This dissertation presents an empirical investigation of learning from online courses. The current dissertation examined student participation, using Arbaugh et al.'s Community of Inquiry (CoI) survey instrument and Biggs et al.'s revised version of the Study Process Questionnaire (R-SPQ-2F) to determine CoI influences on learning from the students' perspective. This study is in response to Rourke and Kanuka's call to provide further empirical evidence about CoI conceptual framework connections to deep and meaningful learning. The purpose of this study was to examine the impact of the elements of CoI, cognitive, social, and teaching presences and students' learning approaches to students' perceived learning. Students enrolled in traditional, online, and, blended courses during the 2016 spring semester at a southwestern university participated in a web-based survey. Structural equation modeling was used to test the indirect effects between the elements of CoI, learning approaches, and perceived learning. Student's deep approach to learning was found to have an indirect effect between cognitive presence and perceived learning. However, this study's findings, when the CoI framework was viewed in its entirety, failed to provide evidence to simulate deep and meaningful learning.