In Vitro Electrochemical Evaluation of Bioelectronic Arrays (open access)

In Vitro Electrochemical Evaluation of Bioelectronic Arrays

In this paper, I sought to identify and develop a protocol on electrode arrays as a result of rapid aging by applying rapid current over time. We, however, apply a different approach by using phosphate buffer solution (PBS) to mimic the conditions of the body. Here we have established an in vitro protocol for accelerated aging, a process that involves testing in extreme conditions such as oxygen, heat, sunlight, humidity, and vibration aimed at speeding the normal aging process of items; on commercially available shape memory polymer electrode arrays from Qualia over a period of 30 days in PBS. Two electrode arrays were placed in 37°C and 2 were placed in 57°C. Open lead electrochemical impedance spectroscopy (EIS) was conducted on the electrode arrays. Overall, the results showed there were differences in average impedance during this accelerated aging protocol. At 37°C we see that the average impedance values increased as the electrodes were aged at 1kHz from an average of 4.15E6 to 9.14E6 Ohms. At 57°C electrode arrays 4 and 5 showed strong P values well above 0.05, but average impedance increased drastically from 3.27E6 to 9.97E6 and P value of 0.04 from measurement day 24 to day 30. This …
Date: December 2021
Creator: Singh, Sukhpreet
System: The UNT Digital Library