The purpose of this study was to examine the effect of post-resistance exercise alcohol ingestion on LPS-stimulated production of IFNγ, TNF-α, IL-1β, IL-6, IL-8, and IL-10. Recreationally resistance-trained men (n = 10, 25 ± 3 yr, 177 ± 7 cm, 83.8 ± 15.7 kg, 14.8 ± 8.5% body fat) and women (n = 8, 23 ± 2 yr, 161 ± 3 cm, 59.5 ± 6.0 kg, 26.5 ± 3.0% body fat) completed the study. Participants visited the laboratory for an initial visit at which time they were screened, familiarized with procedures, and had their 1-repetition maximum (1RM) back squat tested. Subsequently, participants visited the laboratory 2 more times and completed 2 identical heavy resistance exercise bouts (6 sets of 10 repetitions of 80% 1RM back squat) after which a beverage, either containing alcohol (alcohol condition, ALC; 1.09 g EtOH per kg fat free mass) or water (placebo condition, PLA), was administered. Blood samples were collected before exercise (PRE), and at 3 hours (3h) and 5 hours (5h) after exercise. Samples were stimulated with lipopolysaccharide (LPS) and cultured overnight. Supernatant was collected and analyzed for IFNγ, TNF-α, IL-1β, IL-6, IL-8, and IL-10. A significant (p < 0.05) main effect for time …