The proposed work aims to address three major challenges to the field of regenerative medicine: 1) the growth and expansion of regenerative cells outside the body in controlled in vitro environments, 2) supportive vascular supply for large tissue engineered constructs, and 3) interactive biomaterials that can orchestrate tissue development in vivo. Toward this goal, we have engaged a team of scientists with expertise in cell and molecular biology, physiology, biomaterials, controlled release, nanomaterials, tissue engineering, bioengineering, and clinical medicine to address all three challenges. This combination of resources, combined with the vast infrastructure of the WFIRM, have brought to bear on projects to discover and test new sources of autologous cells that can be used therapeutically, novel methods to improve vascular support for engineered tissues in vivo, and to develop intelligent biomaterials and bioreactor systems that interact favorably with stem and progenitor cells to drive tissue maturation. The Institute’s ongoing programs are aimed at developing regenerative medicine technologies that employ a patient’s own cells to help restore or replace tissue and organ function. This DOE program has provided a means to solve some of the vexing problems that are germane to many tissue engineering applications, regardless of tissue type or …

Daily newspaper from Chickasha, Oklahoma that includes local, state, and national news along with advertising.

Weekly newspaper from Canadian, Texas that includes local, state and national news along with some advertising.

Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.

Weekly newspaper from Mount Vernon, Texas that includes local, state and national news along with advertising.

Semi-weekly newspaper from Mabank, Texas that includes local Cedar Creek Lake area, state and national news along with extensive advertising.

Weekly newspaper from Naples, Texas that includes local, state and national news along with advertising.

Weekly newspaper from Brownwood, Texas that includes local, state and national news along with advertising.

Interview with Giancarlo Quijano, West German-born Colombian immigrant to Denton, Texas, for the DFW Metroplex Immigration Oral History Project. The interview includes Quijano's personal experiences from his childhood in West Germany, life in Colombia during the 1990s violence, his family's immigration to Texas, his expectations of the U.S., and the subsequent culture shock. Quijano talks about the transition to American life, attending college as an international student, his experiences with the citizenship process, and his thoughts on the immigration debate.

Student newspaper of the University of Oklahoma in Norman, Oklahoma that includes national, local, and campus news along with advertising.

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Weekly newspaper from Valley Mills, Texas that includes local, state, and national news along with advertising.

Weekly newspaper from Crowley, Texas that includes local, state, and national news along with advertising.

Weekly newspaper from Garber, Oklahoma that includes local, state, and national news along with advertising.

Weekly newspaper from Tulia, Texas that includes local, state, and national news along with extensive advertising.

Weekly student newspaper from Howard Payne University in Brownwood, Texas that includes local, state and campus news along with advertising.

The overall hypothesis of this grant application is that low dose ionizing radiation (LDIR) elicits adaptive responses in part by causing heritable DNA methylation changes in the epigenome. This novel postulate was tested by determining if the level of DNA methylation at the Agouti viable yellow (A{sup vy}) metastable locus is altered, in a dose-dependent manner, by low dose radiation exposure (<10 cGy) during early gestation. This information is particularly important to ascertain given the increased use of CT scans in disease diagnosis, increased number of people predicted to live and work in space, and the present concern about radiological terrorism. We showed for the first time that LDIR significantly increased DNA methylation at the A{sup vy} locus in a sex-specific manner (p=0.004). Average DNA methylation was significantly increased in male offspring exposed to doses between 0.7 cGy and 7.6 cGy with maximum effects at 1.4 cGy and 3.0 cGy (p<0.01). Offspring coat color was concomitantly shifted towards pseudoagouti (p<0.01). Maternal dietary antioxidant supplementation mitigated both the DNA methylation changes and coat color shift in the irradiated offspring (p<0.05). Thus, LDIR exposure during gestation elicits epigenetic alterations that lead to positive adaptive phenotypic changes that are negated with antioxidants, indicating …

Weekly newspaper from Port Aransas, Texas on Mustang Island that includes local, state and national news along with extensive advertising.

This video recording presents Outrageous Oral Volume 3. For this event, attendees welcomed members of The Dallas Way GLBT History Project to the University of North Texas (UNT) campus. This is a group of community members dedicated to preserving the history of gay life in Dallas, and their Outrageous Oral events bring together artists, activists, and civic leaders to share their stories of life as gay people in the DFW area, pre-Stonewall, pre-DADT, and during the first cataclysmic years of the AIDS Epidemic. These oral histories are alternately hilarious and compelling, heartwarming and devastating. The Digital Scholarship Cooperative (DiSCo) and the UNT Libraries join the students of Glad: UNTs Queer Alliance, and the UNT Multicultural Center in bringing these stories to campus on National Coming Day (October 11, 2012), to help build bridges between UNT and the community, and between generations of gay and trans men and women. The UNT Libraries will be represented tonight by Arturo Ortega, who will share stories of what it was like growing up in Laredo, Texas.

Weekly newspaper from De Leon, Texas that includes local, state and national news along with advertising.

Recital presented at the UNT College of Music Recital Hall in partial fulfillment of the Doctor of Musical Arts (DMA) degree.

Weekly newspaper from Olney, Texas that includes local, state, and national news along with advertising.

This report addresses the Bazaar diplomacy examining Iran's nuclear bargaining tactics.

Weekly newspaper from Albany, Texas that includes local, state and national news along with advertising.