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Switchable and Memorable Adhesion of Gold-Coated Microspheres with Electrochemical Modulation
Switchable adhesives using stimuli-responsive systems have many applications, including transfer printing, climbing robots, and gripping in pick and place processes. Among these adhesives, electroadhesive surface can spontaneously adjust their adhesion in response to an external electric field. However, electroadhesives usually need high voltage (e.g. kV) and the adhesion disappears upon turning off the signal. These limitations make them complicated and costly. In this research, we demonstrated a gold-coated silica microsphere (GCSM) with highly switchable and memorable adhesion triggered by a relatively small voltage (<30 V). In the experiment, a silica microsphere with a diameter of 15 μm was glued to a tipless atomic force microscope (AFM) cantilever. The nanoscale thick gold coating was sprayed on the surface of the microsphere by a sputter coater. AFM was used to explore the tunable adhesion with an external voltage at different relative humidity (RH). The results revealed that when applying a positive electrical bias at high RH, the adhesive force increased dramatically while it decreased to almost zero after applying a negative potential. Even if the bias was turned off, the adhesive force state could still be kept and erased on demand by simply applying a negative voltage. The adhesive force can be …
Date:
May 2021
Creator:
Wang, Jie (Materials scientist)
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
Dynamic Assessment as an Approach to French Pronunciation Instruction
This thesis is focused on dynamic assessment (DA), an instructional approach based on Vygotskian sociocultural theory, applied to French pronunciation instruction, which can be neglected or inconsistent in the foreign language curriculum. DA aims to combine instruction and assessment into a cooperative, mediated approach in which the mediator works with the learner to identify and develop emergent abilities. These emergent abilities can appear in what is often referred to as the zone of proximal development (ZPD), or the difference between what a learner can do independently and what he/she can do with mediation, which in the present study was the difference between what the participant could pronounce correctly with or without mediation. In carrying out an individual DA session with a learner, the author aimed to find suggestions of potential benefits by applying DA to French pronunciation instruction and gain a more detailed understanding of the learner's performance than is generally possible from a traditional assessment, which is totally devoid of mediation for the sake of validity and reliability. The study includes a discussion of some potential benefits and limitations related to the use of DA for teaching French pronunciation to intermediate L2 learners based on what was observed in …
Date:
May 2021
Creator:
Center, Sarah M
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
Use of a Virtual Reality Gaming System to Improve Balance in Individuals with Chronic Brain Injury
Wii Fit U games utilize a Wii Balance Board™ (WBB) in a manner that can provide precise feedback contingencies similarly to some forms of balance rehabilitation, thereby potentially increasing the dose of quality therapy with or without the presence of a therapist during post-brain injury rehabilitation. Additionally, an engaging video-game could improve treatment adherence, a critical aspect of making positive functional gains, by potentially increasing the rate and quality of reinforcement embedded in therapy. The present study had three aims: (1) develop a rigorous behavioral therapy for improving balance in individuals living with chronic brain injury using a Wii Fit U game and the WBB; (2) evaluate the program's effects on balance measures using a within-subject experimental design; and (3) assess social validity of behavioral gains by evaluating the program's effects on participant's "subjective balance confidence" (i.e., their Activities-Specific Balance Confidence (ABC) scores). A reversal design is proposed for use with primary study participants, wherein the experimental gameplay condition and no intervention condition are alternated for 6 to 10 weeks. A similar design was used in a truncated fashion with pilot participants, and a multiple baseline design was used with follow-up pilot participants. It was expected that participants would exhibit …
Date:
May 2021
Creator:
Cruz, Selena R
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
Water Shortage in the Himalayas of Himachal Pradesh: Causes, Perceptions, and Impacts
Climate change is a growing problem for those living in the Himalayas, threatening water availability and livelihoods. This research seeks to explore the various factors contributing to water shortage and the factors leading to perceptions of water shortage in Himachal Pradesh, India. This thesis explores data collected from 50 interviews conducted in summer 2019 and seeks to understand why participants of these interviews indicated that they do not experience water shortage. The research highlights the importance of further research and needed action in terms of addressing and mitigating the impacts of climate change in the Himalayas of Himachal Pradesh.
