Splenomegaly is frequently found in non-Hodgkin's lymphoma (NHL) patients. This study evaluated the implications of splenic volume change in response to radioimmunotherapy (RIT). Twenty-nine NHL patients treated with radiolabeled-Lym-1 and 9 breast cancer patients (reference group) treated with radiolabeled-ChL6, BrE-3 or m170 were analyzed using CT splenic images obtained before and after RIT. Patient-specific radiation doses to spleen were determined using actual splenic volume determined by CT and body weight. In 13 of 29 NHL patients who had splenic volume {le} 310 ml, there was no or small change (-23 to 15 mL) in splenic volume, despite splenic doses as high as 14.4 Gy. Similarly, in a reference group of 9 breast cancer patients, there was no or small change (-5 to 13 mL), despite splenic doses as high as 11.4 Gy. In contrast, 13 of 29 NHL patients who had splenic volume 380-1400 mL, splenic volume decreased by 68 to 548 mL despite splenic doses as low as 1.40 Gy. Ten of 29 NHL patients with greater than a 15% decrease in splenic volume after RIT had nodal tumor regression (5 CR, 5 PR). In the remaining 19 NHL patients with less than a 15% decrease in splenic volume …

Reliable estimates of the seismic source spectrum are necessary for accurate magnitude, yield, and energy estimation. In particular, how seismic radiated energy scales with increasing earthquake size has been the focus of recent debate within the community and has direct implications on earthquake source physics studies as well as hazard mitigation. The 1-D coda methodology of Mayeda et al. has provided the lowest variance estimate of the source spectrum when compared against traditional approaches that use direct S-waves, thus making it ideal for networks that have sparse station distribution. The 1-D coda methodology has been mostly confined to regions of approximately uniform complexity. For larger, more geophysically complicated regions, 2-D path corrections may be required. The complicated tectonics of the northern California region coupled with high quality broadband seismic data provides for an ideal ''apples-to-apples'' test of 1-D and 2-D path assumptions on direct waves and their coda. Using the same station and event distribution, we compared 1-D and 2-D path corrections and observed the following results: (1) 1-D coda results reduced the amplitude variance relative to direct S-waves by roughly a factor of 8 (800%); (2) Applying a 2-D correction to the coda resulted in up to 40% variance …

Dislocation substructures developed in high-purity Mo single crystals deformed under uniaxial compression at room temperature to a total strain of {approx} 0.5% with a strain rate of 1 s{sup -1} have been investigated using transmission electron microscopy (TEM) techniques in order to elucidate the underlying micromechanisms of the anomalous operation of {l_brace}0{bar 1}1{r_brace} slip systems, i.e. Schmid-law violation, in bcc metals. The crystals were oriented with the stress axis parallel to a nominal single-slip orientation of [{bar 2}920], in which the ({bar 1}01)[111] slip system is the only system having a maximum value of Schmid factor (m = 0.5). Nevertheless, the recorded stress-strain curve reveals no single-slip or easy-glide stage, and the anomalous slip occurs in both (011) and (0{bar 1}1) planes. TEM examination of the dislocation structure in the ({bar 1}01) primary slip plane reveals that in addition to the operation of the ({bar 1}01)[111] slip system, the coplanar ({bar 1}01)[1{bar 1}1] slip system that has a much smaller Schmid factor (m = 0.167) is also operative. Similarly, the (0{bar 1}1)[111] slip system (m = 0.25) is cooperative with the coplanar (0{bar 1}1)[{bar 1}11] system (m = 0.287), and the (011)[1{bar 1}1] slip system (m = 0.222) is cooperative …

The Sustained Spheromak Physics Experiment (SSPX) uses a magnetized coaxial gun to form and sustain spheromaks by helicity injection. Internal probes give the magnetic profile within the gun. Analysis of these data show that a number of commonly applied assumptions are not completely correct, and some previously unrecognized processes may be at work. Specifically, the fraction of the available vacuum flux spanning the gun that is stretched out of the gun is variable and not usually 100%. The n=1 mode that is present during sustained discharges has its largest value of {delta}B/B within the gun, so that instantaneously B within the gun is not axisymmetric. By applying a rigid-rotor model to account for the mode, the instantaneous field and current structure within the gun are determined. The current density is also highly non-axisymmetric and the local value of {lambda} {triple_bond} {mu}{sub 0}j{sub {parallel}}/B is not constant, although the global value {lambda}{sub g} {triple_bond} {mu}{sub 0}I{sub g}/{psi}{sub g} closely matches that expected by axisymmetric models. The current distribution near the gun muzzle suggests cross-field current exists, and this is explained as a line-tying reaction to plasma rotation.

