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Nuclear Medicine Technology Progress Report for Quarter Ending June 30, 1980
Results of experiments demonstrated that the alkyl portion of 9-telluraheptadecanoic acid (9-THDA) is retained in the myocardial tissue of rats to the same extent as radioactivity from /sup 123m/Te-9-THDA. Tissue distribution experiments in rats one hr after injection of 10-(/sup 14/C)-9-telluraheptadecanoic acid were compared with the results of a parallel study using /sup 123m/Te-9-THDA. The results indicate that the alkyl region of 9-THDA is retained in the myocardium and that labeling of this portion of the 9-THDA molecule with radiohalogens such as /sup 123/I may be an attractive approach for evaluation of myocardial function. Results of preliminary studies for the development of radiolabeled barbiturates as a new class of agents for the measurement of regional blood perfusion in the brain are also described. Several new barbiturates substituted at the C-5 position were prepared and characterized. These compounds will be labeled with /sup 117m/Sn, /sup 75/Se, and /sup 123m/Te and brain uptake studies performed in rats. Studies of arsenic trioxide (As/sub 2/O/sub 3/) toxicity for human cells in the diffusion chamber assay system have continued. Studies employing /sup 74/As/sub 2/O/sub 3/ have demonstrated that uptake of radioactivity from test substances administered to rats can be detected in cells taken from the …
Date:
January 1, 1981
Creator:
Knapp, Furn F., Jr.
System:
The UNT Digital Library