Date:
May 2021
Creator:
Davis, Kayla N
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
A Survey of LGBT Educational Policy and Interventions/Practices of Educators in Texas
This research project sought to holistically understand how educators in Texas understand educational policies that impact LGBT students, their practices, and interventions in the classroom. The project looks at two policies: anti-bullying and sexual education policies, and provides evidence that they are intrinsically linked through the discourse surrounding LGBT issues in Texas schools.
Date:
May 2021
Creator:
De Lima Rocha, Gabriela L
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
Viability Study of Nylon-12 Carbon Fiber Filaments for Use in the Construction of a Powered Lower Body Exoskeleton via Fused Deposition Modeling by Means of Computer Simulation
Members of the elderly population is disproportionately prone to experiencing mobility impairment due to their aging bodies and as a result have frail bodies that are at a higher risk of grave injury due to falling. In order to combat this assistive mobility devices such as exoskeletons have been developed to help patients enhance their range of motion. With additive manufacturing techniques, such as fused deposition modeling (FDM), becoming a more mainstream form of design, the inclusion of lightweight polymers such as nylon 12 as primary construction materials for these devices has increased. In this thesis computer aided design (CAD) software was used to design a prototype lower body exoskeleton and simulation software was used to give the device the characteristics of Stratasys' nylon 12 carbon fiber FDM material to verify it if could be used as the primary construction material for this device when extruded from a FDM printer on either the XZ or ZX printing plane. From the simulations it was found that the material printed along the XZ plane could create a device that could withstand the weight of an average elderly male patient (200 lbs.) as well as the 35 lbs. of force applied to the …
Date:
May 2021
Creator:
Joiner, Michael Andrew Lown
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
Attachment to God: Pathways to Resilience and Posttraumatic Growth
Having a secure attachment to God may act as a buffer against stress. Secure attachment to God has been positively associated with adaptive outcomes following stress, such as higher levels of stress-related growth and fewer maladaptive symptoms including depression, prolonged grief, and traumatic distress. However, relatively few studies have empirically tested the relationship between attachment to God and resilience and posttraumatic growth. Thus, the current study explored the potential associations and pathways through which attachment to God is associated with resilience and posttraumatic growth in a sample of 303 suddenly and/or traumatically bereaved individuals. The current study found that (a) God attachment avoidance is a unique negative predictor of resilience and posttraumatic growth even when controlling for adult attachment, (b) self-compassion and meaning-making mediate the association between God attachment anxiety and resilience/posttraumatic growth, (c) secure attachment to God is associated with higher levels of resilience than insecure attachment styles, but not with posttraumatic growth, and (d) an increased number of secondary losses is associated with lower levels of resilience. I conclude by discussing my findings in light of the extant literature on attachment to God, resilience, and posttraumatic growth. By better understanding attachment to God and how it may relate …
Date:
August 2021
Creator:
Ellis, Heidi Marie
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
Chicago Renaissance Women: Black Feminism in the Careers and Songs of Florence Price and Margaret Bonds
In this thesis, I explore the careers and songs of Florence Price and Margaret Bonds—two African American female composers who were part of the Chicago Renaissance. Price and Bonds were members of extensive, often informal, networks of Black women that fostered creativity and forged paths to success for Black female musicians during this era. Building on the work of Black feminist scholar Patricia Hill Collins, I contend that these efforts reflect Black feminist principles of Black women working together to create supportive environments, uplift one another, and foster resistance. I further argue that Black women's agency enabled the careers of Price and Bonds and that elements of Black feminism are not only present in their professional relationships, but also in their songs. Initially, I discuss how the background of the Harlem and Chicago Renaissances and racial uplift ideology shaped these women's artistic environment. I then examine how Bonds and Price incorporated, updated, and expanded versions of these ideals in their music and careers. Drawing on the scholarship of Rae Linda Brown, Angela Davis, and Tammy L. Kernodle, I analyze Price's "Song to the Dark Virgin," "Sympathy," and "Don't You Tell Me No" and Bonds's "Dream Variation," "Note on Commercial Theater," …
Date:
August 2021
Creator:
Durrant, Elizabeth
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
What Does It Mean to Go Super Saiyan: Gender Identity and Fandom in the Toonami Release of Dragon Ball Z (1998-2003)
The intention of this thesis is to analyze the representations of masculinity in the anime series Dragon Ball Z as it aired on Cartoon Network's programming block Toonami, specifically the nature in which they were framed and how oppositional interpretations in the fandom became prevalent as a result. The series emphasizes the evolution of its central characters Goku, Vegeta, and Gohan into performing a sensitive masculinity, but there are a prevalence of images in the series that discredit this. Similarly, the way the series was advertised on Toonami placed emphasis on images of superficial violence and reinforced the masculinity that the series was attempting to move beyond. Understanding the ways fans have interpreted Dragon Ball Z on Toonami helps reveal that there is much more to a media text's influence than its themes and representations of gender.
