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Disruption of NBS1 gene leads to early embryonic lethality in homozygous null mice and induces specific cancer in heterozygous mice
Nijmegen breakage syndrome (NBS) is a rare autosomal recessive chromosome instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition, with cellular features similar to that of ataxia telangiectasia (AT). NBS results from mutations in the mammalian gene Nbs1 that codes for a 95-kDa protein called nibrin, NBS1, or p95. To establish an animal model for NBS, we attempted to generate NBS1 knockout mice. However, NBS1 gene knockouts were lethal at an early embryonic stage. NBS1 homozygous(-/-) blastocyst cells cultured in vitro showed retarded growth and subsequently underwent growth arrest within 5 days of culture. Apoptosis, assayed by TUNEL staining, was observed in NBSI homozygous(-/-) blastocyst cells cultured for four days. NBSI heterozygous(+/-) mice were normal, and exhibited no specific phenotype for at least one year. However, fibroblast cells from NBSI heterozygous(+/-) mice displayed an enhanced frequency of spontaneous transformation to anchorage-independent growth as compared to NBS1 wild-type(+/+) cells. Furthermore, heterozygous(+/-) mice exhibited a high incidence of hepatocellular carcinoma after one year compared to wild-type mice, even though no significant differences in the incidence of other tumors such as lung adenocarcinoma and lymphoma were observed. Taken together, these results strongly suggest that NBS1 heterozygosity and reduced NBSI expression induces …
Date:
April 15, 2002
Creator:
Kurimasa, Akihiro; Burma, Sandeep; Henrie, Melinda; Ouyang, Honghai; Osaki, Mitsuhiko; Ito, Hisao et al.
Object Type:
Report
System:
The UNT Digital Library
Development of a Versatile Laser Ultrasonic System and Application to On-Line Measurement for Process Control of Wall Thickness and Eccentrictiy of Steel Seamless Mechanical Tubing
Researchers at the Timken Company conceived a project to develop an on-line instrument for wall thickness measurement of steel seamless mechanical tubing based on laser ultrasonic technology. The instrument, which has been installed and tested at a piercing mill, provides data on tube eccentricity and concentricity. Such measurements permit fine-tuning of manufacturing processes to eliminate excess material in the tube wall and therefore provide a more precisely dimensioned product for their customers. The resulting process energy savings are substantial, as is lowered environmental burden. The expected savings are $85.8 million per year in seamless mechanical tube piercing alone. Applied across the industry, this measurement has a potential of reducing energy consumption by 6 x 10{sup 12} BTU per year, greenhouse gas emissions by 0.3 million metric tons carbon equivalent per year, and toxic waste by 0.255 million pounds per year. The principal technical contributors to the project were the Timken Company, Industrial Materials Institute (IMI, a contractor to Timken), and Oak Ridge National Laboratory (ORNL). Timken provided mill access as well as process and metallurgical understanding. Timken researchers had previously developed fundamental ultrasonic analysis methods on which this project is based. IMI developed and fabricated the laser ultrasonic generation and …
Date:
April 24, 2002
Creator:
Kisner, R. A.; Kercel, S. W.; Damiano, B.; Bingham, P. R.; Gee, T. F.; Tucker, R. W. et al.
Object Type:
Report
System:
The UNT Digital Library
An Audit Report on Licensing and Enforcement at the Alcoholic Beverage Commission
Report of the Texas State Auditor's Office related to licenses and permits processed, issued, or renewed by the Alcoholic Beverage Commission.
Date:
April 2002
Creator:
Texas. Office of the State Auditor.
Object Type:
Report
System:
The Portal to Texas History
A Report on the Fiscal Year 2002 University Accreditation Reviews
Report of the Texas State Auditor's Office related to six accreditation review reports published in fiscal year 2002, required as a part of the Southern Association of Colleges and Schools (SACS) university accreditation process.
Date:
April 2002
Creator:
Texas. Office of the State Auditor.
Object Type:
Report
System:
The Portal to Texas History
An Audit Report on the Medical Transportation Program at the Department of Health
Report of the Texas State Auditor's Office related to determining if the procedures the Department of Health uses to establish and monitor client service contracts provide reasonable assurance that contractors provide agreed-upon services at contractually specified prices, and that contractors spend funds in accordance with state and federal requirements.
Date:
April 2002
Creator:
Texas. Office of the State Auditor.
Object Type:
Report
System:
The Portal to Texas History
An Audit Report on State-Issued Bonds for Fiscal Year 2001
Report of the Texas State Auditor's Office related to determining whether state bond-issuing entities were in compliance with requirements in significant bond covenants and applicable laws and regulations, and verifying the accuracy of information reported in the bond schedules in each entity's annual financial report.
Date:
April 2002
Creator:
Texas. Office of the State Auditor.
Object Type:
Report
System:
The Portal to Texas History
A Financial Review of the Department of Mental Health and Mental Retardation
Report of the Texas State Auditor's Office related to determining whether the Department of Mental Health and Mental Retardation's (Department) reporting processes enable it to provide legislative budget committees and board members with accurate and consistent financial information; determining whether the Department is using appropriated funds in accordance with applicable laws and regulations; and determining the relationship between funds expended and outcome results.
Date:
April 2002
Creator:
Texas. Office of the State Auditor.
Object Type:
Report
System:
The Portal to Texas History
A Report on Certification of the Permanent School Fund's Bond Guarantee Program
Report of the Texas State Auditor's Office related to determining whether the total amount of school district bonds guaranteed by the Bond Guarantee Program (Program) exceeded the limits established by state statute and the Internal Revenue Service.
Date:
April 2002
Creator:
Texas. Office of the State Auditor.
