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8-oxoguainine enhances bending of DNA that favors binding of glycosylases
Molecular dynamics (MD) simulations were carried out on the DNA oligonucleotide GGGAACAACTAG:CTAGTTGTTCCC in its native form and with guanine in the central G19:C6 base pair replaced by 8-oxoguanine (8oxoG). A box of explicit water molecules was used for solvation and Na+ counterions were added to neutralize the system. The direction and magnitude of global bending were assessed by a technique used previously to analyze simulations of DNA containing a thymine dimer. The presence of 8oxoG did not greatly affect the magnitude of DNA bending; however, bending into the major groove was significantly more probable when 8oxoG replaced G19. Crystal structures of glycosylases bound to damaged-DNA substrates consistently show a sharp bend into the major groove at the damage site. We conclude that changes in bending dynamics that assist the formation of this kink are a part of the mechanism by which glycosylases of the base excision repair pathway recognize the presence of 8oxoG in DNA.
Date:
April 23, 2003
Creator:
Miller, John H.
Object Type:
Article
System:
The UNT Digital Library
An 8-Step Program: Shaping and Fixed-Time Food Delivery Effects on Several Approximations and Undesired Responses in Goats.
This study investigated the effects of a shaping program for halter training across 8 steps in the program and 4 trial-terminating, or "undesirable," responses. Three La Mancha goats (Capra hircus) located at the Frank Buck Zoo in Gainesville, Texas were used for the study. A fixed-time 15 s (FT-15 s) was used during the baseline conditions, to examine the effects of response contingent and response-independent food deliveries, as well as to examine what preliminary steps might not necessarily have to be shaped. All 3 goats successfully learned to allow the halter to be placed on them and to lead on the halter, although 2 of the 3 goats required an additional task analysis for the fifth step to further break down that approximation. Several of the early steps selected by the researchers were not necessary to complete the program, as determined by the baseline condition.
Date:
May 2003
Creator:
Fernandez, Eduardo J.
Object Type:
Thesis or Dissertation
System:
The UNT Digital Library
$9.5 Million in Savings Identified Through Inland Assessment: Plant-Wide Assessment Summary--Forest Products (Fact Sheet)
Summary of Inland Box Corporation's plant-wide assessment to identify energy and cost saving opportunities at the corporation's linerboard mill in Rome, Georgia.
Date:
August 1, 2003
Creator:
unknown
Object Type:
Text
System:
The UNT Digital Library
9-11 Commission Hearing #1, April 1, 2003, Part 1
Recording of the first public hearing held by the National Commission on Terrorist Attacks upon the United States on April 1, 2003 at the Alexander Hamilton U.S. Custom House. This hearing specifically addresses the topics of borders, money, and transportation; law enforcement, domestic intelligence, and homeland security; and immediate response to the attacks. This section includes testimony on the topic of borders, money, and transportation security from representatives of the U.S. Department of Justice, Boies, Schiller, & Flexner LLP, and the U.S. General Accounting Office. It also includes a question and answer session.
Date:
April 1, 2003
Creator:
National Commission on Terrorist Attacks upon the United States
Object Type:
Video
System:
The UNT Digital Library
9-11 Commission Hearing #1, April 1, 2003, Part 3
Recording of the first public hearing held by the National Commission on Terrorist Attacks upon the United States on April 1, 2003 at the Alexander Hamilton U.S. Custom House in New York City.This hearing specifically addresses the topics of borders, money, and transportation; law enforcement, domestic intelligence, and homeland security; and immediate response to the attacks. This section includes testimony from representatives of RAND, the Markle Foundation, and the ANSER Institute on the topic of law enforcement, domestic intelligence, and homeland security, in addition to a question and answer session.
