagenomic sequence analysis. The authors claim that by combining POSMM with ultrafast classifiers such as Kraken2, their complementary strengths can be leveraged to produce higher overall accuracy in metagenomic sequence classification than by either as a standalone classifier. POSMM is a user-friendly and highly adaptable tool designed for broad use by the metagenome scientific community.
Date:
March 8, 2023
Creator:
Burks, David J.; Pusadkar, Vaidehi & Azad, Rajeev K.
System:
The UNT Digital Library
N-acylethanolamide metabolizing enzymes are upregulated in human neural progenitor-derived neurons exposed to sub-lethal oxidative stress
Article is a study determining whether ReN cells, a superior cell model system for studying neurodevelopment, differentiation, and neuroprotection, express proteins involved in canonical eCB NAE signaling and whether oxidative stress can induce their expression. This study is a first step toward determining how oxidative stress affects CB1, CB2, FAAH, NAAA, and NAPE-PLD expression and their potential defense against oxidative stress.
Date:
August 8, 2022
Creator:
Duncan, Scott R.; Riordan, Sean M.; Hall, Conner W.; Payne, Andrew J.; Chapman, Kent Dean & Koulen, Peter
System:
The UNT Digital Library
Case report: Early-onset osteoporosis in a patient carrying a novel heterozygous variant of the WNT1 gene
Article presents a case study of a 35 year-old Caucasian woman who experienced multiple vertebral fractures two months after her second pregnancy. The results suggest a potential role of heterozygous WNT1 variants in the pathogenesis of early-onset osteoporosis. The authors suggest that teriparatide is one of the most appropriate available therapies for such cases.
Date:
August 8, 2022
Creator:
Campopiano, Maria Cristina; Fogli, Antonella; Michelucci, Angela; Mazoni, Laura; Longo, Antonella; Borsari, Simona et al.
System:
The UNT Digital Library
Exposure to diesel exhaust particles results in altered lung microbial profiles, associated with increased reactive oxygen species/reactive nitrogen species and inflammation, in C57Bl/6 wildtype mice on a high-fat diet
Article investigating if the exposure to diesel exhaust particles (DEP) can alter commensal lung microbiota, thereby promoting alterations in the lung’s immune and inflammatory responses. This article also explores if diet contributes to the alteration of the commensal lung microbiome.
Date:
January 8, 2021
Creator:
Daniel, Sarah; Phillippi, Danielle; Schneider, Leah J.; Nguyen, Kayla N.; Mirpuri, Julie & Lund, Amie K.
System:
The UNT Digital Library
In silico guided structural and functional analysis of genes with potential involvement in resistance to coffee leaf rust: A functional marker based approach
Article presents novel insights into the molecular nature of the SH genes, thereby opening new avenues for coffee rust resistance molecular breeding.
Date:
July 8, 2020
Creator:
Ferreira, Svio Siqueira; Barka, Geleta Dugassa; Caixeta, Eveline Teixeira & Zambolim, Larcio
System:
The UNT Digital Library
Trypsin induces an aversive response in zebrafish by PAR2 activation in keratinocytes
Article using zebrafish as a model and identifies that trypsin induces an aversive response in zebrafish larvae and adult zebrafish. Results show that the trypsin activates PAR2 on keratinocytes signaling the brain, and this pathway of trypsin-induced escape response will provide a unique communication mechanism in zebrafish.
Date:
October 8, 2021
Creator:
Alsrhani, Abdullah; Raman, Revathi & Jagadeeswaran, Pudur
System:
The UNT Digital Library
Exposure to diesel exhaust particulates and desert sand dust generates microvesicle particles and platelet-activating factor agonists
The authors address the editor in their article, stating that the majority of the general population, particularly, servicemen and women deployed across the globe are exposed to various airborne hazards, including diesel exhaust particulate (DEP) and desert sand dust (DSD). Studies, including the author's study, have shown that exposure to ROS-generating pro-oxidative stressors ranging from environmental carcinogens to pollutants, including cigarette smoke, produces a class of potent phospholipid mediators, Platelet-activating factor (PAF) and PAF-like agonists via oxidative cleavage of lipid membrane glycerophosphocholines (GPCs).
Date:
April 8, 2023
Creator:
Thyagarajan, Anita; Rapp, Christine M.; Schneider, Leah; Lund, Amie K.; Travers, Jeffrey B. & Sahu, Ravi P.
System:
The UNT Digital Library
Silicon versus Superbug: Assessing Machine Learning's Role in the Fight against Antimicrobial Resistance
Article describes how, in his 1945 Nobel Prize acceptance speech, Sir Alexander Fleming warned of antimicrobial resistance (AMR) if the necessary precautions were not taken diligently. This paper explores the applications of ML in predicting and understanding AMR, highlighting its potential in revolutionizing healthcare practices.
Date:
November 8, 2023
Creator:
Coxe, Tallon & Azad, Rajeev K.
System:
The UNT Digital Library