A study was conducted to investigate factors associated with the perceived future self-efficacy in adolescents with spina bifida. Thirteen adolescents with spina bifida and their parents were surveyed. Seventeen adolescents without an identified disability and their parents were also surveyed. The Questionnaire of Future Adult Activities (QFAA) and the Health Attribution Test (HAT) were administered. Parent responses were compared to those of adolescents and adolescent responses were compared between groups. There was no overall correlation between parent and adolescent responses. Differences were found between responses of adolescents with spina bifida and adolescents without an identified disability. Limited correlations were found between the QFAA and the HAT.