Very few studies have investigated how psychopathic traits might contribute to our understanding of prejudicial attitudes. Moreover, previous studies involve a number of limitations which cloud interpretation of their findings. The current study examined the relationship between prejudice and a number of its predictors (e.g., social dominance orientation (SDO) and right-wing authoritarianism (RWA)), while also including psychopathic traits and an innovative new measure of empathy using an online sample. A path analytic framework was employed to comprehensively model relations among psychopathic traits, SDO, RWA, and affective empathy domains in the prediction of generalized prejudice. Overall, there was support for certain psychopathic traits being modest predictors of racial prejudice, although more proximal measures were much stronger predictors. The results revealed a number of novel relationships that may help in further understanding the links between psychopathic propensities, empathy, and social-cognitive variables predictive of racial prejudice.