Preliminary designs of an intense heavy-ion beam transport experiment to test issues for Heavy Ion Fusion (HIF) are presented. This transport channel will represent a single high current density beam at full driver scale and will evaluate practical issues such as aperture filling factors, electrons, halo, imperfect vacuum, etc., that cannot be fully tested using scaled experiments. Various machine configurations are evaluated in the context of the range of physics and technology issues that can be explored in a manner relevant to a full scale driver. it is anticipated that results from this experiment will allow confident construction of next generation ''Integrated Research Experiments'' leading to a full scale driver for energy production.

The Diesel Emission Control-Sulfur Effects (DECSE) is a joint government/industry program to determine the impact of diesel fuel sulfur levels on emission control systems whose use could lower emissions of nitrogen oxides (NOx) and particulate matter (PM) from on-highway trucks in the 2002--2004 model years. Phase 1 of the program was developed with the following objectives in mind: (1) evaluate the effects of varying the level of sulfur content in the fuel on the emission reduction performance of four emission control technologies; and (2) measure and compare the effects of up to 250 hours of aging on selected devices for multiple levels of fuel sulfur content. This is the fourth and final report for the DPF test program and covers the effect of diesel sulfur level on: a catalyzed diesel particulate filter (CDPF), and a continuously regenerating diesel particulate filter (CR-DPF).

OAK - B135 The initial kickoff meeting/brainstorming session was held as Albuquerque with the other participants in this study. The prompt critical pulse reactor was proposed at the brainstorming session. The other participants in this study, Sandia National Laboratories (lead), Los Alamos National Laboratory, University of Florida and Texas A and M University are separately funded and their work is separately reported. The combined reporting is done by Sandia.

At relativistic energies, the cross section for the atomic photoelectric effect drops off as does the cross section for liberating any bound electron through Compton scattering. However, when the photon energy exceeds twice the rest mass of the electron, ionization may proceed via electron-positron pair creation. We used 1.33 MeV photons impinging on Au thin foils to study double K-shell ionization and vacuum-assisted photoionization. The preliminary results yield a ratio of vacuum-assisted photoionization and pair creation of 2x10{sup -3}, a value that is substantially higher than the ratio of photo double ionization to single photoionization that is found to be 0.5-1x10{sup -4}. Because of the difficulties and large error bars associated with the small cross sections additional measurements are needed to minimize systematic errors.

OAK B202 Treatment of cells with oxidative DNA damaging agents such as ionizing radiation and hydrogen peroxide produces .OH radicals which attack DNA, producing single strand breaks and double strand breaks that have a 3'-blocked terminus with a phosphoglycolate or a phosphate group attached to the 3'-terminus. While DNA strand breaks with 3'-blocked termini are the hallmark of oxidative DNA damage, the mechanisms by which such blocked 3'-termini are removed in eukaryotes remain poorly understood. The goals of this project were to identify the various genes that function in cleaning the blocked 3'ends from DNA strand breaks generated by treatments with ionizing radiation and hydrogen peroxide, to purify the proteins encoded by these genes and to characterize their biochemical activities, and to determine the biological consequences when such damage is not repaired. Because of the high degree of conservation of DNA repair proteins between yeast and humans, and because of the ease of genetic manipulations, initial studies were to be carried out in Saccharomyces cerevisiae. The homologous genes and proteins would then be studied in humans. One aspect of our proposed research was to purify the Apn2 protein from yeast cells and to examine its AP endonuclease and 3'-phosphodiesterase activities. …

Treatment of cells with oxidative DNA damaging agents such as ionizing radiation and hydrogen peroxide produces .OH radicals which attack DNA, producing single strand breaks and double strand breaks that have a 3'-blocked terminus with a phosphoglycolate or a phosphate group attached to the 3'-terminus. While DNA strand breaks with 3'-blocked termini are the hallmark of oxidative DNA damage, the mechanisms by which such blocked 3'-termini are removed in eukaryotes remain poorly understood. The goals of this project were to identify the various genes that function in cleaning the blocked 3'-ends from DNA strand breaks generated by treatments with ionizing radiation and hydrogen peroxide, to purify the proteins encoded by these genes and to characterize their biochemical activities, and to determine the biological consequences when such damage is not repaired. Because of the high degree of conservation of DNA repair proteins between yeast and humans, and because of the ease of genetic manipulations, initial studies were to be carried out in Saccharomyces cerevisiae. The homologous genes and proteins would then be studied in humans. One aspect of our proposed research was to purify the Apn2 protein from yeast cells and to examine its AP endonuclease and 3'-phosphodiesterase activities. Apn2-like proteins …