The relationship between psychological hardiness and individuals' coping with two life events, involuntary job loss and post-parental launching of adolescent children, was investigated in a sample of 146 adults, 83 of which had experienced job loss and 61 of which had experienced the empty nest. Volunteers completed questionnaires which measured hardiness, distress, coping strategies, neuroticism, and extraversion. Multivariate analyses were performed, both with and without covariates, for overall hardiness as well as the hardiness subscales of control, commitment, and challenge. Significant hardiness by life event interactions on escape-avoidance coping were found in both sets of analyses. Main effects for hardiness, however, disappeared when controls for neuroticism and extraversion were utilized. Findings underscore the necessity of employing neuroticism controls in future hardiness research.