Date:
April 1, 2003
Creator:
National Commission on Terrorist Attacks upon the United States
Object Type:
Video
System:
The UNT Digital Library
9-11 Commission Hearing #1, April 1, 2003, Part 4
Recording of the first public hearing held by the National Commission on Terrorist Attacks upon the United States on April 1, 2003 at the Alexander Hamilton U.S. Custom House in New York City.This hearing specifically addresses the topics of borders, money, and transportation; law enforcement, domestic intelligence, and homeland security; and immediate response to the attacks. This section includes the question and answer session on law enforcement, domestic intelligence, and homeland security.
Date:
April 1, 2003
Creator:
National Commission on Terrorist Attacks upon the United States
Object Type:
Video
System:
The UNT Digital Library
9-11 Commission Hearing #1, April 1, 2003, Part 5
Recording of the first public hearing held by the National Commission on Terrorist Attacks upon the United States on April 1, 2003 at the Alexander Hamilton U.S. Custom House in New York City.This hearing specifically addresses the topics of borders, money, and transportation; law enforcement, domestic intelligence, and homeland security; and immediate response to the attacks.This section begins the testimony from representatives of the Arlington County Fire Department, the American Society of Civil Engineers, and the New York Department of Design and Construction on the topic of immediate response to the 9/11 attacks.
Date:
April 1, 2003
Creator:
National Commission on Terrorist Attacks upon the United States
Object Type:
Video
System:
The UNT Digital Library
9-11 Commission Hearing #1, April 1, 2003, Part 6
Recording of the first public hearing held by the National Commission on Terrorist Attacks upon the United States on April 1, 2003 at the Alexander Hamilton U.S. Custom House in New York City.This hearing specifically addresses the topics of borders, money, and transportation; law enforcement, domestic intelligence, and homeland security; and immediate response to the attacks.This section continues the question and answer session on the topic of the immediate response to the attacks.
Date:
April 1, 2003
Creator:
National Commission on Terrorist Attacks upon the United States
Object Type:
Video
System:
The UNT Digital Library
9-11 Commission Hearing #1, March 31, 2003, Part 1
Recording of the first public hearing held by the National Commission on Terrorist Attacks upon the United States on March 31, 2003 at the Alexander Hamilton U.S. Custom House in New York City. This purpose of this hearing was to engage those whose lives were changed by the events of September 11 in a public dialogue about the Commission's goals. This section includes the Commissioner's opening statements and remarks by George Pataki, Governor of New York and Micheal Bloomberg, the Mayor of New York City.
Date:
March 31, 2003
Creator:
National Commission on Terrorist Attacks upon the United States
Object Type:
Video
System:
The UNT Digital Library
9-11 Commission Hearing #1, March 31, 2003, Part 2
Recording of the first public hearing held by the National Commission on Terrorist Attacks upon the United States on March 31, 2003 at the Alexander Hamilton U.S. Custom House in New York City. The purpose of this hearing was to engage those whose lives were changed by the events of September 11 in a public dialogue about the Commission's goals. This section includes remarks from Micheal Bloomberg, Mayor of New York, Raymond Kelley, New York Police Commissioner, and Harry Waizer, a survivor from the financial services firm, Cantor Fitzgerald, which as headquartered in the World Trade Center.
Date:
March 31, 2003
Creator:
National Commission on Terrorist Attacks upon the United States
Object Type:
Video
System:
The UNT Digital Library
9-11 Commission Hearing #1, March 31, 2003, Part 3
Recording of the first public hearing held by the National Commission on Terrorist Attacks upon the United States on March 31, 2003 at the Alexander Hamilton U.S. Custom House in New York City. The purpose of this hearing was to engage those whose lives were changed by the events of September 11 in a public dialogue about the Commission's goals. This section concludes the opening remarks and begins the testimony from survivors of the September 11th attacks on their experiences.
Date:
March 31, 2003
Creator:
National Commission on Terrorist Attacks upon the United States
Object Type:
Video
System:
The UNT Digital Library
9-11 Commission Hearing #1, March 31, 2003, Part 4
Recording of the first public hearing held by the National Commission on Terrorist Attacks upon the United States on March 31, 2003 at the Alexander Hamilton U.S. Custom House in New York City. The purpose of this hearing was to engage those whose lives were changed by the events of September 11 in a public dialogue about the Commission's goals. This section concludes the testimony from survivors of the September 11th attacks and begins the testimony from representatives of the victims.