Date:
August 2021
Creator:
Liverett, Nicholas
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
Mankiyali Phonology: Description and Analysis
This thesis provides a detailed description and analysis of the Mankiyali phonology, a hitherto undocumented and endangered language of northern Pakistan. The language is spoken by about 500 people in a remote mountainous area in the Mansehra district of Khyber Pakhtunkhwa Province, Pakistan. The data contained herein is a result of first-hand fieldwork with native Mankiyali speakers between 2019 and 2021. Data collection methods include recordings of naturally occurring discourse (e.g., stories, poems, conversations) and elicitation sessions with native speaker consultants. Topics covered in the thesis include an account of Mankiyali's phonemic inventory, phonotactics, a description of some phonological processes, minimal word constraints, and word stress placement.
Date:
August 2021
Creator:
Paramore, Jonathan Charles
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
Where Have All the Cowboys Gone? Creating the Post 9/11 Westerner
The intention of this thesis is to analyze the figure of the post 9/11 Westerner as a modern character created from the preexisting archetype of the classic Westerner. 3:10 to Yuma (dir. James Mangold), The Assassination of Jesse James by the Coward Robert Ford (dir. Andrew Dominik), and There Will Be Blood (dir. Paul Thomas Anderson) were released in 2007 and featured post 9/11 Westerners dealing with issues of fatherhood, demonstrating the prevalence of this figure within the modern western genre. Fatherhood becomes the prism through which these characters are depicted, which becomes the main source of their anxiety. The events of 9/11 contributed to a fracture of the western myth established by the classic postwar western that results in the post 9/11 Westerner attempting to reclaim a similar mythic status. The post 9/11 Westerner becomes an inversion of the classic Westerner seen through his insecure masculinity and ultimate failure to live up to his own imagined ideals.
Date:
August 2021
Creator:
Possoit, Dylan
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
Electrical Equivalent Modeling of the Reverse Electrowetting-on-Dielectric (REWOD) Based Transducer along with Highly Efficient Energy Harvesting Circuit Design towards Self-Powered Motion Sensor
Among various energy harvesting technologies reverse electrowetting-on-dielectric energy harvesting (REWOD) has been proved to harvest energy from low frequency motion such as many human motion activities (e.g. walking, running, jogging etc.). Voltage rectification and DC-DC boosting of low magnitude AC voltage from REWOD can be used to reliably self-power the wearable sensors. In this work, a commercial component-based rectifier and DC-DC converter is designed and experimentally verified, for further miniaturization standard 180 nm CMOS process is used to design the rectifier and the DC-DC boost converter.This work also includes the MATLAB based model for REWOD energy harvester for various REWOD models. In REWOD energy harvesting, a mechanical input during the motion causes the electrolyte placed in between two dissimilar electrodes to squeeze back and forth thereby periodically changing the effective interfacial area, hence generating alternating current. The alternating current is given to the rectifier design. There is no realistic model that has been developed yet for this technique. Thereby, a MATLAB based REWOD model is developed for the realistic simulation of the REWOD phenomenon. In the work, a comparison of different REWOD models such as planar surface, rough surface and porous models are performed demonstrating the variations in capacitance, current …
Date:
August 2021
Creator:
Gunti, Avinash
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
Resilience in the Face of Stress: Gender Differences in the Relationship between Resilience and Stress among Lesbian and Gay Older Adults in the American South
The minority stress model provides context to understand the mechanisms by which prejudicial experiences contribute to the disproportionate prevalence of adverse physical and mental health outcomes among LGBT people. The transactional model of stress and coping explains the appraisal processes through which people identify stigma-related stimuli as threatening and how they assess available coping resources to counteract these threats. The Connor-Davidson Resilience Scale (CD-RISC) and the Perceived Stress Scale (PSS) were used in this study to measure resilience and stress in a sample of 99 lesbian and gay older adults. Women reported statistically significantly higher levels of resilience and lower levels of perceived stress compared to older gay men. An analysis of covariance (ANCOVA) revealed statistically significant main effects for gender (Cohen's d = .51; ηp2 = .056; F(1,98) = 5.488, p = .021) while controlling for perceived stress (Cohen's d = 1.62; ηp2 = .375; F(1,98) = 55.840, p < .001). An interaction effect between gender and perceived stress was also statistically significant (Cohen's d = .72; ηp2 = .115; F(1,98) = 12.40, p < .001) indicating that the negative relationship between stress and resilience is stronger for older gay men. Clinical implications and relevance to future research are …