Object Type:
Report
System:
The Portal to Texas History
University Press (Beaumont, Tex.), Vol. 78, No. 42, Ed. 1 Wednesday, April 17, 2002
Semiweekly newspaper from Lamar University in Beaumont, Texas that includes local, national, and campus news along with advertising.
Date:
April 17, 2002
Creator:
Chand, Daniel
Object Type:
Newspaper
System:
The Portal to Texas History
University Press (Beaumont, Tex.), Vol. 78, No. 40, Ed. 1 Wednesday, April 10, 2002
Semiweekly newspaper from Lamar University in Beaumont, Texas that includes local, national, and campus news along with advertising.
Date:
April 10, 2002
Creator:
Chand, Daniel
Object Type:
Newspaper
System:
The Portal to Texas History
University Press (Beaumont, Tex.), Vol. 78, No. 41, Ed. 1 Friday, April 12, 2002
Semiweekly newspaper from Lamar University in Beaumont, Texas that includes local, national, and campus news along with advertising.
Date:
April 12, 2002
Creator:
Chand, Daniel
Object Type:
Newspaper
System:
The Portal to Texas History
Bogata News (Bogata, Tex.), Vol. 91, No. 45, Ed. 1 Thursday, April 4, 2002
Weekly newspaper from Bogata, Texas that includes local, state, and national news along with advertising.
Date:
April 4, 2002
Creator:
Nichols, Nanalee & Nichols, Thomas
Object Type:
Newspaper
System:
The Portal to Texas History
Mannford Eagle (Mannford, Okla.), Vol. 20, No. 50, Ed. 1 Wednesday, April 10, 2002
Weekly newspaper from Mannford, Oklahoma that includes local, state, and national news along with advertising.
Date:
April 10, 2002
Creator:
Retherford, Bill R.
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Mannford Eagle (Mannford, Okla.), Vol. 20, No. 52, Ed. 1 Wednesday, April 24, 2002
Weekly newspaper from Mannford, Oklahoma that includes local, state, and national news along with advertising.
Date:
April 24, 2002
Creator:
Retherford, Bill R.
Object Type:
Newspaper
System:
The Gateway to Oklahoma History
Cherokeean/Herald (Rusk, Tex.), Vol. 153, No. 6, Ed. 1 Wednesday, April 3, 2002
Weekly newspaper from Rusk, Texas that includes local, state and national news along with extensive advertising.
Date:
April 3, 2002
Creator:
Whitehead, Marie
Object Type:
Newspaper
System:
The Portal to Texas History
Cherokeean/Herald (Rusk, Tex.), Vol. 153, No. 7, Ed. 1 Wednesday, April 10, 2002
Weekly newspaper from Rusk, Texas that includes local, state and national news along with extensive advertising.
Date:
April 10, 2002
Creator:
Whitehead, Marie
Object Type:
Newspaper
System:
The Portal to Texas History
Cherokeean/Herald (Rusk, Tex.), Vol. 153, No. 8, Ed. 1 Wednesday, April 17, 2002
Weekly newspaper from Rusk, Texas that includes local, state and national news along with extensive advertising.
Date:
April 17, 2002
Creator:
Whitehead, Marie
Object Type:
Newspaper
System:
The Portal to Texas History
Cherokeean/Herald (Rusk, Tex.), Vol. 153, No. 9, Ed. 1 Wednesday, April 24, 2002
Weekly newspaper from Rusk, Texas that includes local, state and national news along with extensive advertising.
Date:
April 24, 2002
Creator:
Whitehead, Marie
Object Type:
Newspaper
System:
The Portal to Texas History
The University News (Irving, Tex.), Vol. 104, No. 2, Ed. 1 Monday, April 1, 2002
Weekly student newspaper from the University of Dallas in Irving, Texas that includes campus news and commentaries along with advertising.
Date:
April 1, 2002
Creator:
Watson, Thomas & Danaher, Julie
Object Type:
Newspaper
System:
The Portal to Texas History
The University News (Irving, Tex.), Vol. 31, No. 21, Ed. 1 Wednesday, April 10, 2002
Weekly student newspaper from the University of Dallas in Irving, Texas that includes campus news and commentaries along with advertising.
Date:
April 10, 2002
Creator:
Watson, Thomas & Danaher, Julie
Object Type:
Newspaper
System:
The Portal to Texas History
The University News (Irving, Tex.), Vol. 31, No. 22, Ed. 1 Wednesday, April 17, 2002
Weekly student newspaper from the University of Dallas in Irving, Texas that includes campus news and commentaries along with advertising.
Date:
April 17, 2002
Creator:
Watson, Thomas & Danaher, Julie
Object Type:
Newspaper
System:
The Portal to Texas History
The Rambler (Fort Worth, Tex.), Vol. 87, No. 8, Ed. 1 Monday, April 1, 2002
Weekly student newspaper from Texas Wesleyan University in Fort Worth, Texas that includes campus and local news along with advertising.
Date:
April 1, 2002
Creator:
Manning, Melanie
Object Type:
Newspaper
System:
The Portal to Texas History
The Rambler (Fort Worth, Tex.), Vol. 87, No. 9, Ed. 1 Thursday, April 4, 2002
Weekly student newspaper from Texas Wesleyan University in Fort Worth, Texas that includes campus and local news along with advertising.
Date:
April 4, 2002
Creator:
Manning, Melanie
Object Type:
Newspaper
System:
The Portal to Texas History
The Rambler (Fort Worth, Tex.), Vol. 87, No. 10, Ed. 1 Thursday, April 11, 2002
Weekly student newspaper from Texas Wesleyan University in Fort Worth, Texas that includes campus and local news along with advertising.
Date:
April 11, 2002
Creator:
Manning, Melanie
Object Type:
Newspaper
System:
The Portal to Texas History