Date:
March 31, 2003
Creator:
National Commission on Terrorist Attacks upon the United States
Object Type:
Video
System:
The UNT Digital Library
9-11 Commission Hearing #1, March 31, 2003, Part 5
Recording of the first public hearing held by the National Commission on Terrorist Attacks upon the United States on March 31, 2003 at the Alexander Hamilton U.S. Custom House in New York City. The purpose of this hearing was to engage those whose lives were changed by the events of September 11 in a public dialogue about the Commission's goals. This section concludes the testimony from representatives of the victims and begins the testimony from professionals in various fields on the September 11th attackers, intelligence, and counter-terrorism policy.
Date:
March 31, 2003
Creator:
National Commission on Terrorist Attacks upon the United States
Object Type:
Video
System:
The UNT Digital Library
9-11 Commission Hearing #1, March 31, 2003, Part 6
Recording of the first public hearing held by the National Commission on Terrorist Attacks upon the United States on March 31, 2003 at the U.S. Alexander Hamilton Custom House. The purpose of this hearing was to engage those whose lives were changed by the events of September 11 in a public dialogue about the Commission's goals. This section continues the section on testimony from the professionals on the attackers, intelligence, and counter-terrorism policy.
Date:
March 31, 2003
Creator:
National Commission on Terrorist Attacks upon the United States
Object Type:
Video
System:
The UNT Digital Library
9-11 Commission Hearing #1, March 31, 2003, Part 7
Recording of the first public hearing held by the National Commission on Terrorist Attacks upon the United States on March 31, 2003 at the Alexander Hamilton U.S. Custom House in New York City.The purpose of this hearing was to engage those whose lives were changed by the events of September 11 in a public dialogue about the Commission's goals. This section concludes the testimony on the 9/11 attackers, intelligence, and counter-terrorism policy.
Date:
March 31, 2003
Creator:
National Commission on Terrorist Attacks upon the United States
Object Type:
Video
System:
The UNT Digital Library
9-11 Commission Hearing #2, May 22, 2003, Part 1
Recording of the second public hearing held by the National Commission on Terrorist Attacks Upon the United States on May 22, 2003 at the Hart Senate Office Building in Washington, D.C. This hearing addresses four topics, which include the commission mandate and objectives, intelligence oversight and the joint inquiry, affected constituencies, and the state of civil aviation security on September 11th. This section includes the first panel on the commission mandate and objectives, with testimony from Congresswoman Nancy Pelosi, Senator John McCain, and Senator Joseph Lieberman.
Date:
May 22, 2003
Creator:
National Commission on Terrorist Attacks upon the United States
Object Type:
Video
System:
The UNT Digital Library
9-11 Commission Hearing #2, May 22, 2003, Part 2
Recording of the second public hearing held by the National Commission on Terrorist Attacks upon the United States on May 22, 2003 at the Hart Office Senate Building in Washington, D.C. This hearing addresses four topics, which include the commission mandate and objectives, intelligence oversight and the joint inquiry, affected constituencies, and the state of civil aviation security on September 11th. This section includes the second panel on intelligence oversight and the joint inquiry with testimony from Senators Bob Graham and Richard Shelby and Representatives Porter Goss and Jane Harman.
Date:
May 22, 2003
Creator:
National Commission on Terrorist Attacks upon the United States
Object Type:
Video
System:
The UNT Digital Library
9-11 Commission Hearing #2, May 22, 2003, Part 3
Recording of the second public hearing held by the National Commission on Terrorist Attacks upon the United States on May 22, 2003 at the Hart Senate Office Building in Washington, D.C. This hearing addresses four topics, which include the commission mandate and objectives, intelligence oversight and the joint inquiry, affected constituencies, and the state of civil aviation security on September 11th. This section contains the third panel on affected constituencies with testimony from Senators Schumer, Clinton, Corzine and Lautenberg, and Representatives Nadler, Shays, and Smith.
