This study deals with the (4+2)-cycloaddition reactions of 4-π electron compounds with ketenes. Chloroketenes were generated in situ from the corresponding chlorinated acid chlorides in the presence of the ketenophiles. Chloro-, dichloro- and diphenylketenes reacted with 1-methoxy-3-trimethylsiloxy-l,3-butadiene, and 2,4-bis(trimethylsiloxy)-1,3-pentadiene to yield the corresponding dihydropyrans. The dihydropyrans yielded substituted 4-pyranones on hydrolysis.

This study had a twofold purpose. First, the usefulness of the simplex algorithm as a short method of optimization in high performance liquid chromatographic separations was investigated. The second was to test a modified simplex method. The volume fractions of mobile phase components were chosen as the variable factors in the optimization process. Four test cases were performed which included separation of cholesterol esters, naphthalene and its derivatives, polycyclic aromatic compounds, and the thiane compounds. The standard for accepting an optimum was based on the baseline separation of two adjacent peaks and the analysis time. In addition to successful separations, the correlation between the separation and the chemical characteristics of mobile phase compositions was calculated and this could then be used for further modification of simplex search strategy.

A sodium fusion-Ion chromatographic method for determination of fluorine, chlorine, bromine, and iodine in organic compounds is described. Seventeen organic halogen compounds and eleven mixtures were decomposed by Na fumes at 280-290°C for one hour or longer. The absorbing solutions were injected for ion chromatographic analysis using electrochemical and conductometric detectors. The arrangement of the apparatus includes the placement of the electrochemical and conductometric detectors. This method provides a mechanism providing for complete analysis for all four halogens in one ion chromatographic sample injection. Reproducibility is excellent and liquid sample handling is mentioned.