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An In Vitro Study of the Effects of Methylprednisolone on Lesioned and Uninjured Mammalian Spinal Cord Neurons
The studies reported in this dissertation constitute the first evidence that methylprednisolone (MP) has been shown to ameliorate specific components of secondary trauma including ischemia, lactic acidosis, and lipid peroxidation.
Date:
December 1993
Creator:
Rosenberg-Schaffer, Lisa (Lisa Jo)
System:
The UNT Digital Library
Evidence for a Role of the Multifunctional Calcium/Calmodulin-Dependent Protein Kinase II in Insulin Secretion
Calcium/calmodulin-dependent protein kinase II (CaM kinase II) is demonstrated to exist in the ß-cell and immunopecipitation. Glucose and potassium significantly stimulate the rapid autophosphorylation of CaM kinase II and proportionally induce autonomous activity of the kinase in a dose-dependent manner that parallels insulin secretion. The activation of CaM kinase II, alloxan, KN-62 and KN-93, suggest that the enzyme is an integral component of insulin secretion and/or related processes in the β-cell.
Date:
December 1993
Creator:
Wenham, Robert M. (Robert Michael)
System:
The UNT Digital Library
Synthesis, Purification and Pharacterization of Small Mono(ADP-Ribosyl)ated Molecules in the ADP-Ribose Elongation Reaction Catalyzed by Poly(ADP-ribose)Polymerase
The ADP-ribose elongation catalyzed by poly(ADP-ribose) polymerase (PARP) [EC 2.2.2.30] has been partially characterized utilizing mono (ADP-ribosyl)ated polyamines. Arginine methyl ester (AME)-(ADP-ribose) and agmatine (AGMT)-(ADP-ribose) were synthesized enzymatically with a eukarytic mono(ADP-ribosyl) transferase and cholera toxin, respectively.
Date:
December 1993
Creator:
Pacheco-Rodriguez, Gustavo
System:
The UNT Digital Library
An Analysis of Adding Land Cover as a Variable to the DRASTIC Ground Water Model
This study involved a geographic information systems (GIS) approach to modeling ground water pollution potential in the Southern Edwards Aquifer Region in Texas. The DRASTIC ground water model was analyzed using two methods. First, the effects of adding land cover data to the drastic model were evaluated. In the second approach, the effects of the removal of DRASTIC variables were evaluated. Six, five, and four variable models were generated and analyzed.
Date:
December 1993
Creator:
Klingler, Thomas H. (Thomas Henry)
System:
The UNT Digital Library
Ultrastructure of Azotobacter Vinelandii
The purpose of this research was to reveal the morphological and cytological characteristics of Azotobacter vinelandii cells cultured in dialyzed soil medium. Culture samples taken at two, four, eight, sixteen and thirty-two days were prepared and examined with the electron microscope. Comparisons of the morphology of Azotobacter vinelandii grown in dialyzed soil medium with those grown in Burk's nitrogen-free, chemically-defined medium were done.
Date:
December 1993
Creator:
Chao, Ying L. (Ying Liang)
System:
The UNT Digital Library
Neurotransmitter receptors in the suprachiasmatic nucleus: circadian and developmental studies
The present audiographic study examined ligands for three receptors, chosen on the basis of high abundance of these receptors in the SCN relative to other brain regions([125I)VIP and [125I) angiotensin II) or the ability of pharmacological manipulations to affect the phase and period of circadian rhythms.
Date:
December 1993
Creator:
Robinson, Miqun L. (Miqun Li)
System:
The UNT Digital Library