Date:
August 2021
Creator:
Poché, Barton J
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
Ecological Responses to Severe Flooding in Coastal Ecosystems: Determining the Vegetation Response to Hurricane Harvey within a Texas Coast Salt Marsh
Vegetative health was measured both before and after Hurricane Harvey using remotely sensed vegetation indices on the coastal marshland surrounding Galveston Island's West Bay. Data were recorded on a monthly basis following the hurricane from September of 2005 until September of 2019 in order to document the vegetation response to this significant disturbance event. Both initial impact and recovery were found to be dependent on a variety of factors, including elevation zone, spatial proximity to the bay, the season during which recovery took place, as well as the amount of time since the hurricane. Slope was also tested as a potential variable using a LiDAR-derived slope raster, and while unable to significantly explain variations in vegetative health immediately following the hurricane, it was able to explain some degree of variability among spatially close data points. Among environmental factors, elevation zone appeared to be the most key in determining the degree of vegetation impact, suggesting that the different plant assemblages that make up different portions of the marsh react differently to the severe flooding that took place during Harvey.
Date:
August 2021
Creator:
Hudman, Kenneth Russell
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
The Changing Role of On-Air Women Journalists: Journalists on Local Television News and Digital Influencers on Instagram
This thesis looks at how women journalists are now also digital influencers on Instagram. It analyzes the gendered expectations of women journalists that are also included on their professional Instagram accounts.
Date:
August 2021
Creator:
Lara, Sarah
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
Community First: An Ethnographic Approach to Understanding Local Perceptions of Sustainability in the Age of Neoliberalism
This work describes ethnographic research completed in order to understand how local community members in Denton, Texas define, conceptualize, and speak about sustainability. The goal of this research is to encourage a more representative approach to sustainability initiatives within the City of Denton by uniting community ideas with local governance. Data for this study was collected through semi-structured interviews with residents, participant observation at community meetings, and quantitative survey analysis. Through the use of a Foucauldian framework for analysis, in conjunction with David Harvey's "entrepreneurial city," and work done in the field of environmental justice, this study highlights a potential link between neoliberal approaches to city governance and community perceptions of sustainability. This research concludes by calling for more representation of all community members within local sustainability initiatives, and provides several suggestions for how this can be achieved.
Date:
May 2021
Creator:
LeMay, Brittany Michelle
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
Social Media Usage among First Responders to Hurricane Harvey
Social media plays an important role during multiple phases of a disaster. While it is widely known that citizens turn to social media during disasters to gain information and send help requests, there is a significant gap in our knowledge of how, or if, first responders use social media to conduct disaster response operations. To help address this gap this study employed qualitative, semi-structured interviews with a sample of first responders (N = 20) who were deployed to Hurricane Harvey in 2017. The interviews sought to gain a better understanding of how social media was used to conduct response operations and identify both limitations and advantages of social media as perceived by first responders. Through a systematic coding process the analysis identified four themes related to social media usage among first responders to disasters: (1) more than just Twitter; (2) rumor has it; (3) one size does not fit all; and (4) timing is everything. The findings of this research highlight the importance of social media for both organizations and individuals involved in responding to disasters.