This Report is on Molecular Energy Transfer of Gordon Conference

Corrosion in the vapor space and at the liquid/air interface of the Department of Energy (DOE) high level waste (HLW) tanks have emerged as potentially active corrosion mechanisms. Controls on the solution chemistry are in place to preclude the initiation and propagation of further nitrate induced pitting and stress corrosion cracking. However, recent experience has shown that steel not in contact with the bulk waste solution but exposed to the vapor space above the bulk waste and the liquid/air interface may be vulnerable to pitting or stress corrosion cracking. Experimentation was performed to determine the cyclic polarization behavior of ASTM A537 low carbon steel, the materials of construction of the tanks, in the vapor space above simulated waste solution. The results suggest steel in the vapor space is protected provided the bulk solution issufficiently inhibited.

Solid state experiments at extreme pressures, 10-100 GPa (0.1-1 Mbar) and strain rates (10{sup 6}-10{sup 8} s{sup -1}) are being developed on high-energy laser facilities. The goal is an experimental capability to test constitutive models for high-pressure, solid-state strength for a variety of materials. Relevant constitutive models are discussed, and our progress in developing a quasi-isentropic, ramped-pressure, shockless drive is given. Designs to test the constitutive models with experiments measuring perturbation growth due to the Rayleigh-Taylor instability in solid-state samples are presented.

Three-dimensional diffraction microscopy offers the potential for high-resolution aberration-free diffraction-limited 3D images without the resolution and depth-of-field limitations of lens-based tomographic systems. Critical issues in obtaining a high-quality image include: (1) Data collection--signal to noise, system stability, dynamic range, automation; (2) Alignment of diffraction patterns with respect to one another; (3) Assembly of the diffraction data into a diffraction volume; and (4) Efficient algorithms for applying phase retrieval techniques to the diffraction volume; (5) Stability of the three-dimensional phase retrieval process; (6) Techniques for determining the object support; and (7) Treatment of missing data, both within the beamstop region and elsewhere. They have obtained high-quality 3D reconstructions from X-ray diffraction data alone. This is an important step, as it does not require a low-resolution image to fill in the beamstop region.

An indirect method for determining cross sections for reactions proceeding through a compound nucleus is presented. Exploring indirect approaches for obtaining reaction cross sections is important since a large number of reactions relevant to astrophysics cannot be measured with currently available techniques. Of particular importance are reactions involving unstable nuclei. Some applications of the Surrogate nuclear reactions method are considered and challenges that need to be addressed are outlined.

Helix structures have been proposed [1] for accelerating low energy ion beams using MV/m fields in order to increase the coupling efficiency of the pulsed power system and to tailor the electromagnetic wave propagation speed with the particle beam speed as the beam gains energy. Calculations presented here show the electromagnetic field as it propagates along the helix structure, field stresses around the helix structure (for voltage breakdown determination), optimizations to the helix and driving pulsed power waveform, and simulations showing test particles interacting with the simulated time varying fields.

A strategy to study flavor-dependent parton energy loss by tagging heavy quark jets in p+p, p+Pb and Pb+Pb collisions at the LHC is discussed. Estimates for production cross-sections and experimental techniques employed at collider detectors to search for Q{bar Q} jets are presented and a brief evaluation of the capabilities of CMS, ALICE and ATLAS detectors are given.

Resonance-transition alkali-vapor lasers have only recently been demonstrated [1] but are already attracting considerable attention. Alkali-atom-vapor gain media are among the simplest possible systems known, so there is much laboratory data upon which to base performance predictions. Therefore, accurate modeling is possible, as shown by the zero- free-parameter fits [2] to experimental data on alkali-vapor lasers pumped with Ti:sapphire lasers. The practical advantages of two of the alkali systems--Rb and Cs--are enormous, since they are amenable to diode-pumping [3,4]. Even without circulating the gas mixture, these lasers can have adequate cooling built-in owing to the presence of He in their vapor cells. The high predicted (up to 70%) optical-to-optical efficiency of the alkali laser, the superb (potentially 70% or better) wall-plug efficiency of the diode pumps, and the ability to exhaust heat at high temperature (100 C) combine to give a power-scalable architecture that is lightweight. A recent design exercise [5] at LLNL estimated that the system ''weight-to-power ratio'' figure of merit could be on the order of 7 kg/kW, an unprecedented value for a laser of the 100 kW class. Beam quality is expected to be excellent, owing to the small dn/dT value of the gain medium. There is …

Article discussing thermochemical and theoretical studies of dimethylpyridine-2,6-dicarboxylate and pyridine-2,3-, pyridine-2,5- and pyridine-2,6-dicarboxylic acids.

