The research described herein is concerned with the synthesis of certain organic compounds which have the amino-oxy grouping and are related in structure to the naturally occurring amines, putrescine, spermidine and spermine.

The purpose of the investigation described herein was to investigate the degree of delocalization of the unpaired electron in ion radicals formed in the oxidation process of compounds with aromatic rings connected by means of various groups and atoms not entering the ring; then, to establish the relationship of coupling constants in radical cations with substituent σ values. The parent cation radical, in which the co-planar ion was derived from N,N-dimethylaniline, was selected in order to maximize the substituent effects on coupling constants and to obtain couplings at several positions (specifically, CH3, N, and ring protons).

In an effort to study the spectral, magnetic, and stereochemical properties of vanadyl complexes, both a new series of vanadyl complexes derived from type (VII) ligands with subnormal magnetic moment and from type (VIII) ligands with normal magnetic moment are synthesized and characterized.

The initial purpose of this study was to determine if steric problems would account for the difference in the products obtained in the reaction of the N-(substituted)phthalimide with low and high molecular weight amines.

This investigation involved the synthesis of 1-amino-2-hydroxycyclopentanecarboxylic acid, a potential structural analog of the natural amino acids, serine and threonine. The title compound also includes the structural features present in an established antitumor agent, cycloleucine.