Date:
May 2021
Creator:
Spinuzzi, Lacey Cook
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
Restore, Reform, React, Revolt: Leopold II and the Risorgimento in the Grand Duchy of Tuscany, 1814-1859
The Risorgimento or "resurrection" of Italy united a collection of independent Italian kingdoms, duchies, and principalities under the auspices of the Piedmontese House of Savoy. No longer was Italy a mere expression géographique, as Austrian Chancellor Klemens von Metternich snidely remarked in 1847, but a united nation state. Studies of the Risorgimento successfully highlight the role of famous Piedmontese and Italian nationalists in demonstrating the success of the movement. However, the smaller states of the peninsula have largely disappeared from these histories. Among these overlooked states is the Grand Duchy of Tuscany and Tuscany's last grand duke, Leopold II of Habsburg-Lorraine. Both are consistently omitted from broader surveys of the peninsula. In rare situations when Leopold II enters the historical narrative he is dismissed as a reactionary, although he maintained a reputation as an enlightened and relatively liberal ruler for the majority of his rule. Especially in anglophone literature, little to no discussion of his thirty-five-year reign is available. This omission creates an unfortunate lacuna in the historiography of the Risorgimento. It is in studies of these smaller Italian states that the intricacies of statecraft, nationalism, and localism are most visible. To understand the extent of the Risorgimento's success, it …
Date:
May 2021
Creator:
Parkey, Rachel E.
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
Using Machine Learning to Develop a Calibration Model for Low-Cost Air Quality Sensors Deployed during a Dust Event
Low-cost sensors have the potential to create dense air monitoring networks that help enhance our understanding of pollution exposure and variability at the individual and neighborhood-level; however, sensors can be easily influenced by environmental conditions, resulting in performance inconsistencies across monitoring settings. During summer 2020, 20 low-cost particulate sensors were deployed with a reference PM2.5 monitor in Denton, Texas in preparation for calibration. However, from mid to late-summer, dust transported by the Saharan Air Layer moved through the North Texas region periodically, influencing the typical monitoring pattern exhibited between low-cost sensors and reference instruments. Traditional modeling strategies were adapted to develop a new approach to calibrating low-cost particulate sensors. In this study, data collected by sensors was split according to a novel dust filter into dust and non-dust subsets prior to modeling. This approach was compared with building a single model from the data, as is typically done in other studies. Random forest and multiple linear regression algorithms were used to train models for both strategies. The best performing split-model strategy, the multiple linear regression models split according to dust and non-dust subsets (combined R2 = 0.65), outperformed the best performing single-model strategy, a random forest model (R2 = 0.49). …
Date:
May 2021
Creator:
Hickey, Sean
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
The Use of Instructive Feedback to Promote Emergent Verbal Responses: A Replication
Previous research has incorporated instructive feedback (IF) within mastered listener-by-name trials with two children diagnosed with autism spectrum disorder (ASD). Participants in a previous study acquired the secondary targets and also demonstrated emergent responding (i.e., listener-by-feature, tact-by-feature, intraverbal, and reverse intraverbal). The current study replicated a previous study on IF with two children with ASD. Therapists conducted a series of three sessions of mastered listener-by-name trials (e.g., "Show me otter," and the participant selecting the picture of the otter) and provided IF statements for features of the target stimuli (e.g., "It lives in rivers."). We measured participants' echoic responding and required attending to the target stimulus during IF trials, and we evaluated acquisition of secondary targets and emergent responses using a concurrent multiple probe design across sets. We observed increased correct responding for secondary targets and emergent responses for the first set of stimuli with both participants. However, one participant did not engage in emergent responses for the two remaining sets. Results suggest that related verbal operant response relations of secondary targets may result after IF, but the extent of emergence may be idiosyncratic.
