Article describes study which used an 18S rRNA gene fragment metabarcoding approach to assess the eukaryotic assemblage of 62 individuals representing 16 nonhuman primate NHP species to better understand the factors that influence the assembly and diversity of gut-associated eukaryotes.

This article gives an overview of the discovery of small-molecule bioprecursor prodrugs carrying the para-quinol scaffold on the steroidal A-ring that are preferentially metabolized in the CNS to the corresponding estrogens. Selected examples are shown to illustrate that, independently of the route of administrations and duration of treatments, these agents produce high concentration of estrogens only in the CNS without peripheral hormonal liability. 10β,17β-Dihydroxyestra-1,4-dien-3-one (DHED) has been the best-studied representative of this novel type of prodrugs for brain and retina health. Specific applications in preclinical animal models of centrally-regulated and estrogen-responsive human diseases, including neurodegeneration, menopausal symptoms, cognitive decline and depression, are discussed to demonstrate the translational potential of their prodrug approach for CNS-selective and gender-independent estrogen therapy with inherent therapeutic safety.

Paper describes the results of a study examining magnesium intake in Hispanic adults, using data from the NHANES from 1999-2014, stratified by gender, Hispanic origins, age, and poverty income ratio (PIR) level.

Study examines the interaction between a key pathogenic HIV-1 viral protein, Nef, and ubiquitin (Ub)-protein ligase E3A (UBE3A).