Complex networks appear in biology on many different levels: (1) All biochemical reactions taking place in a single cell constitute its metabolic network, where nodes are individual metabolites, and edges are metabolic reactions converting them to each other. (2) Virtually every one of these reactions is catalyzed by an enzyme and the specificity of this catalytic function is ensured by the key and lock principle of its physical interaction with the substrate. Often the functional enzyme is formed by several mutually interacting proteins. Thus the structure of the metabolic network is shaped by the network of physical interactions of cell's proteins with their substrates and each other. (3) The abundance and the level of activity of each of the proteins in the physical interaction network in turn is controlled by the regulatory network of the cell. Such regulatory network includes all of the multiple mechanisms in which proteins in the cell control each other including transcriptional and translational regulation, regulation of mRNA editing and its transport out of the nucleus, specific targeting of individual proteins for degradation, modification of their activity e.g. by phosphorylation/dephosphorylation or allosteric regulation, etc. To get some idea about the complexity and interconnectedness of protein-protein regulations …

NREL will produce this sourcebook for DOE's Industrial Technologies Office as part of a series of documents on industrial energy equipment. The sourcebook is a reference for industrial compressed air system users, outlining opportunities to improve system efficiency.

Interview with W. W. Hughes, a Texas National Guard WWII veteran from Grand Prarie, Texas. Hughes discusses growing up in the Great Depression, joining the National Guard and equestrian service in the 112th Cavalry at Fort Clark, the start of war and deployment to New Caledonia and Australia, preparations for combat, amphibious landings at Arawe Island off New Britain, scout patrols and combat, operations in New Guinea at the Driniumor River, Japanese POWs, actions in the Philippines at Leyte and Luzon, returning to the US as an instructor, and reflections on his service.

Interview with Charles Kingsley, a Texas National Guard WWII veteran from Dallas, Texas, who served in the 112th Cavalry. Kingsley discusses his upbringing, joining the Guard, the Louisiana Maneuvers, deployment to New Caledonia, his troop's machine gun section/platoon, Woodlark Island, the Battle of Arawe, New Guinea and the Battle of Drinumor River, the Battles of Leyte and Luzon, his thoughts on the generals he served, and thoughts on the 112th.

Interview with landscape architect and Army veteran William Garbo Sr. The interview includes Garbo's personal experiences about the G Troop, 112th Cavalry, in the Southwest Pacific Theater during World-War II, growing up in an Italian-American family in Mississippi during the Great Depression, volunteering for the draft and processing at Camp Shelby, Hattiesburg, Mississippi, basic training at Camp Lee, Petersburg, Virginia, being assigned to the 26th War Dog Platoon and to New Guinea in 1944, the Battle of the Driniumor River and his attachment to elements of the 32nd Infantry Division, jungle patrols on New Guinea with his dog, his transfer to Troop, 112th Cavalry and the invasion of Layte, Philippines, and the living condition in the Philippine jungles. Additionally, Garbo speaks about the fighting prowess of his comrades in the 112th Cavalry, jungle patrols on Leyte and Luzon, the 112th's activities around Marungko and Antipolo, Luzon, descriptions of cannibalism by Japanese soldiers, his wounds from artillery shrapnel and evacuation by helicopter, his return to the 112th Cavalry and preparations for the invasion of Japan, witnessing the Japanese surrender in Tokyo Bay, occupation duty at Tateyama, Honshu, relations between Japanese civilians and American occupation troops, the destruction of Japanese defensive fortifications …

Interview with businessman Harold Corey. The interview includes Corey's personal experiences about the Texas International Pop Festival. Corey talks about his parents' reaction to the social, political, and cultural changes of the Sixties, his early interest in popular music, protests against the Vietnam War, conflicts with the redneck culture, the influence of the Beatles on the music of the Sixties, the influence of the "British Invasion," meeting the Grand Funk Railroad at the festival, Hog Farm, Janis Joplin, Led Zeppelin, the sale and use of drugs, the trip tent, festival security, activities at the campgrounds, comments about Ten Years After, and the lasting effects of the festival on his life. The interview includes an appendix with a campground map and festival advertisement.

Bio-molecular networks lack the top-down design. Instead, selective forces of biological evolution shape them from raw material provided by random events such as gene duplications and single gene mutations. As a result individual connections in these networks are characterized by a large degree of randomness. One may wonder which connectivity patterns are indeed random, while which arose due to the network growth, evolution, and/or its fundamental design principles and limitations? Here we introduce a general method allowing one to construct a random null-model version of a given network while preserving the desired set of its low-level topological features, such as, e.g., the number of neighbors of individual nodes, the average level of modularity, preferential connections between particular groups of nodes, etc. Such a null-model network can then be used to detect and quantify the non-random topological patterns present in large networks. In particular, we measured correlations between degrees of interacting nodes in protein interaction and regulatory networks in yeast. It was found that in both these networks, links between highly connected proteins are systematically suppressed. This effect decreases the likelihood of cross-talk between different functional modules of the cell, and increases the overall robustness of a network by localizing effects …

With the advent of massively parallel computer systems, scientists are now able to simulate complex phenomena (e.g., explosions of a stars). Such scientific simulations typically generate large-scale data sets over the spatio-temporal space. Unfortunately, the sheer sizes of the generated data sets make efficient exploration of them impossible. Constructing queriable statistical models is an essential step in helping scientists glean new insight from their computer simulations. We define queriable statistical models to be descriptive statistics that (1) summarize and describe the data within a user-defined modeling error, and (2) are able to answer complex range-based queries over the spatiotemporal dimensions. In this chapter, we describe systems that build queriable statistical models for large-scale scientific simulation data sets. In particular, we present our Ad-hoc Queries for Simulation (AQSim) infrastructure, which reduces the data storage requirements and query access times by (1) creating and storing queriable statistical models of the data at multiple resolutions, and (2) evaluating queries on these models of the data instead of the entire data set. Within AQSim, we focus on three simple but effective statistical modeling techniques. AQSim's first modeling technique (called univariate mean modeler) computes the ''true'' (unbiased) mean of systematic partitions of the data. AQSim's …

This document provides an instructional lesson plan for parents that consist of mixing cereal, introducing solid foods, and targeting healthy habits for their newborn infants.

Biweekly, comprehensive compilation of decisions, reports, public notices, and other documents of the U.S. Federal Communications Commission.

Biweekly, comprehensive compilation of decisions, reports, public notices, and other documents of the U.S. Federal Communications Commission.