This study investigated the relation between maternal self-efficacy, depression, and intimate partner violence among Mexican immigrant and Mexican mothers. The research was conducted using a parallel mixed methods approach including both qualitative and quantitative methods. A total of 136 mothers living in the United States and Mexico completed surveys, and 10 mothers participated in semi-structured interviews. In a regression on maternal depression, living in Mexico as opposed to the U.S., psychological violence, and maternal self-efficacy were significant predictors of maternal depression. In the qualitative data analysis, we found five main themes: perceptions, cultural influence, involvement, resources, and barriers. In this stage of the study, Mexican and Mexican immigrant mothers described in detail their experiences of being a mother, their perceptions of maternal self-efficacy, and the influence of intimate partner violence and depression on their effectiveness as mothers. Overall, Mexican immigrant families appeared to have healthier relationships and greater well-being than Mexican families.