Date:
August 2021
Creator:
Laddaga Gavidia, Valeria
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
Exploitation, Justification and Overcoming through Voice: Exploring American Slavery and the Slave Narrative in "The Handmaid's Tale"
To what extent does Margaret Atwood draw from American slavery to write The Handmaid's Tale? How does Offred's narrative compare with traditional slave narratives, and to what effect? This thesis explores intersectionality (or lack thereof) in The Handmaid's Tale and compares Offred's narrative to traditional slave narratives to find answers to why Atwood chose to draw from American slavery to write her novel in the first place. Offred's narrative is compared to three traditional slave narratives written/orated by three women, Harriet Jacobs, Hannah Crafts, and Mary Prince, to demonstrate how enslavement dehumanizes Offred in similar or different ways to these three women, and to reveal how the enslavement of and violence committed against the female slave body ultimately deforms even the most intimate human relationships in both Gilead and in historical American slavery. I discuss other tactics used to maintain control of the slaves both in Gilead and in historical American slavery, with particular emphasis on the development of justifications for enslavement in both societies. Violence against the body is not enough in Gilead, so Gilead implements religious rhetoric and controls knowledge to maintain its control of the Handmaids. Despite being used to control, religion also becomes a source of …
Date:
August 2021
Creator:
Brown, Kaitlyn
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
Wildfire Influence on Rainfall Chemistry and Deposition in Texas during the 2011-2014 Drought
From 2011 to 2014, one of the most severe and intense droughts in Texas recorded history led to widespread wildfires across the state, with unknown effects on atmospheric nutrient and pollutant deposition. The objectives of this research were to: (1) characterize the frequency, magnitude, and spatiotemporal distribution of Texas wildfires (2011-2014); (2) identify smoke occurrence and source regions at eight Texas National Atmospheric Deposition Program (NADP) National Trends Network (NTN) sites (2011); and (3) quantify the influence of wildfire on weekly rainwater chemistry and deposition in 2011 at three NADP sites (Sonora, LBJ Grasslands, Attwater Prairie NWR). Data on large wildfires, smoke occurrence, and rainfall chemistry and deposition were coupled with principal component and back-trajectory analysis to address these objectives. Between 2011-2014, 72% of all wildfires occurred in 2011, accounting for 90% of the total area burned. In total, there were 17 extreme wildfires (i.e., in the 95th percentile of hectares burned), of which 11 occurred in 2011. Wildfire activity was concentrated in West Texas ecoregions and consumed primarily shrub/scrub and grassland/herbaceous land cover. Although West Texas experienced the most wildfires, smoke at the NADP locations in 2011, the "high-fire year," was more frequent in East Texas due to regional …
Date:
August 2021
Creator:
Williamson, Thomas
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
Asynchronous Level Crossing ADC for Biomedical Recording Applications
This thesis focuses on the recording challenges faced in biomedical systems. More specifically, the challenges in neural signal recording are explored. Instead of the typical synchronous ADC system, a level crossing ADC is detailed as it has gained recent interest for low-power biomedical systems. These systems take advantage of the time-sparse nature of the signals found in this application. A 10-bit design is presented to help capture the lower amplitude action potentials (APs) in neural signals. The design also achieves a full-scale bandwidth of 1.2 kHz, an ENOB of 9.81, a power consumption of 13.5 microwatts, operating at a supply voltage of 1.8 V. This design was simulated in Cadence using 180 nm CMOS technology.
Date:
August 2021
Creator:
Pae, Kieren
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
Studies on the Fibrinolytic Pathway in Zebrafish
Fibrinolysis pathway is an important mechanism for dissolution of fibrin clot by the action of plasmin which is formed from plasminogen, a zymogen via the action of plasminogen activators, i.e. tissue plasminogen activator and urinary plasminogen activator. The regulation of fibrinolysis system in vivo is maintained by plasminogen activators and natural inhibitors i.e. α2-antiplasmin, α2-macroglobulin, Thrombin-activatable fibrinolysis inhibitor (TAFI) and plasminogen activator inhibitor 1 and 2 (PAI-1and PAI-2). There are several fibrinolytic assays developed for human plasma but there are no reports describing fibrinolytic assay using zebrafish plasma. In this study, a fibrinolytic assay via using small amount of zebrafish plasma was developed. This assay was performed under different conditions; one by the addition of exogenous tissue plasminogen activator alone to the pooled zebrafish plasma along with calcium chloride and thromboplastin, second Dade ACTIN was used instead of tissue plasminogen activator and third Dade ACTIN along with thromboplastin was used. Epsilon amino caproic acid (EACA), a synthetic antifibrinolytic agent was used at different concentrations to inhibit fibrinolysis successfully. Similar experiments were performed on human plasma as well to check the applicability of the assay to humans and positive results were obtained. Furthermore, knockdown of tissue plasminogen activator and plasminogen genes …
Date:
August 2021
Creator:
Gill, Jaspreet Kaur
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library