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Message from United States Senator John Cornyn for the 2015 Open Access Symposium captions transcript

Message from United States Senator John Cornyn for the 2015 Open Access Symposium

Video message delivered by United States Senator John Cornyn for the 2015 UNT Open Access Symposium, hosted by the UNT Dallas College of Law.
Date: May 6, 2015
Creator: Cornyn, John, 1952-
Object Type: Video
System: The UNT Digital Library
RNA helicase DP103 and TAK1: a new connection in cancer (open access)

RNA helicase DP103 and TAK1: a new connection in cancer

Article on new markers of tumor metastasis. The authors found that expression of DP103 was significantly upregulated in the metastatic basal subtype of breast cancers in 3 independent cohorts. This elevated DP103 expression correlated with metastatic breast cancer gene signatures and was strongly associated with patient survival. This study provides the first evidence that the RNA helicase DEAD-box protein DP103 is an NF-kB target that could form part of a positive feedback loop contributing to DP103- mediated regulation of TAK1 kinase activity on the major NF-kB kinase IKK2, thus implicating DP103 in the maintenance of this oncogenic signaling arm in human cancer.
Date: May 6, 2015
Creator: Shin, Eun Myoung; Osato, Motomi; Kumar, Alan Prem & Tergaonkar, Vinay
Object Type: Article
System: The UNT Digital Library