Article discussing the synthesis of the five-coordinate ruthenium (II) complexes and reactions with phenyldiazomethane and phenylacetylene.

Recently observed hadrons that do not fit into the ''normal'' spectroscopic order should have been produced in old experiments. Are these claims supported by the legacy data? Fermilab Experiment 690 collected a 5 x 10{sup 9} event sample of p+p{yields} p{sub f}+X events at a beam momentum of 800 GeV/c ({radical}s = 38.8 GeV) at Lab G in the Neutrino-East beam line in the Tevatron 1991 fixed target run. The detector was an open geometry magnetic spectrometer with large geometric acceptance and extremely good momentum resolution.

Quantum Monte Carlo (QMC) is an extremely powerful method to treat many-body systems. Usually quantum Monte Carlo has been applied in cases where the interaction potential has a simple analytic form, like the 1/r Coulomb potential. However, in a complicated environment as in a semiconductor heterostructure, the evaluation of the interaction itself becomes a non-trivial problem. Obtaining the potential from any grid-based finite-difference method, for every walker and every step is unfeasible. We demonstrate an alternative approach of solving the Poisson equation by a classical Monte Carlo within the overall quantum Monte Carlo scheme. We have developed a modified ''Walk On Spheres'' algorithm using Green's function techniques, which can efficiently account for the interaction energy of walker configurations, typical of quantum Monte Carlo algorithms. This stochastically obtained potential can be easily incorporated within popular quantum Monte Carlo techniques like variational Monte Carlo (VMC) or diffusion Monte Carlo (DMC). We demonstrate the validity of this method by studying a simple problem, the polarization of a helium atom in the electric field of an infinite capacitor.

A new code and methodology are introduced for solving the fully general relativistic magnetohydrodynamic (GRMHD) equations using time-explicit, finite-volume discretization. The code has options for solving the GRMHD equations using traditional artificial-viscosity (AV) or non-oscillatory central difference (NOCD) methods, or a new extended AV (eAV) scheme using artificial-viscosity together with a dual energy-flux-conserving formulation. The dual energy approach allows for accurate modeling of highly relativistic flows at boost factors well beyond what has been achieved to date by standard artificial viscosity methods. it provides the benefit of Godunov methods in capturing high Lorentz boosted flows but without complicated Riemann solvers, and the advantages of traditional artificial viscosity methods in their speed and flexibility. Additionally, the GRMHD equations are solved on an unstructured grid that supports local adaptive mesh refinement using a fully threated oct-tree (in three dimensions) network to traverse the grid hierarchy across levels and immediate neighbors. A number of tests are presented to demonstrate robustness of the numerical algorithms and adaptive mesh framework over a wide spectrum of problems, boosts, and astrophysical applications, including relativistic shock tubes, shock collisions, magnetosonic shocks, Alfven wave propagation, blast waves, magnetized Bondi flow, and the magneto-rotational instability in Kerr black hole spacetimes.

The biological generation of oxygen by the oxygen-evolving complex in photosystem II (PS II) is one of natures most important reactions. The recent X-ray crystal structures, while limited by resolutions of 3.2 to 3.5 A, have located the electron density associated with the Mn4Ca complex within the multi-protein PS II complex. Detailed structures critically depend on input from spectroscopic techniques such as EXAFS and EPR/ENDOR, as the XRD resolution does not allow for accurate determination of the position of Mn/Ca or the bridging and terminal ligand atoms. The number and distances of Mn-Mn/Ca/ligand interactions determined from EXAFS provide important constraints for the structure of the Mn cluster. Here we present data from a high-resolution EXAFS method using a novel multi-crystal monochromator that show three short Mn-Mn distances between 2.7 and 2.8 A and hence the presence of three di-mu-oxobridged units in the Mn4Ca cluster. This result imposes clear limitations on the proposed structures based on spectroscopic and diffraction data and provides input for refining such structures.

We report on searches for B{sup -} {yields} D{sub S}{sup -}{phi} and B{sup -} {yields} D*{sub S}{sup -}{phi}. In the context of the Standard Model the branching fractions for these decays are expected to be highly suppressed, since they proceed through annihilation of the b and {bar u} quarks in the B{sup -} meson. Our results are based on 234 million {Upsilon}(42) {yields} B{bar B} decays collected with the BABAR detector at SLAC. We find no evidence for these decays, and we set 90% confidence level upper limits on the branching fractions {Beta}(B{sup -} {yields} D{sub S}{sup -}{phi}) < 1.8 x 10{sup -6}; {Beta}(B{sup -} {yields} D*{sub S}{sup -}{phi}) < 1.1 x 10{sup -5}. These results are consistent with Standard Model expectations.

