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SPHK1 regulates proliferation and survival responses in triple-negative breast cancer (open access)

SPHK1 regulates proliferation and survival responses in triple-negative breast cancer

Article describes study suggesting that the inhibation of sphingosine kinase 1 (SPHK1) can attenuate ERK1/2 and AKT signaling and reduce growth of triple-negative breast cancer (TNBC) cells in vitro and in a xenograft SCID mouse model.
Date: March 27, 2014
Creator: Datta, Arpita; Loo, Ser Yue; Huang, Baohua; Wong, Lingkai; Tan, Sheryl S.L.; Tan, Tuan Zea et al.
System: The UNT Digital Library