Date:
May 22, 2003
Creator:
National Commission on Terrorist Attacks upon the United States
Object Type:
Video
System:
The UNT Digital Library
9-11 Commission Hearing #2, May 22, 2003, Part # 4
Recording of the second public hearing held by the National Commission on Terrorist Attacks upon the United States on May 22, 2003 at the Hart Senate Office Building in Washington, D.C. This hearing addresses four topics, which include the commission mandate and objectives, intelligence oversight and the joint inquiry, affected constituencies, and the state of civil aviation security on September 11th. This section includes the panel on civil aviation security with testimony from representatives of the Federal Aviation Administration, the Department of Transportation, the Air Transport Association of America, and the Transportation Security Agency.
Date:
May 22, 2003
Creator:
National Commission on Terrorist Attacks upon the United States
Object Type:
Video
System:
The UNT Digital Library
9-11 Commission Hearing #2, May 23, 2003, Part 1
Recording of the second public hearing held by the National Commission on Terrorist Attacks upon the United States on May 23 in Washington, D.C. This hearing addresses four topics, which include the commission mandate and objectives, intelligence oversight and the joint inquiry, affected constituencies, and the state of civil aviation security on September 11th. This section includes the panel on civil aviation security, with testimony from Norman Mineta, Major General Craig McKinley, and Lieutenant General Mike Canavan on the attacks and the response to the 9/11 attacks.
Date:
May 23, 2003
Creator:
National Commission on Terrorist Attacks upon the United States
Object Type:
Video
System:
The UNT Digital Library
9-11 Commission Hearing #2, May 23, 2003, Part 2
Recording of the second public hearing held by the National Commission on Terrorist Attacks upon the United States on May 23, 2003 in Washington, D.C. This hearing addresses four topics, which include the commission mandate and objectives, intelligence oversight and the joint inquiry, affected constituencies, and the state of civil aviation security on September 11th. This section concludes the panel on civil aviation security, with testimony from Stephen McHale, Major General O.K. Steele, and Mary Schiavo on reforming civil aviation security.
Date:
May 23, 2003
Creator:
National Commission on Terrorist Attacks upon the United States
Object Type:
Video
System:
The UNT Digital Library
9-11 Commission Hearing #3, July 9, 2003, Part 1
Recording of the third public hearing held by the National Commission on Terrorist Attacks upon the United States on July 9, 2003 at the Russell Senate Office Building in Washington, D.C. The one-day session focused on "Terrorism, al Qaeda, and the Muslim World." This section includes the first panel on Al Qaeda, with testimony from Rohan Gunaratna and Mamoun Fandy.
Date:
July 9, 2003
Creator:
National Commission on Terrorist Attacks upon the United States
Object Type:
Video
System:
The UNT Digital Library
9-11 Commission Hearing #3, July 9, 2003, Part 2
Recording of the third public hearing held by the National Commission on Terrorist Attacks upon the United States on July 9, 2003 at the Russell Senate Office Building in Washington, D.C. The one-day session focused on "Terrorism, al Qaeda, and the Muslim World." This section includes the second panel on States and Terrorism, and the third panel on The Challenge within the Muslim World with testimony from experts on transnational terrorism.
Date:
April 1, 2003
Creator:
National Commission on Terrorist Attacks upon the United States
Object Type:
Video
System:
The UNT Digital Library
9-11 Commission Hearing #3, July 9, 2003, Part 3
Recording of the third public hearing held by the National Commission on Terrorist Attacks upon the United States on July 9, 2003 at the Russel Senate Office Building in Washington, D.C. The one-day session focused on "Terrorism, al Qaeda, and the Muslim World." This section includes a post-hearing media advisory with Chair Thomas H. Kean and Vice Chair Lee H. Hamilton.
Date:
July 9, 2003
Creator:
National Commission on Terrorist Attacks upon the United States
Object Type:
Video
System:
The UNT Digital Library