Buruli ulcer (BU), an infectious disease caused by Mycobacterium ulcerans, is the third most common mycobacterial disease after leprosy and tuberculosis and a WHO-defined neglected tropical disease. Despite years of research, the mode of transmission of BU remains unknown. This master’s thesis provides an integrated spatial analysis of disease dynamics in Ghana, West Africa, an area of comparatively high BU incidence. Within a case/matched control study design, environmental factors associated with BU infection and spatial behaviors are investigated to uncover possible links between individual daily activity spaces and terrains of risk across disturbed landscapes. This research relies upon archival and field-collected data and analyses conducted with geographical information systems (GIS).

More Texans are living with HIV infection than ever before. in fact, there has been a 6% increase annually, since 2002. This trend is not a result of increased HIV/AIDS incidence, but rather improving life expectancy of those living with HIV. Due to significant advances in HIV/AIDS testing, prevention, and treatment, individuals with HIV are living longer than ever before. However, throughout the state, the life expectancy of a person infected with HIV/AIDS varies spatially. This study investigates and attempts to explain the spatial distribution of HIV/AIDS survival rates by examining neighborhood socioeconomic characteristics. the results suggest that, contrary to expectation, the lowest survival rates occur, not in extreme poverty areas, but rather in moderate SES areas. Too rich to qualify for free treatments, but not rich enough to afford purchasing such treatments, the middle income living with HIV infection are caught between the cracks. the results provide important input for targeting public health interventions to improve HIV/AIDS survival.

Maternal mortality is the leading cause of death among women in Nigeria, especially women aged between 15 and 19 years. This research examines the geography of maternal mortality in Nigeria and the role of cultural and religious practices, socio-economic inequalities, urbanization, access to pre and postnatal care in explaining the spatial pattern. State-level data on maternal mortality rates and predictor variables are presented. Access to healthcare, place of residence and religion explains over 74 percent of the spatial pattern of maternal mortality in Nigeria, especially in the predominantly Muslim region of northern Nigeria where poverty, early marriage and childbirth are at its highest, making them a more vulnerable population. Targeting vulnerable populations in policy-making procedures may be an important strategy for reducing maternal mortality, which would also be more successful if other socio-economic issues such as poverty, religious and health care issues are promptly addressed as well.