Abstract: Automated time-difference measurements at the picosecond level have been achieved. The system described combines the best properties of three common methods: the single heterodyne measurement technique, the frequency divider, and the dual-mixer time-difference measurement system. This particular system combines two instrumentation standards, ANSI/IFEE-583 and ANSI/IEEE-488 with new, modular dual-mixer time-difference measurement hardware. The modular, standardized hardware together with the new measurement techniques permit the data acquisition modules to be contained in a standard CAMAC crate. This system, along with an external controller, is capable of measuring eiqht clocks, at the present time, and is expandable to twenty-four clocks with modified software and additional measurement modules. The system noise performance is described by a (rT = 3 x 10^-12 t^-1 for time difference measurements.