Recent studies suggest that the primary action of insulin is on the permeability of cell membranes. This idea may account for the effects of the hormone in broken cell preparations as well as in tissue preparations with intact cells if the concept of the cell membrane is broadened to include endoplasmic reticular extensions and the membranes of subcellular organelles. Following on the initial demonstration that insulin was bound to muscle and the elucidation of the structure of insulin, evidence was presented that this binding involves a sulfur-sulfur linkage between hormone and target tissue. In the present work, skeletal muscle cell ghosts were prepared for use in studying the chemical nature of the attachment of insulin to a relatively pure cell membrane preparation.

Technique used in deriving values of the linac ball tuner settings to produce various fields is discussed briefly, and tables showing ball tuner change numbers and values used in making up the ball tuner change numbers are given.

Preliminary results of tests wit the Westinghouse 100A pump indicate that Al2)3 and tungsten carbide coated bearing-journal assemblies prepared by the Linde process are not promising as substitutes for the graphitar-stellite combination. The front Al2O3 assembly failed at start-up with water and both front and rear tungsten carbide assemblies failed after 121 hours with water at 245 C.

This report provides a table that summarizes the data taken from investigations of gamma radiation of the Bulk Shielding Reactor in an iron-water mixture. The results are plotted on a graph also provided in this document.

The following report is meant to record the premises upon which the site plan for the NTR is already established.

The following report contains two parts on the analysis of astatine, neptunium and plutonium. Part A discusses a bent crystal focusing X-ray spectrometer that has been designed and built for the observation of the X-and gamma-rays emitted in association with radioactive decay. The instrument uses proportional counter detection and is described, as well as associated electronic circuits. The plutonium L X-rays from Cm-242 and the neptunium L X-rays from Am-241 have been measures. Values of the energies and abundances are reported. Then in Part B, it discusses some isotopes of astatine hitherto unreported that have been observed in bombardments of bismuth on the University of California 184" cyclotron.