With a sample of 232 x 10{sup 6} {Upsilon}(4S) {yields} B{bar B} events collected with the BABAR detector, we study the decay B{sup +} {yields} p{bar p}K{sup +} excluding charmonium decays to p{bar p}. We measure a branching fraction {Beta}(B{sup +} {yields} p{bar p}K{sup +}) = (6.7 {+-} 0.5 {+-} 0.4) x 10{sup -6}. An enhancement at low p{bar p} mass is observed and the Dalitz plot asymmetry suggests dominance of the penguin amplitude in this B decay. We search for a pentaquark candidate {Theta}*{sup ++} decaying into pK{sup +} in the mass range 1.43 to 2.00 GeV/c{sup 2} and set limits on {Beta}(B{sup +} {yields} {Theta}*{sup ++} {bar p}) x {Beta}({Theta}*{sup ++} {yields} pK{sup +}) at the 10{sup -7} level.

Using a sample of 232 million {Upsilon}(4S) {yields} B{bar B} events collected with the BABAR detector at the PEP-II B Factory in 1999-2004, they study B{sup -} {yields} K{sup 0}K*(892){sup -} decays where K*{sup -} {yields} K{sub S}{sup 0} {pi}{sup -} and D{sup 0} {yields} K{sup -}{pi}{sup +}, K{sup -}{pi}{sup +}{pi}{sup 0}, K{sup -}{pi}{sup +}{pi}{sup +}{pi}{sup -} (non-CP final states); K{sup +}K{sup -}, {pi}{sup +}{pi}{sup -} (CP+ eigenstates); K{sub S}{sup 0}{pi}{sup 0}, K{sub S}{sup 0}{phi} and K{sub S}{sup 0}{omega} (CP- eigenstates). They measure four observables that are sensitive to the angle {gamma} of the CKM unitarity triangle; the partial-rate charge asymmetries A{sub CP{+-}} and the ratios of the B-decay branching fraction in CP{+-} and non-CP decays R{sub CP{+-}}: A{sub CP+} = -0.08 {+-} 0.19 (stat.) {+-} 0.08 (syst.); A{sub CP-} = -0.26 {+-} 0.40 (stat.) {+-} 0.12 (syst.); R{sub CP+} = 1.96 {+-} 0.40 (stat.) {+-} 0.11 (syst.); R{sub CP-} = 0.65 {+-} 0.26 (stat.) {+-} 0.08 (syst.).

For over ten years, the Counterproliferation Analysis and Planning System (CAPS) at Lawrence Livermore National Laboratory (LLNL) has been a planning tool used by U.S. combatant commands for mission support planning against foreign programs engaged in the manufacture of weapons of mass destruction (WMD). CAPS is endorsed by the Secretary of Defense as the preferred counterproliferation tool to be used by the nation's armed services. A sister system, the Homeland-Defense Operational Planning System (HOPS), is a new operational planning tool leveraging CAPS expertise designed to support the defense of the U.S. homeland. HOPS provides planners with a basis to make decisions to protect against acts of terrorism, focusing on the defense of facilities critical to U.S. infrastructure. Criticality of facilities, structures, and systems is evaluated on a composite matrix of specific projected casualty, economic, and sociopolitical impact bins. Based on these criteria, significant unidentified vulnerabilities are identified and secured. To provide insight into potential successes by malevolent actors, HOPS analysts strive to base their efforts mainly on unclassified open-source data. However, more cooperation is needed between HOPS analysts and facility representatives to provide an advantage to those whose task is to defend these facilities. Evaluated facilities include: refineries, major ports, …

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The Linac Coherent Light Source (LCLS) is a Self-Amplified Spontaneous Emission based Free Electron Laser (FEL) that is being designed and built at the Stanford Linear Accelerator Center (SLAC) by a multilaboratory collaboration. This facility will provide ultra-short pulses of coherent x-ray radiation with the fundamental harmonic energy tunable over the energy range of 0.82 to 8.2 keV. One-third of the existing SLAC LINAC will compress and accelerate the electron beam to energies ranging from 4.5 GeV to 14.35 GeV. The beam will then be transported through a 130-meter long undulator, emit FEL and spontaneous radiation. After passing through the undulator, the electron beam is bent to the main electron dump. The LCLS will have two experiment halls as well as x-ray optics and infrastructure necessary to make use of the FEL for research and development in a variety of scientific fields. The facility design will incorporate features that would make it possible to expand in future such that up to 6 independent undulators can be used. While some of the radiation protection issues for the LCLS are similar to those encountered at both high-energy electron linacs and synchrotron radiation facilities, LCLS poses new challenges as well. Some of these …