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Rifazone-8{sub 2} (R-8{sub 2}), a new rifamycin derivative, is shown to preferentially inhibit the growth of virus-transformed chick cells in culture. Macromolecular synthesis and glucose uptake of transformed cells are also appreciably decreased in the presence of low concentrations of R-8{sub 2} where the normal cells appear unaffected. While R-8{sub 2} is shown to be a selective inhibitor of RNA-directed DNA polymerase in vitro, its action on the growth of transformed cells may involve some other mechanism.

Gaseous wastes from the chemical separations processing of spent reactor fuel elements and product finishing operations have been discharged to the atmosphere since 1944. Data on plutonium, beta, iodine, and uranium emissions for the twenty-nine years are provided. The known radioactivity in gaseous wastes and estimated radioactivity in gaseous waste where prime data were not available are presented. Emission data are not included on gaseous wastes emitted from 200 Area facilities which are now under the jurisdiction of other Hanford contractors.

The probabilities and potential consequences of dam failure in California, primarily due to large earthquakes, was estimated, taking as examples eleven dams having a relatively large population downstream. Mortalities in the event of dam failure range from 11,000 to 260,000, while damage to property may be as high as $720 million. It was assumed that an intensity IX or X earthquake (on the Modified Mercalli Scale) would be sufficient to completely fail earthen dams. Predictions of dam failure were based on the recurrence times of such earthquakes. For the dams studied, the recurrence intervals for an intensity IX earthquake varied between 20 and 800 years; for an intensity X between 50 and 30,000 years. For the Lake Chabot and San Pablo dams (respectively 20, 30 years recurrent earthquake times for a intensity X) the associated consequences are: 34,000 (Lake Chabot) and 30,000 (San Pablo) people killed; damage $140 million and $77 million. Evaculation was found to ameliorate the consequences slightly in most cases because of the short time available. Calculations are based on demography, and assume 10 foot floodwaters will drown all in their path and destroy all one-unit homes in the flood area. Damage estimates reflect losses incurred by …

This report presents the results of cleaning activities performed to remove residual sodium from the AI Modular Steam Generator. A description of the cleaning loop, cleaning procedure, results, and visual inspection are included.

Processes and procedures were developed for applying the thin film tungsten electrical intraconnections to the MC2730 RTG ''one-dimensional'' thermopile. After polishing, the surface to be metallized was cleaned with a detergent/organic solvent procedure and then etched with hydrofluoric acid to minimize the oxide. Tungsten contacts were sputtered onto the thermopile and the individual contacts photolithographically defined using a negative acting photoresist in conjunction with a potassium ferricyanide etchant. The processes were used to process 89 thermopiles with an 80 percent effective yield.

In studying the dynamic response of fluid filled cylindrical shells to large internal pressure pulses, it would be advantageous to have a rapid method of computing the final deformed shape of the shell. In treating the dynamic response of liquid metal heat transport system to pressures generated by large sodium/water reactions, determinations of the structural response of various components is only a fraction of the information required to describe the entire event. The problem treated in this report is an initial investigation of the value of correlation parameters for removing the effect of pulse shape on predicted plastic deformation. It is an attempt to extend previous studies by inclusion of elastic/plastic response rather than limiting the model to a rigid/plastic description. Since many of the pressure pulses of interest in piping system analysis do not involve pressures that produce large plastic deformation, it is necessary to include the effect of elastic response. A simple bilinear elastic/strain hardening model was thus chosen for this study. The dynamic response of a bilinear thin ring to various spacially uniform pressure pulses is analyzed. Solutions have been obtained for rectangular and for linear and exponentially decaying pulses. Numerical procedures have been employed to obtain …

Numerous tasks are reported that were done in assistance to the Atlantic Richfield Hanford Company in the area of process technology, and in assistance to the Hanford Plant in the areas of environmental evaluations, radiation protection, and radiation standards and engineering.

KRAKEN is an Eulerian hydrodynamics code capable of treating compressible nonviscous flow of several fluids in a two-dimensional (axially symmetric) region. In many respects it is reminiscent of the FLIC/PIC methods, although it is considerably different in detail. Both Lagrangian and advection (transport) phases of the problem are considered. The code has a straight-forward approach to differencing. The presently used version of the code is discussed; it is hoped that a more efficient version will soon be completed. (RWR)

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A data recovery problem often occurs in nuclear tests when photographic film used to record CRT traces is unavoidably exposed fo gamma rays before it can be retrieved for developing. Studies made to improve recovery of the CRT data from such film are described. Best results were obtained with a procedure involving reversal processing, silver intensification, dye-coupling development, and duplication. (auth)

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In developing radiation detection instrumentation at Rocky Flats, a system concept using plug-in modules was planned. Losses of operational time due to maintenance are drastically reduced as a malfunctioning module can be replaced within minutes. Versatility is another advantage of the modular concept and a particular module can be used in many different system designs. A significant cost savings in system development can also be realized. Two of the timers described are housed in two-wide Nuclear Instrumentation Bin (NIM-BIN) modules and a third model in a one-wide NIM-BIN module. The design uses the latest COS/ MOS (complimentary symmetry metal-oxide semiconductor) integrated circuitry, featuring low power, low cost, and high reliability. These modules were developed specifically for radiation detection systems. Model 24370-21 is used in gross alpha detection systems. Model 27213-21 appears in a medical wound- counter system and the third, Model 27213-23, operates in a gamma spectrometer system. These modules can have application in other related systems as well. Operational procedures and servicing are included. (auth)

In developing radiation detection instrumentation at Rocky Flats, a system concept using plug-in modules was planned. Losses of operational time due to maintenance are drastically reduced as a malfunctioning module can be replaced within minutes. Versatility is another advantage of the modular concept and a particular module can be used in many different system designs. A significant cost savings in system development can also be realized. The scalers described are housed in one-wide Nuclear Instrumentation Bin (NIM-BIN) modules. The design incorporates the latest in COS/MOS (complementary symmetry metal-oxide semiconductor) integrated circuitry, featuring low power, low cost, and high reliability. These inodules were developed specifically for radiation detection systems. Model 24370-31 is used in gross alpha detection systems. Model 27213- 30 appears in a medical wound-counter system, but can be used also in a gamma spectrometer system, or in other related systems. Operational procedures and servicing of units are included. (auth)

The experimentally determined neutron and gamma ray spectra of a Cm/sub 2/O/sub 3/ spontaneously fissioning source are presented. The neutron spectrum is given for the energy range 30 keV to 10 MeV, while the gamma ray spectrum spans the energy range 205 keV to 12 MeV. (auth)

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