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Humanin Attenuates NMDA-Induced Excitotoxicity by Inhibiting ROS-dependent JNK/p38 MAPK Pathway
This article highlights a study aimed to investigate neuroprotective mechanisms of HN. We analyzed intracellular Ca²+ levels, reactive oxygen species (ROS) production, and the MAPKs signal transduction cascade using an in vitro NMDA-mediated excitotoxicity of cortical neurons model.
Date:
September 29, 2018
Creator:
Yang, Xiaorong; Zhang, Hongmei; Wu, Jinzi; Yin, Litian; Yan, Liang-Jun & Zhang, Ce
System:
The UNT Digital Library
Cataract Preventive Role of Isolated Phytoconstituents: Findings from a Decade of Research
This review aims to find effective phytoconstituents in cataract treatments in vitro, ex vivo, and in vivo. Scientists have focused their attention not only for anti-cataract activity in vitro, but also in ex vivo and in vivo from the review of active phytoconstituents in medicinal plants. In our present review, we identified 58 active phytoconstituents with strong anti-cataract effects at in vitro and ex vivo with lack of in vivo studies.
Date:
October 26, 2018
Creator:
Lim, Vuanghao; Schneider, Edward; Wu, Hongli & Pang, Iok-Hou
System:
The UNT Digital Library