Interview with Thomas Dunaway Anderson starting with his recollections of his uncle, Monroe Dunaway Anderson, the founder of the M.D. Anderson foundation and namesake of the University of Texas M.D. Anderson Cancer Center. The interview continues with a description of the establishment and purpose of the M.D. Anderson Foundation and the growth and development of several recipients of M.D. Anderson’s philanthropy, including the University of Texas M.D. Anderson Cancer Center and the Texas Medical Center. Thomas Anderson’s memories and interactions regarding Dr. Randolph Lee Clark, the first full-time president of what is known today as the University of Texas M.D. Anderson Cancer Center, are recounted as well. A discussion concerning Thomas Anderson’s family contributions associated with the University of Texas M.D. Anderson Cancer Center and the Texas Medical Center ends the interview.