Advances in sequence genomics have resulted in an accumulation of a huge number of protein sequences derived from genome sequences. However, the functions of a large portion of them cannot be inferred based on the current methods of sequence homology detection to proteins of known functions. Three-dimensional structure can have an important impact in providing inference of molecular function (physical and chemical function) of a protein of unknown function. Structural genomics centers worldwide have been determining many 3-D structures of the proteins of unknown functions, and possible molecular functions of them have been inferred based on their structures. Combined with bioinformatics and enzymatic assay tools, the successful acceleration of the process of protein structure determination through high throughput pipelines enables the rapid functional annotation of a large fraction of hypothetical proteins. We present a brief summary of the process we used at the Berkeley Structural Genomics Center to infer molecular functions of proteins of unknown function.

Minutes for the September 2, 2007 meeting of the Texas Stonewall Democratic Caucus Executive Board Conference Call, discussing proxy voting, bylaws, and other topics addressed during the meeting. Included are handwritten notes from the board conference call on September 2, 2007.

Minutes for the September 2, 2007 meeting of the Texas Stonewall Democratic Caucus Executive Board Conference Call, discussing proxy voting, bylaws, and other business addressed during the meeting.

Minutes for the September 2, 2007 meeting of the Texas Stonewall Democratic Caucus Executive Board Conference Call, discussing proxy voting, bylaws, and other topics addressed during the meeting.

Semi-weekly newspaper from Livingston, Texas that includes local, state and national news along with advertising.

Daily newspaper from Baytown, Texas that includes local, state, and national news along with advertising.

A multi-column breakdown of the various topics discussed by the Texas Stonewall Democratic Caucus, as well as a brief description of each topic.

Daily newspaper from Altus, Oklahoma that includes local, state, and national news along with advertising.

Daily newspaper from Sapulpa, Oklahoma that includes local, state, and national news along with advertising.

Semiweekly newspaper from Carthage, Texas that includes local, state, and national news along with advertising.

Daily newspaper from Chickasha, Oklahoma that includes local, state, and national news along with advertising.